Protein Alignment Ser and N

DIOPT Version :10

• Sequence 1: NP_524527.3
• Gene: Ser / 43275
• FlyBaseID: FBgn0004197
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_061518958.1
• Gene: N / 1270506
• VectorBaseID: AGAMI1_005153
• Length: 2782
• Species: Anopheles gambiae
• Alignment Length: 1275
• Identity: 338/1275 - (26%)
• Similarity: 465/1275 - (36%)
• Gaps: 397/1275 - (31%)

  Fly    81 SAAGNF-ELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLKEYQTTEQGASI- 143
            |..|.| |.::.|.:...|...||..|        |.|.|...|     :|:..:...:...:|
Mosquito   299 SFTGEFCENDVDECALRPSICQNGATC--------TNTHGSYNC-----ICVNGWNGPDCSNNID 350

  Fly   144 ---STGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYP-DAERL 204
               ...| |..||           ...|||:    |..|.|...|.:|..||...||.| .|:.:
Mosquito   351 DCVDAAC-FNGAT-----------CIDGVGS----FYCRCTPGKTGLLCHLDDACTSNPCHADAI 399

  Fly   205 IEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEG 269
            .:.:..:|                                 :.||:
Mosquito   400 CDTSPING---------------------------------SFTCS------------------- 412

  Fly   270 QKLCLNGWQGVNCEEAI--CKAGCDPVH-GKC-DRPGE--CECRPGWRGPLC----NECMVYPGC 324
               |..|::|::|.|.|  |..|....| |.| :.||.  |.|..|:.||.|    |||..:|..
Mosquito   413 ---CAVGYKGIDCSEDIDECDQGSPCEHNGICVNTPGSFACNCSQGFTGPRCETNVNECESHPCQ 474

  Fly   325 KHGSC--NGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQC 387
            ..|||  :...::|||...:.|..|:.|::.|.|: ||.:||.|.:.. :.::||||.|.||.:|
Mosquito   475 NQGSCLDDPGTFRCVCMPGYTGTQCEIDIDECATN-PCLNGGICRDMV-NSFKCTCAIGFSGLRC 537

  Fly   388 EIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNG 452
            :|....|.::||||||.|    .:...........|.:.:......:....:..|   .|..::|
Mosquito   538 QINIDDCMSQPCRNGGIC----HDSIAGYSCECQPGYTGLSCETNINDCQSNPCH---RGACIDG 595

  Fly   453 SSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECP 517
            .:|                  |||.|..|:||..|:|.|:||...||..||.|.||:||:.|.|.
Mosquito   596 DNS------------------FTCLCNPGYTGYLCQIQINECESNPCLFGGHCEDLVGGYMCRCQ 642

  Fly   518 PEWHGDVCQVDVNECEA-PHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSL----- 576
            |...|..|:|:||||.: |...|          |..|.|.|..:...:...|.....|::
Mosquito   643 PGTSGPNCEVNVNECHSNPCRNG----------AKCIDGINRYTCQCVPGYTGFHCETNINECAS 697

  Fly   577 ------------------------------------AIGPCINAKECRNQPGSFACICKEGWGGV 605
                                                |..||||...|.:....|.|.|..|:||.
Mosquito   698 DPCANGGVCMDLVNGFRCECPRGYFDARCLSDVDECASNPCINGGRCEDGVNQFICHCPPGYGGR 762

  Fly   606 TCAENLDDC-VGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKF 669
            .|..::|:| ...|::|..|.|.:|.|.|.|..|:.||:||.:||:|..:||||||.|:|:|..:
Mosquito   763 RCEIDIDECGSNPCQHGGICRDGLNAYTCQCMPGYTGRNCEINIDDCVNNPCRNGGSCIDLVNGY 827

  Fly   670 NCI----------------------------------------CPLGYSGSLCEEAKENCT-PSP 693
            .|:                                        |.|||:|.||:|....|. .||
Mosquito   828 KCVCRGPFTGRDCESKMDPCQPNRCRNGAKCSPSPNYLDFACSCTLGYTGRLCDEDINECALSSP 892

