DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and AgaP_AGAP001015

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_309208.5	Gene:	AgaP_AGAP001015 / 1270506	VectorBaseID:	AGAP001015	Length:	2800	Species:	Anopheles gambiae

Alignment Length:	1350	Identity:	349/1350 - (25%)
Similarity:	487/1350 - (36%)	Gaps:	436/1350 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LPSTIRDCRS-----LKSACNLIALI------LILLVHKISAAGNFELEILEISNTN---SHL-- 100
            ||.|...|.:     |.|....:.::      |..::.|.|.:.:|:.:..| .||:   .:|
Mosquito   249 LPRTANSCFNQRTIGLSSTTKTVMMVSCVLNALFNMIEKQSGSNSFQGKNCE-ENTDDCPGNLCQ 312

  Fly   101 --------LNGYCCGMPAE--------------LR---------ATKTIGCSPCTTAFRLCLKEY 134
                    :|.|.|..|:.              ||         .|.|.|...|     :|:..:
Mosquito   313 NGGTCVDGINAYHCSCPSSFTGEFCENDVDECALRPSICQNGATCTNTHGSYNC-----ICVNGW 372

  Fly   135 QTTEQGASI----STGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDMYN 195
            ...:...:|    ...| |..||           ...|||:    |..|.|...|.:|..||...
Mosquito   373 NGPDCSNNIDDCVDAAC-FNGAT-----------CIDGVGS----FYCRCTPGKTGLLCHLDDAC 421

  Fly   196 TSYP-DAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCRPRDDQ 259
            ||.| .|:.:.:.:..:|                                 :.||:
Mosquito   422 TSNPCHADAICDTSPING---------------------------------SFTCS--------- 444

  Fly   260 FGHYACGSEGQKLCLNGWQGVNCEEAI--CKAGCDPVH-GKC-DRPGE--CECRPGWRGPLC--- 315
                         |..|::|::|.|.|  |..|....| |.| :.||.  |.|..|:.||.|
Mosquito   445 -------------CAVGYKGIDCSEDIDECDQGSPCEHNGICVNTPGSFACNCSQGFTGPRCETN 496

  Fly   316 -NECMVYPGCKHGSC--NGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCT 377
             |||..:|....|||  :...::|||...:.|..|:.|::.|.|: ||.:||.|.:.. :.::||
Mosquito   497 VNECESHPCQNQGSCLDDPGTFRCVCMPGYTGTQCEIDIDECATN-PCLNGGICRDMV-NSFKCT 559

  Fly   378 CAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDH 442
            ||.|.||.:|:|....|.::||||||.|    .:...........|.:.:......:....:..|
Mosquito   560 CAIGFSGLRCQINIDDCMSQPCRNGGIC----HDSIAGYSCECQPGYTGLSCETNINDCQSNPCH 620

  Fly   443 LRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCID 507
               .|..::|.:|                  |||.|..|:||..|:|.|:||...||..||.|.|
Mosquito   621 ---RGACIDGDNS------------------FTCLCNPGYTGYLCQIQINECESNPCLFGGHCED 664

  Fly   508 LIGGFRCECPPEWHGDVCQVDVNECEA-PHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAV 571
            |:||:.|.|.|...|..|:|:||||.: |...|          |..|.|.|..:...:...|...
Mosquito   665 LVGGYMCRCQPGTSGPNCEVNVNECHSNPCRNG----------AKCIDGINRYTCQCVPGYTGFH 719

  Fly   572 ASTSL-----------------------------------------AIGPCINAKECRNQPGSFA 595
            ..|::                                         |..||||...|.:....|.
Mosquito   720 CETNINECASDPCANGGVCMDLVNGFRCECPRGYFDARCLSDVDECASNPCINGGRCEDGVNQFI 784

  Fly   596 CICKEGWGGVTCAENLDDC-VGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNG 659
            |.|..|:||..|..::|:| ...|::|..|.|.:|.|.|.|..|:.||:||.:||:|..:|||||
Mosquito   785 CHCPPGYGGRRCEIDIDECGSNPCQHGGICRDGLNAYTCQCMPGYTGRNCEINIDDCVNNPCRNG 849

  Fly   660 GECVDMVGKFNCI----------------------------------------CPLGYSGSLCEE 684
            |.|:|:|..:.|:                                        |.|||:|.||:|
Mosquito   850 GSCIDLVNGYKCVCRGPFTGRDCESKMDPCQPNRCRNGAKCSPSPNYLDFACSCTLGYTGRLCDE 914

  Fly   685 AKENCT-PSPCLEG----------HC------------LNTPE-----------------GYYCH 709
            ....|. .|||..|          ||            :||.:                 .|.|.
Mosquito   915 DINECALSSPCRHGATCRNTNGSYHCICAKGYEGRDCTINTDDCASFPCQNGGTCLDGIGDYTCL 979

  Fly   710 CPPDRAGKHCEQLRPLCSQPPCNEGCFAN---------VSLATSATTTTTTTTTATTTRKMAKPS 765
            |.....|||||.....|...||..|...|         ..|..|.....|.....|.:
Mosquito   980 CVDGFEGKHCEVDINECLSMPCQNGATCNQYVNSYTCTCPLGFSGMNCQTNDEDCTES------- 1037

  Fly   766 GLPCSGHGSCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWT 829
              .|...|:| :..:.:: |.|..|:||:.|::.:|:|...|||||..|.|.:.|:||.|..|:|
Mosquito  1038 --SCMNGGTC-IDGINSYNCSCETGYTGSNCQYRINKCDSQPCRNGATCHDYENDYTCHCSYGYT 1099

