DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and DLL3

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_058637.1 Gene:DLL3 / 10683 HGNCID:2909 Length:618 Species:Homo sapiens


Alignment Length:669 Identity:167/669 - (24%)
Similarity:219/669 - (32%) Gaps:274/669 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 LILILLVHKISAAGNFELEILEISNTNSHLLN-GYCCGMPAELRATKTIGCS---PCTTAFRLCL 131
            ::.::.:.:...||.|||:|        |... |...|.|..       .||   ||...||:||
Human    15 ILALIFLPQTRPAGVFELQI--------HSFGPGPGPGAPRS-------PCSARLPCRLFFRVCL 64

  Fly   132 KEYQTTEQGASISTGCSFGNATTKILGGSSFVLSD-PGV---------GAIVLPFTFRWTKSFTL 186
            |...:.|...|   .|:.|.|    |.....|.:: ||.         |.:.:||...|..:|:.
Human    65 KPGLSEEAAES---PCALGAA----LSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTFSF 122

  Fly   187 ILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHI-GR-------------------NAR 231
            |:             |...||.   |..:..|.|..|..: ||                   ..|
Human   123 II-------------ETWREEL---GDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELR 171

  Fly   232 ITYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLC--LNGWQGVNCE-EAICKAGCDP 293
            .:||.|  |......|.||..||||.   ....|| .|.:.|  |..    .|| ..:|:|||.|
Human   172 FSYRAR--CEPPAVGTACTRLCRPRS---APSRCG-PGLRPCAPLED----ECEAPLVCRAGCSP 226

  Fly   294 VHGKCDRPGECECRPGWRGPLC------NECM------------VYPGCKHGSCNGSAWKCVCDT 340
            .||.|::||||.|..||.||||      :.|:            :.||  .|.|:|:        
Human   227 EHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPG--PGPCDGN-------- 281

  Fly   341 NWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTC 405
                              ||.:||:|..| |..:.|||..|..|.:||:....||..||.|||.|
Human   282 ------------------PCANGGSCSET-PRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLC 327

  Fly   406 TLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQL 470
            .                                             |.:.|...           
Human   328 V---------------------------------------------GGADPDSA----------- 336

  Fly   471 APDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAP 535
               :.|.|..|:.|..||..:|.|:..||.:||.|:||....||.                    
Human   337 ---YICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCR-------------------- 378

  Fly   536 HSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKE 600
                                                                          |:.
Human   379 --------------------------------------------------------------CRA 381

  Fly   601 GWGGVTCAENLDDCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVD 664
            |:.|..|..:||||.|: |.||.||::....:||:||.||.||||....|.||..||.:||.|..
Human   382 GFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYA 446

  Fly   665 MVGKFNCICPLGYSGSLCE 683
            ......|.|..||.|:.||
Human   447 HFSGLVCACAPGYMGARCE 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966 25/81 (31%)
DSL 220..282 CDD:279722 21/83 (25%)
EGF_CA 350..388 CDD:238011 12/37 (32%)
EGF_CA 490..526 CDD:238011 11/35 (31%)
EGF_CA 610..645 CDD:238011 19/35 (54%)
EGF_CA 647..683 CDD:238011 13/35 (37%)
EGF_CA 798..833 CDD:238011
EGF_CA 879..913 CDD:238011
EGF_CA 916..952 CDD:238011
VWC_out <993..1053 CDD:214565
DLL3NP_058637.1 MNNL 27..84 CDD:284966 24/78 (31%)
DSL 158..248 CDD:302925 36/99 (36%)
EGF_CA 279..310 CDD:238011 13/57 (23%)
EGF 316..349 CDD:278437 14/91 (15%)
EGF_CA 354..389 CDD:238011 14/116 (12%)
EGF_CA 391..426 CDD:238011 18/34 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 546..566
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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