Protein Alignment Ser and Ser

DIOPT Version :10

• Sequence 1: NP_524527.3
• Gene: Ser / 43275
• FlyBaseID: FBgn0004197
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_061507008.1
• Gene: Ser / 1273981
• VectorBaseID: AGAMI1_015117
• Length: 1367
• Species: Anopheles gambiae
• Alignment Length: 1399
• Identity: 817/1399 - (58%)
• Similarity: 972/1399 - (69%)
• Gaps: 158/1399 - (11%)

  Fly    56 IRDCRSLKSACNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGC 120
            |.|.||..|    :.::::.|:..:|::|.|||:||||||||||||:|||||:|.|.|.|:|.||
Mosquito     3 IGDLRSWTS----VVVVILTLISMVSSSGFFELQILEISNTNSHLLSGYCCGLPPEKRQTQTTGC 63

  Fly   121 SPCTTAFRLCLKEYQTT------------------EQGASISTGCSFGNATTKILGGSSFVLSDP 167
            ..|.|||.|||||||.|                  |...|...||:||||:|.:||||||||:||
Mosquito    64 PACATAFSLCLKEYQGTTSSVQQQQQQLKQPAVAVEPQPSGLYGCAFGNASTPVLGGSSFVLTDP 128

  Fly   168 GVGAIVLPFTFRWTKSFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARI 232
            .||.|.||||||||||||||||||||||.||..:||||:|||:|||||||.:|.||||||::|||
Mosquito   129 EVGGITLPFTFRWTKSFTLILQALDMYNESYSISERLIDETSFSGVILPSHDWNTLDHIGKSARI 193

  Fly   233 TYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGK 297
            |||||||||..|||||||||||||:||||||.||.:|.|:|:.||||.|||:||||.|||.:|||
Mosquito   194 TYRVRVQCADNYYNTTCTTFCRPRNDQFGHYTCGKQGNKVCMPGWQGANCEKAICKPGCDQIHGK 258

  Fly   298 CDRPGECECRPGWRGPLCNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKH 362
            ||:||||||||||||||||||||||||:||.||||||:|:|||||||||||||||:|||||||.|
Mosquito   259 CDQPGECECRPGWRGPLCNECMVYPGCRHGYCNGSAWQCICDTNWGGILCDQDLNYCGTHEPCMH 323

  Fly   363 GGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQ--------VYR 419
            ||||||||||:|||||||||||.:|||||||||.:||:|||||||..::::.|.        |.|
Mosquito   324 GGTCENTAPDQYRCTCAEGLSGTRCEIVEHPCAPQPCKNGGTCTLTGNDKSAAVASSTVASIVVR 388

  Fly   420 TSHGRSNMGRPVRRS-----------SSMRSLDHLRPEGQALNG--SSSPGL--VSLGSLQLQQQ 469
            ...|.|:||:|..||           |...:||   .:.||.:|  |||.||  .|.|..|..:
Mosquito   389 GMRGMSSMGKPFGRSAAGTGGGSSAGSGSGTLD---SKDQAKSGSSSSSAGLPAPSAGGPQPMK- 449

  Fly   470 LAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEA 534
               ||.|.||.|||||||||||||||..||.:|||||||||.|||||||:|.||.||.||:|||
Mosquito   450 ---DFVCTCAPGWTGPTCEINIDECADAPCRNGGTCIDLIGKFRCECPPQWTGDTCQNDVDECE- 510

  Fly   535 PHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICK 599
                                 ||::|                .:||||||:.|||.||||.|.|.
Mosquito   511 ---------------------SNVAS----------------GLGPCINAESCRNLPGSFQCTCL 538

  Fly   600 EGWGGVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVD 664
            |||||.|||:|||||||:|:||||||||||||.||||.|:.||||.|||:|||..||||||||||
Mosquito   539 EGWGGPTCAKNLDDCVGKCKNGATCIDLVNDYHCACAVGYTGRDCSTDINECANFPCRNGGECVD 603

  Fly   665 MVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQ- 728
            .:|.|.||||||:||:||||||::|..|||:||.|||||.||||||||.|||:|||..|..|.:
Mosquito   604 FIGNFKCICPLGFSGTLCEEAKDHCVSSPCIEGQCLNTPGGYYCHCPPGRAGRHCEFPRVPCEKG 668

  Fly   729 PPC-NE-GCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCKCHVGHT 791
            .|| || ||           |..|:..||.:...:..|  :||||.|.||...:||.|.|..|.|
Mosquito   669 GPCANEAGC-----------TMPTSNDTAISGGPIVVP--IPCSGRGKCESGPMGTSCVCQSGFT 720

