DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and notch2

DIOPT Version :9

Sequence 1:NP_001287558.1 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:XP_002939126.3 Gene:notch2 / 100486344 XenbaseID:XB-GENE-6046917 Length:2455 Species:Xenopus tropicalis


Alignment Length:1248 Identity:322/1248 - (25%)
Similarity:456/1248 - (36%) Gaps:386/1248 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 GYC---CGMPAELRATKTIGCS--PCTTAFRLCLKEYQ--TTEQG--------ASISTGCSFGN- 151
            |.|   .|||         ||.  .|..|...||.|.:  |.:.|        |.:...|...| 
 Frog     8 GLCVLLLGMP---------GCDGLQCRGASEPCLNEGKCITNDDGSAYCKCTDAFVGKYCQLQNP 63

  Fly   152 --ATTKILGGSSFVLSD---------PGVG--------AIVLPFTFRWTKSFTLILQALDMYNTS 197
              .|..:.||:..|.||         ||.|        |.|...|.......|..|..|::|:..
 Frog    64 CQETICLNGGTCKVSSDLSKGVCTCAPGFGGENCKQPVANVCSLTQPCMNGGTCHLLTLELYDCI 128

  Fly   198 YPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCT--TFCRPRDDQF 260
            .|...|             ..:.|.:|              .||    :..|.  :.|.|.::| 
 Frog   129 CPFGWR-------------GNDCKFID--------------ACA----SQPCANGSTCIPNENQ- 161

  Fly   261 GHYACGSEGQKLCLNGWQGVNCE--------EAICKAGCDPVHGKCDR-PG--ECECRPGWRGPL 314
              |.|.      |..|:.|:.||        ..:||.|     |.|:. ||  .|:|.||:.|..
 Frog   162 --YTCS------CQAGYTGLKCEVDVNECGPPGMCKNG-----GTCENFPGSYRCQCHPGYTGQR 213

  Fly   315 CN-------------------------ECMVYPG------------CKHGSC-NG-------SAW 334
            |.                         ||...||            |....| ||       :.:
 Frog   214 CESPFIPCSPSPCMNGGTCRQTSEFAYECNCLPGFDGKNCETNIDDCPSHKCQNGGTCVDGVNTY 278

  Fly   335 KCVCDTNWGGILCDQDLNFCGTH-EPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRP 398
            .|.|...|.|..|.:|::.|... ..|::||||.| :...|.|.|..|.||:.|......|||..
 Frog   279 NCRCPPQWTGQFCTEDVDECQLQPNACQNGGTCTN-SNGGYNCVCVNGWSGDDCSQNIDDCATAA 342

  Fly   399 CRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSS-------MRSLDHLRP-EGQAL----- 450
            |.||.||.    :|..:.:.....|:  :|....::.:       |.||....| .|||:     
 Frog   343 CANGSTCI----DRVASFICVCPEGK--IGLLCHKNDACFSNPCHMGSLCDTNPLTGQAICTCPS 401

  Fly   451 --NGSSSPGLVSLGSLQLQQ---------QLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGT 504
              .|::....:...||....         .....|.|:|:.|:|||.||::|:||...||::..|
 Frog   402 GYKGTACTEDIDECSLVNSNPCEHAGKCVNTEGSFYCECSKGFTGPRCEMDINECLSEPCQNDAT 466

  Fly   505 CIDLIGGFR--------------------------------------CECPPEWHGDVCQVDVNE 531
            |:|.||||.                                      |.|||.:.|.|||:|:::
 Frog   467 CLDKIGGFTCLCMPGYKGIHCEIEINECLSNPCVNNGECVDKVNRFVCICPPGFTGSVCQIDIDD 531

  Fly   532 CEA----------PHSAGIAANALLTTTATAII-GSNLSS-----------------------TA 562
            |.:          .|.:|.  :.:..|..|.:: ..|:::                       ..
 Frog   532 CSSTPCQNGAKCVDHPSGY--DCICATGFTGVLCEENINNCEPPPCHYGTCQDGIDSYTCICEPG 594

  Fly   563 LLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQ-CRNGATCID 626
            .:.|:.|......|: .||:|...|.:....:.|.|..|..|..|.:|:|||... |..| .|:|
 Frog   595 YMGAICSDQIDECLS-NPCLNEGRCVDLVNGYQCNCLPGTSGPRCEKNVDDCASNPCTYG-NCVD 657

  Fly   627 LVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTP 691
            .:|.|.|.|:.||.|..|:.||||||::||.|||.||:...:|.||||.|:....|....:.|..
 Frog   658 GINRYDCVCSPGFTGPQCKDDIDECASNPCHNGGTCVNEQNRFRCICPEGFRQPSCFSQVDECVN 722

  Fly   692 SPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEG---------------------- 734
            :||:.|:|.:...||.|.|.|...||.||..:..|...||..|                      
 Frog   723 NPCIHGNCTDDVNGYKCLCQPGWTGKKCEVDKNECLSNPCQNGGTCDNLVNGYRCSCKKGFKGYN 787

