DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and AgaP_AGAP010940

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_309755.4	Gene:	AgaP_AGAP010940 / 1271013	VectorBaseID:	AGAP010940	Length:	340	Species:	Anopheles gambiae

Alignment Length:	400	Identity:	115/400 - (28%)
Similarity:	146/400 - (36%)	Gaps:	151/400 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 DQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECMVYP 322
            :::.||.|...|...||.||.|..|:..|||.||||:.|.|.|||||.|:.|:.|..||.|:..|
Mosquito    14 NEYSHYVCDDNGDVKCLPGWTGDLCDVPICKKGCDPLQGYCKRPGECRCKLGFYGENCNRCIPLP 78

  Fly   323 GCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQC 387
            ||:||.|..| ::|||...|.||.|.:.:.....| |.:  |.||  ||.:  |.|..|.:|..|
Mosquito    79 GCQHGGCQVS-FECVCHKGWDGIFCSEPICRSDCH-PSR--GYCE--APGE--CRCRLGWAGPTC 135

  Fly   388 EIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNG 452
                ..|...|....||||                      :|:.
Mosquito   136 ----RDCQVLPGCMHGTCT----------------------KPLE-------------------- 154

  Fly   453 SSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAG------GPCEHGGTCIDLIGG 511
                                   |.|..||||..|:..|  ||.      |.|...|
Mosquito   155 -----------------------CKCLPGWTGILCQTPI--CAANCSREHGYCRRPG-------- 186

  Fly   512 FRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSL 576
             .|.|...|.|..|    |:|. |:..
Mosquito   187 -ECRCKVGWMGQEC----NKCH-PYPG-------------------------------------- 207

  Fly   577 AIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDC---VGQCRNGATCIDLVND---YRCAC 635
                |:|. :||.   .:.|.||.||||:.|.|.|:.|   ...|:||..|..::.|   |||.|
Mosquito   208 ----CVNG-DCRR---PWECNCKPGWGGMLCDEELNYCEQNPDTCQNGGKCKSVIKDDGHYRCEC 264

  Fly   636 ASGFKGRDCE 645
            .||:|||:||
Mosquito   265 PSGYKGRNCE 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	9/23 (39%)
		EGF_CA	350..388	CDD:238011	11/37 (30%)
		EGF_CA	490..526	CDD:238011	10/41 (24%)
		EGF_CA	610..645	CDD:238011	16/40 (40%)
		EGF_CA	647..683	CDD:238011
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
AgaP_AGAP010940	XP_309755.4	DSL	<16..38	CDD:302925	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46730at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920