  Fly   830 GKRCSERATGCYAGQCQNGGTC-----------------------MPGAPDKALQP--------- 862
            ||:|.|....|....|:||.||                       |....|.|.:.
Mosquito  1100 GKQCLEYVDWCSQNPCENGATCTQQENTYHCACAAGWTGKLCDVEMVSCKDAAARKGVDAKHLCH 1164

  Fly   863 -----------HCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRIN 916
                       .||||.|:||.:|...|::|..|||.|||||::..|.:||.|..||.|.:|.:|
Mosquito  1165 NGTCEDFGNSHRCRCARGYTGSYCHHEINECESQPCRNGGTCKNLIGSYRCQCRAGFQGQNCELN 1229

  Fly   917 VNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSD-PKSACQNASNTISPYTALN-RSQ 979
            ::||.|.||:.|..|.|.:.||.|.||||..|:.|||...| ...||.|..:.:....... |..
Mosquito  1230 IDECKPNPCRNGGICHDLVNGYKCSCPPGTIGVLCEINTDDCTPGACHNNGSCVDKVGGFECRCP 1294

  Fly   980 NWLDIALTGRTEDDEN-CNACVCEN-GTSRCTNL----WCGLPNCYKVDPLSKSSNLSGVCKQHE 1038
            ...   :..|.|.|.| |.:..|.| ||..|..|    .|   ||       |..::...|   |
Mosquito  1295 PGF---VGARCEGDINECLSNPCSNPGTLDCVQLVNDYHC---NC-------KPGHMGRHC---E 1343

  Fly  1039 VCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVG 1103
            |.|    :.|.:|||...|.|...:....           |........:||         |..|
Mosquito  1344 VKV----DFCANSPCLNGGQCSTRQSGHH-----------CVCADGYYGKNC---------EFSG 1384

  Fly  1104 ----KGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTN 1149
                ....:.|||.:                 ..|.|   ..||...||:
Mosquito  1385 HDCDSNPCINGLCQI-----------------ADDGG---YRCDCPLGTS 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	21/117 (18%)
		DSL	220..282	CDD:279722	5/61 (8%)
		EGF_CA	350..388	CDD:238011	15/37 (41%)
		EGF_CA	490..526	CDD:238011	16/35 (46%)
		EGF_CA	610..645	CDD:238011	13/35 (37%)
		EGF_CA	647..683	CDD:238011	19/75 (25%)
		EGF_CA	798..833	CDD:238011	17/34 (50%)
		EGF_CA	879..913	CDD:238011	17/33 (52%)
		EGF_CA	916..952	CDD:238011	17/35 (49%)
		VWC_out	<993..1053	CDD:214565	19/65 (29%)
AgaP_AGAP001015	XP_309208.5	EGF_CA	145..181	CDD:238011
		EGF_CA	302..338	CDD:238011	7/35 (20%)
		EGF_CA	340..377	CDD:238011	7/41 (17%)
		EGF_CA	380..415	CDD:238011	12/50 (24%)
		EGF_CA	457..494	CDD:238011	13/36 (36%)
		EGF_CA	496..532	CDD:238011	11/35 (31%)
		EGF_CA	534..570	CDD:238011	15/37 (41%)
		EGF_CA	572..608	CDD:238011	9/39 (23%)
		EGF_CA	610..645	CDD:238011	11/55 (20%)
		EGF_CA	648..683	CDD:238011	16/34 (47%)
		EGF_CA	685..721	CDD:238011	11/45 (24%)
		EGF_CA	723..758	CDD:238011	0/34 (0%)
		EGF_CA	761..797	CDD:238011	12/35 (34%)
		EGF_CA	799..835	CDD:238011	13/35 (37%)
		EGF_CA	837..873	CDD:238011	13/35 (37%)
		EGF_CA	915..952	CDD:238011	7/36 (19%)
		EGF_CA	954..990	CDD:238011	8/35 (23%)
		EGF_CA	992..1028	CDD:238011	7/35 (20%)
		EGF_CA	1035..1066	CDD:238011	9/40 (23%)
		EGF_CA	1069..1103	CDD:238011	17/33 (52%)
		EGF_CA	1111..1141	CDD:238011	5/29 (17%)
		EGF_CA	1192..1227	CDD:238011	17/34 (50%)
		EGF_CA	1229..1265	CDD:238011	17/35 (49%)
		EGF_CA	1267..1303	CDD:238011	6/38 (16%)
		EGF_CA	1305..1343	CDD:238011	14/50 (28%)
		EGF_CA	1346..1381	CDD:238011	10/58 (17%)
		EGF_CA	1424..1457	CDD:238011
		Notch	1498..1532	CDD:278494
		Notch	1538..1573	CDD:278494
		Notch	1585..1613	CDD:278494
		NOD	1619..1670	CDD:284282
		NODP	1699..1755	CDD:284987
		Ank_2	<1929..2016	CDD:289560
		ANK	1937..2073	CDD:238125
		ANK repeat	1939..1983	CDD:293786
		ANK repeat	1986..2016	CDD:293786
		Ank_5	2005..2060	CDD:290568
		ANK	2013..2139	CDD:238125
		ANK repeat	2019..2050	CDD:293786
		ANK repeat	2052..2083	CDD:293786
		Ank_2	2057..2149	CDD:289560
		ANK repeat	2085..2116	CDD:293786
		ANK repeat	2118..2149	CDD:293786
		DUF3454	2723..2778	CDD:288764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4289at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820