  Fly   735 -------CFANVSL--------ATSATTTTTTTTTATTTRKMAKP--------SGL--------- 767
                   |.:|..|        ....|.......|.|..:.:..|        .|:         
 Frog   788 CQIDIDECASNPCLNHGTCRDGINGYTCHCGLPYTGTNCQNILTPCSPEPCHNGGICQESEDFKS 852

  Fly   768 ------------------------PCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCR 808
                                    ||..:|.|:.:..|..|.|..|..|..||:|:::|..|||:
 Frog   853 FSCLCATGWHGQRCTIDIDECITNPCKNYGRCQNTKGGYICHCFEGFNGVNCENNIDDCLSNPCQ 917

  Fly   809 NGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGL 873
            ||..|:||...|:|.|::|:.|.:|.:....|.:..|:|||:|    .|......|:|.||:.|:
 Frog   918 NGASCVDGINTFSCNCLAGFHGDKCQKDVDECASNPCKNGGSC----TDYVNSYTCKCQPGFDGI 978

  Fly   874 FCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGY 938
            .|...||:|....|.||.||..|...|.|.|.|||:|..|...:|||...||..|.||:||:|.|
 Frog   979 HCDNNIDECTDTSCFNGATCVDGINSFTCQCPQGFTGQFCLFEINECGSHPCINGGTCVDGMGTY 1043

  Fly   939 SCICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCEN 1003
            .|.||.|..|..||.|:           :..|.:...||.     |....:||.     .|:|..
 Frog  1044 HCTCPVGYRGKNCEELV-----------DLCSGFPCKNRG-----ICKQVKTEP-----KCICPT 1087

  Fly  1004 GTSRCTNLWCGLP--NCYKVDPLSKSSNLSGVCKQHEVCVPA--------------------LSE 1046
            |   .|.::|.:|  :| :|....:...:..:|:...:|:..                    |.|
 Frog  1088 G---WTGIYCDIPDVSC-EVAASQRGVAVQDLCQHAGICINTGFSHRCQCRQGYIGSYCEGELDE 1148

  Fly  1047 TCLSSPCNVRGDC 1059
             |.|:||.....|
 Frog  1149 -CASNPCQNSATC 1160

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_001287558.1 MNNL 83..161 CDD:284966 20/75 (27%)
DSL 220..282 CDD:279722 13/63 (21%)
EGF_CA 350..388 CDD:238011 14/38 (37%)
EGF_CA 490..526 CDD:238011 18/73 (25%)
EGF_CA 610..645 CDD:238011 15/35 (43%)
EGF_CA 647..683 CDD:238011 19/35 (54%)
EGF_CA 798..833 CDD:238011 15/34 (44%)
EGF_CA 879..913 CDD:238011 16/33 (48%)
EGF_CA 916..952 CDD:238011 17/35 (49%)
VWC_out <993..1053 CDD:214565 14/81 (17%)
notch2XP_002939126.3 EGF_CA 141..176 CDD:238011 12/61 (20%)
EGF_CA 178..215 CDD:238011 12/41 (29%)
EGF_CA 256..292 CDD:238011 8/35 (23%)
EGF_CA 294..331 CDD:238011 14/37 (38%)
EGF_CA 334..369 CDD:238011 11/40 (28%)
EGF_CA 411..450 CDD:238011 9/38 (24%)
EGF_CA 452..488 CDD:238011 12/35 (34%)
EGF_CA 491..526 CDD:238011 6/34 (18%)
EGF_CA 528..564 CDD:238011 6/37 (16%)
EGF_CA 566..600 CDD:238011 2/33 (6%)
EGF_CA 604..639 CDD:238011 9/35 (26%)
EGF_CA 641..676 CDD:238011 15/35 (43%)
EGF_CA 678..713 CDD:238011 19/34 (56%)
EGF_CA 717..751 CDD:238011 12/33 (36%)
EGF_CA 753..789 CDD:238011 4/35 (11%)
EGF_CA 791..827 CDD:238011 6/35 (17%)
EGF_CA 869..905 CDD:238011 9/35 (26%)
EGF_CA 907..943 CDD:238011 15/35 (43%)
EGF_CA 945..980 CDD:238011 12/38 (32%)
EGF_CA 983..1018 CDD:238011 16/34 (47%)
EGF_CA 1022..1057 CDD:238011 17/34 (50%)
EGF_CA 1147..1181 CDD:238011 6/15 (40%)
EGF_CA 1184..1219 CDD:238011
EGF_CA 1221..1261 CDD:238011
EGF_CA 1263..1301 CDD:238011
EGF_CA <1311..1342 CDD:238011
Notch 1430..1456 CDD:395019
Notch 1469..1497 CDD:395019
Notch 1506..1535 CDD:395019
NOD 1541..1595 CDD:399654
NODP 1621..1676 CDD:400155
JMTM_Notch_APP 1661..1742 CDD:425406
PHA03095 <1822..>2032 CDD:222980
ANK repeat 1829..1876 CDD:293786
ANK repeat 1879..1909 CDD:293786
ANK repeat 1911..1976 CDD:293786
ANK repeat 1978..2009 CDD:293786
PTZ00322 1984..>2086 CDD:140343
ANK repeat 2011..2042 CDD:293786
DUF3454 2371..2431 CDD:403221
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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