DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser and dll4

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_002939596.3	Gene:	dll4 / 100489166	XenbaseID:	XB-GENE-480902	Length:	673	Species:	Xenopus tropicalis

Alignment Length:	624	Identity:	215/624 - (34%)
Similarity:	298/624 - (47%)	Gaps:	138/624 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLKEYQTT 137
            |::||.::|::|.|:||:.|..|||..|:||..| :|            .|.|.|::|||.|||.
Frog    14 LLILVKQVSSSGVFQLELHEFINTNGMLVNGKSC-LP------------NCRTFFKICLKHYQTV 65

  Fly   138 EQGASISTG-CSFGNATTKILGGSSFVLS--DPGVGAIVLPFTFRWTKSFTLILQALDMYNTSYP 199
                 :|.| |:||:..|.:||.::|.:.  :.....|.|||.|.|.|:|:||::|... .|...
Frog    66 -----VSPGSCTFGSVITPVLGSNTFSIKGMEGFTNPIKLPFNFTWPKTFSLIIEAFHS-PTDLS 124

  Fly   200 DAERLIEETSYSGVILPSPEW-KTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCRPRDDQFGHY 263
            ..|..|.:.:....:....|| :.:...|...::.:..||.|:..||..:|:..|:||||:||||
Frog   125 QQEIKISQFTIQKPLNVGEEWSRDIQSGGSQIQLKFSYRVVCSENYYGESCSRLCKPRDDRFGHY 189

  Fly   264 ACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECMVYPGCKHGS 328
            .|..:|:..||.||:|..|.|.||..||...:|.|::||||.|||||:|..||||:.:.||:||:
Frog   190 LCEPDGRVSCLKGWKGEYCAEPICLDGCSEQNGYCNKPGECTCRPGWQGRFCNECIPHNGCRHGT 254

  Fly   329 CNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHP 393
            |. ..|:|:||..|||:.||||||:|..|:|||:|.||.||....|.|:|..|.||..||.....
Frog   255 CQ-IQWQCICDEGWGGLFCDQDLNYCTHHKPCKNGATCMNTGQGSYTCSCPPGFSGVNCEDKIRE 318

  Fly   394 CATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGL 458
            |.:.||||||:|                                |.|:         ||
Frog   319 CDSNPCRNGGSC--------------------------------RDLE---------NG------ 336

  Fly   459 VSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGG--FRCECPPEWH 521
                           :.|:|..|:.|..||.::..|...||.:||||.:...|  :.|:||..:.
Frog   337 ---------------YRCECPQGYDGSHCEKSVLNCGNSPCFNGGTCREREVGASYTCQCPLGFT 386

  Fly   522 GDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKE 586
            |..|:..|::|..                                            .||:|..:
Frog   387 GSNCEKKVDKCTR--------------------------------------------NPCLNGGQ 407

  Fly   587 CRNQPGSFACICKEGWGGVTCAENLDDCV-GQCRNGATCIDLVNDYRCACASGFKGRDCETDIDE 650
            |.:...:..|.|:.|:.|.|||.|:|||. ..|.||..|.|.||||.|.|..|::||.|.....|
Frog   408 CFDFGKTQLCRCRPGFTGPTCAINIDDCAKNPCLNGGICTDAVNDYYCDCPPGYRGRTCNVKTIE 472

  Fly   651 CATSPCRNGGECVDMVGKF--NCICPLGYSGSLCEEAKE 687
            |.. ||.|||.|  .:|.:  ||.||.|:.|||||...|
Frog   473 CIL-PCMNGGTC--YIGPYDNNCDCPPGFMGSLCENPIE 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	30/78 (38%)
		DSL	220..282	CDD:279722	24/62 (39%)
		EGF_CA	350..388	CDD:238011	19/37 (51%)
		EGF_CA	490..526	CDD:238011	12/37 (32%)
		EGF_CA	610..645	CDD:238011	18/35 (51%)
		EGF_CA	647..683	CDD:238011	17/37 (46%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
dll4	XP_002939596.3	MNNL	24..86	CDD:400141	30/79 (38%)
		DSL	145..208	CDD:396134	24/62 (39%)
		EGF_CA	275..313	CDD:238011	19/37 (51%)
		EGF_CA	316..351	CDD:238011	16/96 (17%)
		EGF_CA	359..391	CDD:238011	11/31 (35%)
		EGF	397..427	CDD:394967	9/73 (12%)
		EGF_CA	431..466	CDD:238011	18/34 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6086
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010