DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and sned1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_012826283.1	Gene:	sned1 / 100498350	XenbaseID:	XB-GENE-940133	Length:	1667	Species:	Xenopus tropicalis

Alignment Length:	1459	Identity:	343/1459 - (23%)
Similarity:	469/1459 - (32%)	Gaps:	548/1459 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 EILEISNT--------------NSHLLNGYCCGMPAELRATKTIGC---SPCTTAFRLCLKEYQT 136
            :|..|:||              |:|:..|.|        ...|..|   .||....| |:.:..|
Frog   230 DIARIANTTNVGVPGRWVFRIDNNHVQVGEC--------RNATSVCWTLRPCQNGGR-CIDDCVT 285

  Fly   137 TEQGASIS-----TG--C--SFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALD 192
            .....:.|     ||  |  ..|...::........:.:||      .||...|..||..|...:
Frog   286 GNPSYTCSCLSGFTGKHCHIDMGKCYSQPCQNDGTCVDEPG------SFTCLCTSDFTGTLCETE 344

  Fly   193 MYNTSYPDAERLIEETSYSGV-----------------ILPSPEWKTLDHIGRNARITYRVRVQC 240
            :...:|.......|...::|:                 :||......|:. |....|....|.||
Frog   345 VSPCTYMTCHNGGECEDHNGIAVCVCQRGYTGDNCDTELLPCSSSPCLNG-GSCENIDAGFRCQC 408

  Fly   241 AVTYYNTTC-----TTFCRP-------RDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDP 293
            |:.:..|.|     ..|..|       :|...| |.|      :|:.|:.|:.||..|......|
Frog   409 ALGFTGTHCEKEPSACFSSPCMNNGVCKDVGAG-YIC------VCVQGFTGMYCETEIRPCSSAP 466

  Fly   294 V--HGKCDRPGE---CECRPGWRGPLC----NECMVYPGCKHGSCN--GSAWKCVCDTNWGGILC 347
            .  .|.|...||   |:|...:.|..|    ..|...|....|:|.  ...:.|:|...:.||.|
Frog   467 CLNRGVCRENGETYSCQCARRFTGKHCETEIRPCFSNPCMNMGTCEDMSEGYSCICTEGYTGIHC 531

  Fly   348 DQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNR 412
            :.:|..|.: .||.:|..|::.. ..|.|.||.|.:|.:||...|||.:.||.||.||
Frog   532 ETELRPCYS-SPCLNGALCKDFG-ITYSCVCAWGFTGARCETELHPCFSSPCLNGATC------- 587

  Fly   413 TQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCD 477
                                           |..|.|                        ::|.
Frog   588 -------------------------------RDVGFA------------------------YSCQ 597

  Fly   478 CAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAA 542
            ||.|:||..||..|..|...||.:||||.||...|.|.|...:.|..|:.::..|
Frog   598 CAQGFTGMHCETEIKPCFSSPCLNGGTCEDLAISFACLCAERYTGLHCETEIQPC---------- 652

  Fly   543 NALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTC 607
                           .||                   ||:|...|.|:...::|.|.||:.|..|
Frog   653 ---------------FSS-------------------PCLNRGICNNEGAFYSCTCAEGFTGENC 683

  Fly   608 AENLDDCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCETDI-DECATSPCRNGGECVDMVGKFN 670
            .:.:..|:.. |.|||||||:...|.|.|...|.|..|:|:| ..|.::||.|.|.|.:..|.:.
Frog   684 EKEVSPCLSSPCLNGATCIDMGASYSCMCPQAFTGALCDTEIPSPCTSNPCENKGVCREAEGGYL 748

  Fly   671 CICPLGYSGSLCE-EAKENCTPSPCLE-GHCLNTPEGYYCHCPPDRAGKHCE-QLRPLCSQPPCN 732
            |.||.|:||..|| ...::|   ||.. |.|.:  ....|||||...|..|| ::..|    ||:
Frog   749 CDCPAGFSGMHCEHRVSDDC---PCRNGGRCAD--GNSTCHCPPGHFGLLCEYEVTSL----PCS 804

  Fly   733 EG-------------------CFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMS 778
            .|                   |..:..|:..:..:...:.              ||...|:||..
Frog   805 MGSQCPDGGSCMEYGGSYLCVCHTDYILSNHSIPSPCDSD--------------PCLNGGTCESL 855

  Fly   779 DVGTFCKCHVGHTGTFCEH-NLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATG-CY 841
            |....|.|..|..|..||. ....||.:||||||.|.:...::.|.|...:|||.|.....| |.
Frog   856 DDAYTCACPRGFNGRLCEKVKPALCSLSPCRNGGTCKESREEYYCVCPYPFTGKHCETGMRGPCS 920

  Fly   842 AGQCQNGGTCMPGAPDKALQPH------CRCAPGWTGLFC------------------------- 875
            :|.|.|||||.          |      |.|.|.::|..|
Frog   921 SGPCNNGGTCF----------HYLGKYKCDCPPNFSGRHCEKAELDCGAPEQVKYAKMIVTSTLP 975