  Fly   792 GTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMP--- 853
            |.||:||:|||:.|||.|.|||:||:||::|||..|||||.|:|||..|..|||.|||:|:|
Mosquito   721 GPFCQHNVNECTSNPCANNGICIDGEGDYSCECQPGWTGKTCTERAIQCLPGQCLNGGSCIPSQF 785

  Fly   854 -GAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINV 917
             ||      |||||..||.|.||:|.:|||:|||||||||||||.|||||:||:|||||||||||
Mosquito   786 GGA------PHCRCTLGWGGPFCSEPLDQCQGQPCHNGGTCESGPGWFRCLCAKGFSGPDCRINV 844

  Fly   918 NECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWL 982
            ||||||||.|||||.|||||::||||.||.|:|||||||||.|.|.| :.|.|||..|..|.:..
Mosquito   845 NECSPQPCLGGATCKDGIGGFTCICPVGRRGVRCEILLSDPSSVCSN-TTTNSPYDPLVSSDSLS 908

  Fly   983 -----DIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKVDPLSKSSNLSGVCKQHEVCVP 1042
                 ..|.:....|:.|||:|:|.||..||:||||||.||..   .::||.:...|:.|:||||
Mosquito   909 KPKDGGAAASQAPSDETNCNSCICVNGKPRCSNLWCGLNNCLN---RNQSSGVGSGCESHQVCVP 970

  Fly  1043 ALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVGKGAS 1107
            ...|:||:.||..|||||..|||||||||::||.:.||||||.:...|||::|||.|.|:.:|.|
Mosquito   971 TSQESCLTPPCQPRGDCRTFEPSRRVAPPKIPAPTDCWPNQATLGTACARISILLELNRLVRGTS 1035

  Fly  1108 VEGLCSLVRVLLAAQLIKKPA---STFGQDPGMLMVLCDLKTGTNDTVELTVSSSKLNDP----- 1164
            |:|||.|:|:.|..:|||.|:   |.|      ::||||||.|||||:|:|:|:.  .||
Mosquito  1036 VDGLCHLLRLQLGEKLIKNPSFDVSVF------IVVLCDLKAGTNDTIEVTLSTP--TDPVGGAS 1092

  Fly  1165 QLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALTSIVEVKLETARVADGS-GHSLLIGVLC 1228
            .|..||.||.|:||.:|  |:| ....:....:.|.||||:|||:|||.|.:|| |.:.||.|..
Mosquito  1093 SLTEAVRLLAEILSRQQ--GVQ-NDSFQTDLVEAAPLTSILEVKVETALVNEGSTGSNYLIAVGF 1154

  Fly  1229 GVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLDALR-HEEEKSNNLQNEENLRRYTNPLKGS 1292
            |:.||.:.....::|.|:|::...:.||.||:|.||..| .:||||||||||||.|||.||||.|
Mosquito  1155 GIAIVALCLGAVVALLWRQKVHSHSGSGTNLSPHLDLSRGMDEEKSNNLQNEENFRRYANPLKAS 1219

  Fly  1293 TSSLRAATGMELSLNPAPELAASAASSSALHRSQPLFPPC-----DFERELDSSTGLKQAHKRSS 1352
            :||||.|  ||||||||||:...|..||..||||.|:|||     :||::.|.    ::|..|:|
Mosquito  1220 SSSLRGA--MELSLNPAPEINQIAGPSSVHHRSQQLYPPCTPDGAEFEKDPDK----QKAANRNS 1278

  Fly  1353 QILLHKTQNSD-MRKNTVGSLDSPRKDFGKRSIN 1385
            .||||||||:| |.||.||::||..|||||||||
Mosquito  1279 HILLHKTQNADIMTKNIVGAIDSQHKDFGKRSIN 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_524527.3	MNNL	83..238	CDD:462222	114/172 (66%)
		DSL	220..282	CDD:128366	47/61 (77%)
		EGF_CA	350..388	CDD:238011	32/37 (86%)
		EGF_CA	490..526	CDD:238011	27/35 (77%)
		EGF_CA	610..645	CDD:238011	28/34 (82%)
		EGF_CA	647..683	CDD:238011	26/35 (74%)
		EGF_CA	690..720	CDD:238011	22/29 (76%)
		EGF_CA	798..833	CDD:238011	23/34 (68%)
		EGF_CA	879..913	CDD:238011	28/33 (85%)
		EGF_CA	916..952	CDD:238011	28/35 (80%)
		VWC_out	<993..1053	CDD:214565	28/59 (47%)
Ser	XP_061507008.1	None