  Fly   694 CLEG----------HC------------LNTPE-----------------GYYCHCPPDRAGKHC 719
            |..|          ||            :||.:                 .|.|.|.....||||
Mosquito   893 CRHGATCRNTNGSYHCICAKGYEGRDCTINTDDCASFPCQNGGTCLDGIGDYTCLCVDGFEGKHC 957

  Fly   720 EQLRPLCSQPPCNEGCFAN---------VSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSC 775
            |.....|...||..|...|         ..|..|.....|.....|.:         .|...|:|
Mosquito   958 EVDINECLSMPCQNGATCNQYVNSYTCTCPLGFSGMNCQTNDEDCTES---------SCMNGGTC 1013

  Fly   776 EMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATG 839
             :..:.:: |.|..|:||:.|::.:|:|...|||||..|.|.:.|:||.|..|:|||:|.|....
Mosquito  1014 -IDGINSYNCSCETGYTGSNCQYRINKCDSQPCRNGATCHDYENDYTCHCSYGYTGKQCLEYVDW 1077

  Fly   840 CYAGQCQNGGTC-----------------------MPGAPDKALQP------------------- 862
            |....|:||.||                       |....|.|.:.
Mosquito  1078 CSQNPCENGATCTQQENTYHCACAAGWTGKLCDVEMVSCKDAAARKGVDAKHLCHNGTCEDFGNS 1142

  Fly   863 -HCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQ 926
             .||||.|:||.:|...|::|..|||.|||||::..|.:||.|..||.|.:|.:|::||.|.||:
Mosquito  1143 HRCRCARGYTGSYCHHEINECESQPCRNGGTCKNLIGSYRCQCRAGFQGQNCELNIDECKPNPCR 1207

  Fly   927 GGATCIDGIGGYSCICPPGRHGLRCEILLSD-PKSACQNASNTISPYTALN-RSQNWLDIALTGR 989
            .|..|.|.:.||.|.||||..|:.|||...| ...||.|..:.:....... |.....   :..|
Mosquito  1208 NGGICHDLVNGYKCSCPPGTIGVLCEINTDDCTPGACHNNGSCVDKVGGFECRCPPGF---VGAR 1269

  Fly   990 TEDDEN-CNACVCEN-GTSRCTNL----WCGLPNCYKVDPLSKSSNLSGVCKQHEVCVPALSETC 1048
            .|.|.| |.:..|.| ||..|..|    .|   ||       |..::...|   ||.|    :.|
Mosquito  1270 CEGDINECLSNPCSNPGTLDCVQLVNDYHC---NC-------KPGHMGRHC---EVKV----DFC 1317

  Fly  1049 LSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERVG----KGASVE 1109
            .:|||...|.|...:....           |........:||         |..|    ....:.
Mosquito  1318 ANSPCLNGGQCSTRQSGHH-----------CVCADGYYGKNC---------EFSGHDCDSNPCIN 1362

  Fly  1110 GLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTN 1149
            |||.:                 ..|.|   ..||...||:
Mosquito  1363 GLCQI-----------------ADDGG---YRCDCPLGTS 1382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_524527.3	MNNL	83..238	CDD:462222	33/160 (21%)
		DSL	220..282	CDD:128366	5/61 (8%)
		EGF_CA	350..388	CDD:238011	15/37 (41%)
		EGF_CA	490..526	CDD:238011	16/35 (46%)
		EGF_CA	610..645	CDD:238011	13/35 (37%)
		EGF_CA	647..683	CDD:238011	19/75 (25%)
		EGF_CA	690..720	CDD:238011	14/69 (20%)
		EGF_CA	798..833	CDD:238011	17/34 (50%)
		EGF_CA	879..913	CDD:238011	17/33 (52%)
		EGF_CA	916..952	CDD:238011	17/35 (49%)
		VWC_out	<993..1053	CDD:214565	19/65 (29%)
N	XP_061518958.1	None