DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and AgaP_AGAP004154

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_313038.5	Gene:	AgaP_AGAP004154 / 1273981	VectorBaseID:	AGAP004154	Length:	1370	Species:	Anopheles gambiae

Alignment Length:	1377	Identity:	812/1377 - (58%)
Similarity:	965/1377 - (70%)	Gaps:	141/1377 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 HKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLKEYQTT----- 137
            :::|::|.|||:||||||||||||:|||||:|.|.|.|:|.||..|.|||.|||||||.|
Mosquito    11 YRVSSSGFFELQILEISNTNSHLLSGYCCGLPPEKRQTQTTGCPACATAFSLCLKEYQGTTSSVQ 75

  Fly   138 -------------EQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQ 189
                         |...|...||:||||:|.:||||||||:||.||.|.||||||||||||||||
Mosquito    76 QQQQQLKQPAVAVEPQPSGLYGCAFGNASTPVLGGSSFVLTDPEVGGITLPFTFRWTKSFTLILQ 140

  Fly   190 ALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCR 254
            ||||||.||..:||||:|||:|||||||.:|.||||||::||||||||||||..|||||||||||
Mosquito   141 ALDMYNESYSISERLIDETSFSGVILPSHDWNTLDHIGKSARITYRVRVQCADNYYNTTCTTFCR 205

  Fly   255 PRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECM 319
            ||:||||||.||.:|.|:|:.||||.|||:||||.|||.:|||||:|||||||||||||||||||
Mosquito   206 PRNDQFGHYTCGKQGNKVCMPGWQGANCEKAICKPGCDQIHGKCDQPGECECRPGWRGPLCNECM 270

  Fly   320 VYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSG 384
            |||||:||.||||||:|:|||||||||||||||:|||||||.|||||||||||:|||||||||||
Mosquito   271 VYPGCRHGYCNGSAWQCICDTNWGGILCDQDLNYCGTHEPCMHGGTCENTAPDQYRCTCAEGLSG 335

  Fly   385 EQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQ--------VYRTSHGRSNMGRPVRRS------- 434
            .:|||||||||.:||:|||||||..::::.|.        |.|...|.|:||:|..||
Mosquito   336 TRCEIVEHPCAPQPCKNGGTCTLTGNDKSAAVASSTVASIVVRGMRGMSSMGKPFGRSAAGAGGS 400

  Fly   435 ----SSMRSLDHLRPEGQALNG--SSSPGL--VSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINI 491
                |...:||   .:.||.:|  |||.||  .|.|..|..:    ||.|.||.|||||||||||
Mosquito   401 SSAGSGSGTLD---SKDQAKSGSSSSSAGLPAPSAGGPQPMK----DFVCTCAPGWTGPTCEINI 458

  Fly   492 DECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGS 556
            ||||..||.:|||||||||.|||||||:|.||.||.||:|||                      |
Mosquito   459 DECADAPCRNGGTCIDLIGKFRCECPPQWTGDTCQNDVDECE----------------------S 501

  Fly   557 NLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQCRNG 621
            |::|                .:||||||:.|||.||||.|.|.|||||.|||:|||||||:|:||
Mosquito   502 NVAS----------------GLGPCINAESCRNLPGSFQCTCLEGWGGPTCAKNLDDCVGKCKNG 550

  Fly   622 ATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAK 686
            ||||||||||.||||.|:.||||.|||:|||..||||||||||.:|.|.||||||:||:||||||
Mosquito   551 ATCIDLVNDYHCACAVGYTGRDCSTDINECANFPCRNGGECVDFIGNFKCICPLGFSGTLCEEAK 615

  Fly   687 ENCTPSPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLC---SQPPCNEGCFANVSLATSATTT 748
            ::|..|||:||.|||||.||||||||.|||:|||..|..|   |||.|:..||:..|...:..|.
Mosquito   616 DHCVSSPCIEGQCLNTPGGYYCHCPPGRAGRHCEFPRVPCEKASQPGCSSACFSQCSRNEAGCTM 680

  Fly   749 TTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCRNGGIC 813
            .|:..||.:...:..|  :||||.|.||...:||.|.|..|.||.||:||:|||:.|||.|.|||
Mosquito   681 PTSNDTAISGGPIVVP--IPCSGRGKCESGPMGTSCVCQSGFTGPFCQHNVNECTSNPCANNGIC 743

  Fly   814 LDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMP----GAPDKALQPHCRCAPGWTGLF 874
            :||:||::|||..|||||.|:|||..|..|||.|||:|:|    ||      |||||..||.|.|
Mosquito   744 IDGEGDYSCECQPGWTGKTCTERAIQCLPGQCLNGGSCIPSQFGGA------PHCRCTLGWGGPF 802

  Fly   875 CAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYS 939
            |:|.:|||:|||||||||||||.|||||:||:|||||||||||||||||||.|||||.|||||::
Mosquito   803 CSEPLDQCQGQPCHNGGTCESGPGWFRCLCAKGFSGPDCRINVNECSPQPCLGGATCKDGIGGFT 867

