DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and crb2

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_002937280.2	Gene:	crb2 / 100487355	XenbaseID:	XB-GENE-989701	Length:	1456	Species:	Xenopus tropicalis

Alignment Length:	742	Identity:	198/742 - (26%)
Similarity:	275/742 - (37%)	Gaps:	224/742 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 CDQDLNFCGTHEPCKHGGTCENTAPDKYRCTC-AEGL--SGEQCEIVEHPCATRPCRNGGTCTLK 408
            |.|.|.......||.:||||:.|| ..:.|.| ||.|  :|..|..:...||...|.:..:|
Frog    24 CGQGLAQTCVSSPCLNGGTCQETA-SGFTCLCPAEPLAFTGTTCGDLYDACAIDRCPSTHSC--- 84

  Fly   409 TSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQ-------- 465
                           :|..|.|           |.:...|       |||......|
Frog    85 ---------------QSTPGHP-----------HFQCVCQ-------PGLNCTNECQRNSCPFQN 116

  Fly   466 LQQQLAPD-FTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDV 529
            .|..:..| |.|.|.:|:.|..|...:..|...||::..||:.....|||.|.|.:.|..|:|:|
Frog   117 FQCTVGEDSFMCKCQSGYGGVDCNFEVSPCFQNPCQNNATCLAEGDSFRCVCEPGFTGQECEVNV 181

  Fly   530 NECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKECRNQPGSF 594
            |||                                            |..||.|...|.::...:
Frog   182 NEC--------------------------------------------ASNPCQNEALCVDKVDRY 202

  Fly   595 ACICKEGWGGVTCAENLDDCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCETDIDECATSPCRN 658
            .|.|..|:.|..|..::::|..: |:|..||::.::.|.||||:|:.|.:||.:||||.:.||:|
Frog   203 MCFCVPGFQGHHCEIDINECASRPCQNNGTCMNQLDQYECACANGYTGINCEMEIDECQSVPCQN 267

  Fly   659 GGECVDMVGKFNCICPLGYSGSLCEEAKENCTPSPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLR 723
            |..|.|.:|.|.|.||.||.|..|:...:.|...||..|
Frog   268 GATCRDHIGYFTCDCPAGYDGEQCQHDIDECQSQPCQNG-------------------------- 306

  Fly   724 PLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTF-CKC- 786
                                                             |.| |.::..| |.|
Frog   307 -------------------------------------------------GQC-MDEINRFRCDCS 321

  Fly   787 HVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTC 851
            :.|..|..||..:.||..|||:|.|.|::....:.|.|..|::|..|......|:...|.|||.|
Frog   322 NTGFVGGRCEVEILECDSNPCQNNGTCMERVNGYECLCWKGYSGIHCEIDDNECFEEPCVNGGLC 386

  Fly   852 MPGAPDK--ALQPH-------------CRCAPGWTGLFCAEAIDQCRGQPCHNGGTCESGAGWFR 901
            :..:...  ..:|.             |||..|:||..|:..||:|...||.|||||......|.
Frog   387 LELSNQSYYGTEPEFNKFSYSQAAGYLCRCQQGFTGPNCSVNIDECESWPCLNGGTCTDLINGFL 451

  Fly   902 CVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRH------GLRCEI-LLSDPK 959
            |.||.|::|.||.||::||...||:.||:|.||:..|||||||...      |..|.: |:...:
Frog   452 CNCASGYTGFDCSINIDECKDSPCKNGASCEDGVADYSCICPPAAQDGTVWGGKNCSVMLIGCLE 516

  Fly   960 SACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCYKV--- 1021
            .:||||:..|..||..:.|.                  .|.|:.|   .....|..|..:..
Frog   517 HSCQNAAECIPLYTGQSHSY------------------TCKCQPG---FVGNNCSTPTTFSFLSQ 560

  Fly  1022 ------DPLSKSSNLSGVCKQHEVCVP 1042
                  .|||..|..|.:..:....:|
Frog   561 GYLMYDSPLSNESYQSNMSVRFRTTLP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722
		EGF_CA	350..388	CDD:238011	15/40 (38%)
		EGF_CA	490..526	CDD:238011	11/35 (31%)
		EGF_CA	610..645	CDD:238011	12/35 (34%)
		EGF_CA	647..683	CDD:238011	18/35 (51%)
		EGF_CA	798..833	CDD:238011	12/34 (35%)
		EGF_CA	879..913	CDD:238011	16/33 (48%)
		EGF_CA	916..952	CDD:238011	18/41 (44%)
		VWC_out	<993..1053	CDD:214565	11/59 (19%)
crb2	XP_002937280.2	EGF_CA	<149..178	CDD:238011	10/28 (36%)
		EGF_CA	180..216	CDD:238011	13/79 (16%)
		EGF_CA	218..254	CDD:238011	12/35 (34%)
		EGF_CA	257..292	CDD:238011	18/34 (53%)
		EGF_CA	294..331	CDD:238011	12/112 (11%)
		EGF_CA	336..369	CDD:238011	12/32 (38%)
		EGF_CA	428..463	CDD:238011	16/34 (47%)
		EGF_CA	466..>494	CDD:214542	15/27 (56%)
		Laminin_G_2	582..712	CDD:366983	1/6 (17%)
		EGF_CA	742..771	CDD:238011
		Laminin_G_2	807..921	CDD:366983
		EGF_CA	<961..990	CDD:238011
		Laminin_G_2	1046..1160	CDD:366983
		EGF_CA	1196..1227	CDD:238011
		EGF_CA	1229..1264	CDD:238011
		EGF_CA	1266..1302	CDD:238011
		EGF_CA	1345..1381	CDD:238011
		Insulin_TMD	<1396..1427	CDD:375394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910