  Fly   876 ----------------------------------AEAIDQCRGQPCHNGGTCESGAGWFRCVCAQ 906
                                              .|.||:|...|||||.:|:.....|.|.|.:
Frog   976 GGRAEYHCNEGYVLSTPNNTSVCSEEGTWSLPPECEEIDECASHPCHNGASCKDRISHFICECQK 1040

  Fly   907 GFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEILLSDPKSACQNASNTISP 971
            |:||..|....|||..|||:.|.||.|..|.:.||||.|..|..||
Frog  1041 GYSGKYCEQETNECLSQPCKNGGTCQDLPGTFKCICPEGFTGSYCE------------------- 1086

  Fly   972 YTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNL----WCGLPNCYKVDPLSKSSNLSG 1032
                              ||.| .|::..|:|| ..|.||    .|..|.              |
Frog  1087 ------------------TEVD-GCDSSPCQNG-GLCENLAGSYLCVCPR--------------G 1117

  Fly  1033 VCKQHEVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILL 1097
            ....|  | ..:|:.||.:||..||.|
Frog  1118 FFGYH--C-QTVSDMCLLNPCGNRGVC-------------------------------------- 1141

  Fly  1098 ALERVGKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTV---ELTVSSS 1159
                   .:|.:||.|                            |..:||...|:   ||.
Frog  1142 -------VSSADGLMS----------------------------CTCRTGYTGTMCEKELL---- 1167

  Fly  1160 KLNDPQLPVAVGLLGELLSFRQLNGIQRRKELELQHAKLAALTSIVEVKLETARVADGSGHSLLI 1224
                |.|.:::|.:||                             ..|.:......||:||
Frog  1168 ----PPLSLSLGAVGE-----------------------------NSVWVFWTPPEDGTGH---- 1195

  Fly  1225 GVLCGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLDALRHEEE-------KSNNL---QNE 1279
                    ||.||:|          :|....|::.|..::....|.|       :|.|:   ..:
Frog  1196 --------VLDGFAV----------SYTAPDGLSRTDFVERAHTEHELRGLSPGRSYNITIVTVK 1242

  Fly  1280 ENLRR--YTNPLKGSTSSLRAATGMELSLNPAPELAASAASSSALHR-----------SQPLFPP 1331
            .|||.  .:.||. .|:..|........:|...:.:.|.:.|.:.||           ..|..||
Frog  1243 RNLRHNDISRPLY-LTARTRPPNVDRPRINSVMDTSVSVSWSLSPHRHTSIARVRLFLQHPTEPP 1306

  Fly  1332 CDFERELDSSTG------LKQAHKRSSQI 1354
            ...|:|  .|.|      |:...|.|.||
Frog  1307 QQAEQE--PSAGEYIFRDLRPGEKYSVQI 1333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	20/97 (21%)
		DSL	220..282	CDD:279722	18/73 (25%)
		EGF_CA	350..388	CDD:238011	12/37 (32%)
		EGF_CA	490..526	CDD:238011	14/35 (40%)
		EGF_CA	610..645	CDD:238011	14/35 (40%)
		EGF_CA	647..683	CDD:238011	14/36 (39%)
		EGF_CA	798..833	CDD:238011	14/34 (41%)
		EGF_CA	879..913	CDD:238011	15/33 (45%)
		EGF_CA	916..952	CDD:238011	17/35 (49%)
		VWC_out	<993..1053	CDD:214565	16/63 (25%)
sned1	XP_012826283.1	NIDO	99..251	CDD:214712	4/20 (20%)
		EGF_CA	267..303	CDD:238011	9/36 (25%)
		EGF_CA	<314..342	CDD:238011	8/33 (24%)
		EGF_CA	387..418	CDD:238011	8/31 (26%)
		EGF_CA	<427..456	CDD:238011	8/35 (23%)
		EGF	462..492	CDD:278437	8/29 (28%)
		EGF_CA	<503..532	CDD:238011	7/28 (25%)
		EGF_CA	<579..608	CDD:238011	15/90 (17%)
		EGF_CA	<617..646	CDD:238011	12/28 (43%)
		EGF	652..682	CDD:278437	13/73 (18%)
		EGF_CA	690..721	CDD:238011	14/30 (47%)
		EGF_CA	730..761	CDD:238011	12/30 (40%)
		EGF_CA	841..873	CDD:238011	10/45 (22%)
		EGF_CA	881..912	CDD:238011	13/30 (43%)
		EGF_CA	920..951	CDD:238011	12/40 (30%)
		CCP	957..1011	CDD:153056	0/53 (0%)
		EGF_CA	1013..1048	CDD:238011	15/34 (44%)
		EGF_CA	1052..1086	CDD:238011	17/33 (52%)
		EGF_CA	1089..1124	CDD:238011	13/53 (25%)
		fn3	1176..1244	CDD:278470	19/118 (16%)
		fn3	1262..1344	CDD:278470	17/74 (23%)
		FN3	1360..1448	CDD:238020
		MAGP	<1594..1641	CDD:283223
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11681
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010