DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and NOTCH2NLC

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001350942.1	Gene:	NOTCH2NLC / 100996717	HGNCID:	53924	Length:	293	Species:	Homo sapiens

Alignment Length:	291	Identity:	95/291 - (32%)
Similarity:	121/291 - (41%)	Gaps:	43/291 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   724 PLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGT-FCKCH 787
            |||.......||                   |....:|.:....||...|.|.....|| :|||.
Human    27 PLCCGRCWRSGC-------------------AARPPRMCRDGYEPCVNEGMCVTYHNGTGYCKCP 72

  Fly   788 VGHTGTFCEHNLNECSPNPCRNGGICLDGD--GDFTCECMSGWTGKRCS-ERATGCYAGQ-CQNG 848
            .|..|.:|:|. :.|..|.|:|||.|:...  |..||.|.||:||:.|. ..:..|:..: |.||
Human    73 EGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNG 136

  Fly   849 GTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDC 913
            |||...:.|..   .|.|..|:||..| :..|.|...||.||.||.:.|..|.|.|..||:|..|
Human   137 GTCHMLSRDTY---ECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKC 197

  Fly   914 RINVNECS-PQPCQGGATCIDGIGGYSCICPPGRHGLRCEIL-LSDPKSACQNASN--------- 967
            ..:||||. |..||.|.||::..|.|.|.|..|..|..|:.| :....|.|.|...
Human   198 ETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTF 262

  Fly   968 --TISPYTALNRSQNW-LDIALTGRTEDDEN 995
              ...|.|....::.| .|..:....|.|||
Human   263 ECNCLPETVRRGTELWERDREVWNGKEHDEN 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011
		EGF_CA	610..645	CDD:238011
		EGF_CA	647..683	CDD:238011
		EGF_CA	798..833	CDD:238011	15/36 (42%)
		EGF_CA	879..913	CDD:238011	15/33 (45%)
		EGF_CA	916..952	CDD:238011	16/36 (44%)
		VWC_out	<993..1053	CDD:214565	3/3 (100%)
NOTCH2NLC	NP_001350942.1	EGF_CA	200..236	CDD:238011	16/35 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910