DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser and notch2

DIOPT Version :10

Sequence 1:NP_524527.3 Gene:Ser / 43275 FlyBaseID:FBgn0004197 Length:1407 Species:Drosophila melanogaster
Sequence 2:XP_002939126.3 Gene:notch2 / 100486344 XenbaseID:XB-GENE-6046917 Length:2455 Species:Xenopus tropicalis


Alignment Length:1248 Identity:322/1248 - (25%)
Similarity:456/1248 - (36%) Gaps:386/1248 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 GYC---CGMPAELRATKTIGCS--PCTTAFRLCLKEYQ--TTEQG--------ASISTGCSFGN- 151
            |.|   .|||         ||.  .|..|...||.|.:  |.:.|        |.:...|...| 
 Frog     8 GLCVLLLGMP---------GCDGLQCRGASEPCLNEGKCITNDDGSAYCKCTDAFVGKYCQLQNP 63

  Fly   152 --ATTKILGGSSFVLSD---------PGVG--------AIVLPFTFRWTKSFTLILQALDMYNTS 197
              .|..:.||:..|.||         ||.|        |.|...|.......|..|..|::|:..
 Frog    64 CQETICLNGGTCKVSSDLSKGVCTCAPGFGGENCKQPVANVCSLTQPCMNGGTCHLLTLELYDCI 128

  Fly   198 YPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCT--TFCRPRDDQF 260
            .|...|             ..:.|.:|              .||    :..|.  :.|.|.::| 
 Frog   129 CPFGWR-------------GNDCKFID--------------ACA----SQPCANGSTCIPNENQ- 161

  Fly   261 GHYACGSEGQKLCLNGWQGVNCE--------EAICKAGCDPVHGKCDR-PG--ECECRPGWRGPL 314
              |.|.      |..|:.|:.||        ..:||.|     |.|:. ||  .|:|.||:.|..
 Frog   162 --YTCS------CQAGYTGLKCEVDVNECGPPGMCKNG-----GTCENFPGSYRCQCHPGYTGQR 213

  Fly   315 CN-------------------------ECMVYPG------------CKHGSC-NG-------SAW 334
            |.                         ||...||            |....| ||       :.:
 Frog   214 CESPFIPCSPSPCMNGGTCRQTSEFAYECNCLPGFDGKNCETNIDDCPSHKCQNGGTCVDGVNTY 278

  Fly   335 KCVCDTNWGGILCDQDLNFCGTH-EPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRP 398
            .|.|...|.|..|.:|::.|... ..|::||||.| :...|.|.|..|.||:.|......|||..
 Frog   279 NCRCPPQWTGQFCTEDVDECQLQPNACQNGGTCTN-SNGGYNCVCVNGWSGDDCSQNIDDCATAA 342

  Fly   399 CRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSS-------MRSLDHLRP-EGQAL----- 450
            |.||.||.    :|..:.:.....|:  :|....::.:       |.||....| .|||:     
 Frog   343 CANGSTCI----DRVASFICVCPEGK--IGLLCHKNDACFSNPCHMGSLCDTNPLTGQAICTCPS 401

  Fly   451 --NGSSSPGLVSLGSLQLQQ---------QLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGT 504
              .|::....:...||....         .....|.|:|:.|:|||.||::|:||...||::..|
 Frog   402 GYKGTACTEDIDECSLVNSNPCEHAGKCVNTEGSFYCECSKGFTGPRCEMDINECLSEPCQNDAT 466

  Fly   505 CIDLIGGFR--------------------------------------CECPPEWHGDVCQVDVNE 531
            |:|.||||.                                      |.|||.:.|.|||:|:::
 Frog   467 CLDKIGGFTCLCMPGYKGIHCEIEINECLSNPCVNNGECVDKVNRFVCICPPGFTGSVCQIDIDD 531

