DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and tnn

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_017949080.2	Gene:	tnn / 100491528	XenbaseID:	XB-GENE-998034	Length:	1109	Species:	Xenopus tropicalis

Alignment Length:	967	Identity:	222/967 - (22%)
Similarity:	323/967 - (33%)	Gaps:	341/967 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 CDCAAGWTGPTCEINI--DECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNECEAPHSA 538
            |.|..||.|..|....  :.|||     .|.|||.:    |:|.|.:.|..|    :|...|...
Frog   152 CQCDEGWEGDDCSTKSCPNNCAG-----NGKCIDGV----CQCAPGYSGPDC----SEKVCPFDC 203

  Fly   539 GIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWG 603
            |                                     ..|.|        :.||  |.|.||:.
Frog   204 G-------------------------------------KYGTC--------EDGS--CKCAEGYT 221

  Fly   604 GVTCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGK 668
            |..|.:.  .|...|....||:    |..|.|:.|:.|..|..  .:|... |...|:|:|
Frog   222 GPACRKK--KCPFDCGEFGTCV----DGTCQCSEGYTGPACRK--KKCPLD-CGEHGKCID---- 273

  Fly   669 FNCICPLGYSGSLCEEAK--ENCTPS-PCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPP 730
            .:|.|..||.|..|:|.|  .:|.|: .|::|.|:
Frog   274 GSCKCSEGYKGVDCKEKKCAVDCGPNGRCVDGQCV------------------------------ 308

  Fly   731 CNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCKCHVGHTGTFC 795
            ||:| |...|.:....:.                    |||||...|...|  |:|..|..||.|
Frog   309 CNDG-FMGSSCSIEIASL--------------------CSGHGKYLMDTGG--CQCDDGWEGTDC 350

  Fly   796 EHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKAL 860
            ..  ..| ||.|.|.|:|:||    .|:|.||:||..||||.  | ...|...|:|:.||
Frog   351 SQ--RSC-PNNCDNNGVCVDG----VCQCFSGYTGLDCSERE--C-PFDCGEHGSCVDGA----- 400

  Fly   861 QPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCR----------I 915
               |:|:.|:|||.|.|  :.|... |...|.|:.|    :|.|.:||.|.||.          |
Frog   401 ---CKCSVGYTGLTCRE--EDCLVN-CGENGRCDGG----QCFCEEGFIGEDCSEVITVQNLHLI 455

  Fly   916 NVNECSPQPCQGGATCIDGIGGYSCIC--PPGRHGLRCEILLSDPKSACQ-NASNTISPYTALNR 977
            :..|.|..........:|    |..:.  |....||:.||.:|..|...| ...|..:.|..|..
Frog   456 SATEDSLSIAWDMLLEVD----YYLLVYYPLDNEGLKKEIQVSVDKDTYQIMGLNPGTKYKVLMY 516

  Fly   978 SQNWLDIALTGRTEDDENCNACVCENG-TSRCTNLWCGLPNCYKVDPLSKSSNLS----GVCKQH 1037
            :                      .:|| ||:...|            |:|:.::|    .|.::.
Frog   517 N----------------------AKNGVTSQPAEL------------LAKTDSISLGTLWVAEET 547

  Fly  1038 EVCVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLTILLALERV 1102
            |                   |...:|                |.| .:||.:..:|.....|
Frog   548 E-------------------DSLEVE----------------WEN-PIVNVDHYKLKYAQQL--- 573

  Fly  1103 GKGASVEGLCSLVRVLLAAQLIKKPASTFGQDPGMLMVLCDLKTGTNDTVEL-TVSSSKLNDPQL 1166
             .||.        |.::.:|         .|||.....:..|:..|:..:.: ||.|.....|.
Frog   574 -NGAE--------REVIVSQ---------SQDPKSRYTITGLQPSTSYQISVQTVRSGLEGKPS- 619

  Fly  1167 PVAVGLLGELLSFRQLNGIQRRKELEL--QHAKLAALTSIVEVKLETARVA--DGSGHSLLIGVL 1227
             .|||:.|       ::|.:.....|:  ..|.|:...|..::.....|.:  ||....:.:|
Frog   620 -TAVGVTG-------IDGPKNLVTTEVGEDTASLSWKGSQADIDKYMLRYSAHDGIAEEISLG-- 674

  Fly  1228 CGVFIVLVGFSVFISLYWKQRLAYRTSSGMNLTPSLDALRHEEEKSNNLQNEENLRRYTNPLKGS 1292
                              |:::   ::|..||||..:.:.|       |..|          ||:
Frog   675 ------------------KEKI---STSLSNLTPGTEYMFH-------LWAE----------KGT 701

  Fly  1293 TSSLRAATGMELSLNPAPELAASAASSSA-LHRSQPLFPPCDFERELDSSTGLKQAHKRSSQILL 1356
            ..|.|.:......::|...|..|.:...| |..:||:.....:...|:.|.|.:|      :|.|
Frog   702 QQSKRTSVTAVTEIDPPKNLQYSKSQPQASLTWNQPIAQIDGYVLVLEDSDGGQQ------EIQL 760

  Fly  1357 HKTQNS----DMRKN---TVGSLDSPRKDFGKRSINCK---SMPPSSGDEGSDVLAT 1403
            ..|.|:    |:.|.   ||..| :.|.|...|.:...   .:.|.:..:..||..|
Frog   761 DSTVNNFELQDLNKGLKYTVYLL-AYRGDRRSRQVTTSFYTDIDPPTNLQSFDVTQT 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011
		EGF_CA	490..526	CDD:238011	11/37 (30%)
		EGF_CA	610..645	CDD:238011	9/34 (26%)
		EGF_CA	647..683	CDD:238011	10/35 (29%)
		EGF_CA	798..833	CDD:238011	15/34 (44%)
		EGF_CA	879..913	CDD:238011	10/33 (30%)
		EGF_CA	916..952	CDD:238011	7/37 (19%)
		VWC_out	<993..1053	CDD:214565	10/64 (16%)
tnn	XP_017949080.2	exchanger_TraA	<124..432	CDD:411343	115/430 (27%)
		fn3	449..513	CDD:394996	15/67 (22%)
		fn3	543..619	CDD:394996	22/132 (17%)
		fn3	630..707	CDD:394996	20/116 (17%)
		fn3	716..788	CDD:394996	21/78 (27%)
		fn3	803..879	CDD:394996	4/14 (29%)
		FReD	895..1105	CDD:238040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910