DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and WIF1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_009122.2	Gene:	WIF1 / 11197	HGNCID:	18081	Length:	379	Species:	Homo sapiens

Alignment Length:	256	Identity:	79/256 - (30%)
Similarity:	97/256 - (37%)	Gaps:	89/256 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   486 TCEINIDECAGGPCEHGGTCIDLIGGFR--CECPPEWHGDVCQVDVNECEAPHSAGIAANALLTT 548
            ||:  ..||.|| |.:||.|.:     |  ||||..:||..|:                .||.|.
Human   176 TCQ--QAECPGG-CRNGGFCNE-----RRICECPDGFHGPHCE----------------KALCTP 216

  Fly   549 TATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDD 613
            .                               |:|...|.. ||  .|||..|:.||.|  :..:
Human   217 R-------------------------------CMNGGLCVT-PG--FCICPPGFYGVNC--DKAN 245

  Fly   614 CVGQCRNGATCIDLVNDY--RCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLG 676
            |...|.||.||.     |  :|.|..|.:|..||  |.:| ..||||||:|   :||..|.|..|
Human   246 CSTTCFNGGTCF-----YPGKCICPPGLEGEQCE--ISKC-PQPCRNGGKC---IGKSKCKCSKG 299

  Fly   677 YSGSLCEEAKENCTPSPCLEGHCLNTPEGYYCHCPPDRAGKHCEQ---------LRPLCSQ 728
            |.|.||  :|..|.|.....|.|   .|...|.|.....|:||.:         |||..:|
Human   300 YQGDLC--SKPVCEPGCGAHGTC---HEPNKCQCQEGWHGRHCNKRYEASLIHALRPAGAQ 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011	15/37 (41%)
		EGF_CA	610..645	CDD:238011	11/36 (31%)
		EGF_CA	647..683	CDD:238011	17/35 (49%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
WIF1	NP_009122.2	WIF	35..179	CDD:128745	2/4 (50%)
WIF1	NP_009122.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..379		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910