  Fly   940 CICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRT-----EDDENCNAC 999
            ||||.||.|:|||||||||.|.|.| :.|.|||..|..|.:.....:.|..     .|:.|||:|
Mosquito   868 CICPVGRRGVRCEILLSDPSSVCSN-TTTNSPYDPLVSSDSLSKPKVGGAAASQAPSDETNCNSC 931

  Fly  1000 VCENGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETCLSSPCNVRGDCRALEP 1064
            :|.||..||:||||||.||..   .::||.:...|:.|:||||...|:||:.||..|||||..||
Mosquito   932 ICVNGKPRCSNLWCGLNNCLN---RNQSSGVGSGCESHQVCVPTSQESCLTPPCQPRGDCRTFEP 993

  Fly  1065 SRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGASVEGLCSLVRVLLAAQLIKKPA- 1128
            |||||||::||.:.||||||.:...|||::|||.|.|:.:|.||:|||.|:|:.|..:|||.|:
Mosquito   994 SRRVAPPKIPAPTDCWPNQATLGTACARISILLELNRLVRGTSVDGLCHLLRLQLGEKLIKNPSF 1058

  Fly  1129 --STFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDP-----QLPVAVGLLGELLSFRQLNGIQ 1186
              |.|      :::|||||.|||||:|:|:.||...||     .|..||.||.|:||.:|  |:|
Mosquito  1059 DVSVF------IVLLCDLKAGTNDTIEVTLVSSTPTDPVGGASSLTEAVRLLAEILSRQQ--GVQ 1115

  Fly  1187 RRKELELQHAKLAALTSIVEVKLETARVADGS-GHSLLIGVLCGVFIVLVGFSVFISLYWKQRLA 1250
             ....:....:.|.||||:|||:|||.|.:|| |.:.||.|..|:.||.:.....::|.|:|::.
Mosquito  1116 -NDSFQTDLVEAAPLTSILEVKVETALVNEGSTGSNYLIAVGFGIAIVALCLGAVVALLWRQKVH 1179

  Fly  1251 YRTSSGMNLTPSLDALR-HEEEKSNNLQNEENLRRYTNPLKGSTSSLRAATGMELSLNPAPELAA 1314
            ..:.||.||:|.||..| .:||||||||||||.|||.||||.|:||||.|  ||||||||||:..
Mosquito  1180 SHSGSGTNLSPHLDLSRGMDEEKSNNLQNEENFRRYANPLKASSSSLRGA--MELSLNPAPEINQ 1242

  Fly  1315 SAASSSALHRSQPLFPPC-----DFERELDSSTGLKQAHKRSSQILLHKTQNSD-MRKNTVGSLD 1373
            .|..||..||||.|:|||     :||::.|.    ::|..|:|.||||||||:| |.||.||::|
Mosquito  1243 IAGPSSVHHRSQQLYPPCTPDGAEFEKDPDK----QKAANRNSHILLHKTQNADIMTKNIVGAID 1303

  Fly  1374 SPRKDFGKRSIN 1385
            |..|||||||||
Mosquito  1304 SQHKDFGKRSIN 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	52/95 (55%)
		DSL	220..282	CDD:279722	47/61 (77%)
		EGF_CA	350..388	CDD:238011	32/37 (86%)
		EGF_CA	490..526	CDD:238011	27/35 (77%)
		EGF_CA	610..645	CDD:238011	28/34 (82%)
		EGF_CA	647..683	CDD:238011	26/35 (74%)
		EGF_CA	798..833	CDD:238011	23/34 (68%)
		EGF_CA	879..913	CDD:238011	28/33 (85%)
		EGF_CA	916..952	CDD:238011	28/35 (80%)
		VWC_out	<993..1053	CDD:214565	28/59 (47%)
AgaP_AGAP004154	XP_313038.5	MNNL	16..112	CDD:284966	52/95 (55%)
		DSL	171..233	CDD:279722	47/61 (77%)
		EGF_CA	301..339	CDD:238011	32/37 (86%)
		EGF_CA	457..493	CDD:238011	27/35 (77%)
		EGF_CA	495..536	CDD:238011	28/78 (36%)
		EGF_CA	539..573	CDD:238011	27/33 (82%)
		EGF_CA	576..612	CDD:238011	26/35 (74%)
		EGF_CA	616..649	CDD:238011	23/32 (72%)
		EGF_CA	728..764	CDD:238011	23/35 (66%)
		EGF_CA	808..841	CDD:238011	28/32 (88%)
		EGF_CA	844..880	CDD:238011	28/35 (80%)
		VWC_out	<926..982	CDD:214565	28/58 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	396	1.000	Domainoid score	I2201
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H180
Inparanoid	1	1.050	1649	1.000	Inparanoid score	I266
OMA	1	1.010	-	-		QHG45993
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	1	1.000	-	-		FOG0003067
OrthoInspector	1	1.000	-	-		oto105624
Panther	1	1.100	-	-	LDO	PTHR24044
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2046
TreeFam	1	0.960	-	-
	13	12.940