  Fly   532 CEA----------PHSAGIAANALLTTTATAII-GSNLSS-----------------------TA 562
            |.:          .|.:|.  :.:..|..|.:: ..|:::                       ..
 Frog   532 CSSTPCQNGAKCVDHPSGY--DCICATGFTGVLCEENINNCEPPPCHYGTCQDGIDSYTCICEPG 594

  Fly   563 LLAALTSAVASTSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQ-CRNGATCID 626
            .:.|:.|......|: .||:|...|.:....:.|.|..|..|..|.:|:|||... |..| .|:|
 Frog   595 YMGAICSDQIDECLS-NPCLNEGRCVDLVNGYQCNCLPGTSGPRCEKNVDDCASNPCTYG-NCVD 657

  Fly   627 LVNDYRCACASGFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTP 691
            .:|.|.|.|:.||.|..|:.||||||::||.|||.||:...:|.||||.|:....|....:.|..
 Frog   658 GINRYDCVCSPGFTGPQCKDDIDECASNPCHNGGTCVNEQNRFRCICPEGFRQPSCFSQVDECVN 722

  Fly   692 SPCLEGHCLNTPEGYYCHCPPDRAGKHCEQLRPLCSQPPCNEG---------------------- 734
            :||:.|:|.:...||.|.|.|...||.||..:..|...||..|                      
 Frog   723 NPCIHGNCTDDVNGYKCLCQPGWTGKKCEVDKNECLSNPCQNGGTCDNLVNGYRCSCKKGFKGYN 787

  Fly   735 -------CFANVSL--------ATSATTTTTTTTTATTTRKMAKP--------SGL--------- 767
                   |.:|..|        ....|.......|.|..:.:..|        .|:         
 Frog   788 CQIDIDECASNPCLNHGTCRDGINGYTCHCGLPYTGTNCQNILTPCSPEPCHNGGICQESEDFKS 852

  Fly   768 ------------------------PCSGHGSCEMSDVGTFCKCHVGHTGTFCEHNLNECSPNPCR 808
                                    ||..:|.|:.:..|..|.|..|..|..||:|:::|..|||:
 Frog   853 FSCLCATGWHGQRCTIDIDECITNPCKNYGRCQNTKGGYICHCFEGFNGVNCENNIDDCLSNPCQ 917

  Fly   809 NGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGL 873
            ||..|:||...|:|.|::|:.|.:|.:....|.:..|:|||:|    .|......|:|.||:.|:
 Frog   918 NGASCVDGINTFSCNCLAGFHGDKCQKDVDECASNPCKNGGSC----TDYVNSYTCKCQPGFDGI 978

  Fly   874 FCAEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGY 938
            .|...||:|....|.||.||..|...|.|.|.|||:|..|...:|||...||..|.||:||:|.|
 Frog   979 HCDNNIDECTDTSCFNGATCVDGINSFTCQCPQGFTGQFCLFEINECGSHPCINGGTCVDGMGTY 1043

  Fly   939 SCICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCEN 1003
            .|.||.|..|..||.|:           :..|.:...||.     |....:||.     .|:|..
 Frog  1044 HCTCPVGYRGKNCEELV-----------DLCSGFPCKNRG-----ICKQVKTEP-----KCICPT 1087

  Fly  1004 GTSRCTNLWCGLP--NCYKVDPLSKSSNLSGVCKQHEVCVPA--------------------LSE 1046
            |   .|.::|.:|  :| :|....:...:..:|:...:|:..                    |.|
 Frog  1088 G---WTGIYCDIPDVSC-EVAASQRGVAVQDLCQHAGICINTGFSHRCQCRQGYIGSYCEGELDE 1148

  Fly  1047 TCLSSPCNVRGDC 1059
             |.|:||.....|
 Frog  1149 -CASNPCQNSATC 1160

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SerNP_524527.3 MNNL 83..238 CDD:462222 37/169 (22%)
DSL 220..282 CDD:128366 13/63 (21%)
EGF_CA 350..388 CDD:238011 14/38 (37%)
EGF_CA 490..526 CDD:238011 18/73 (25%)
EGF_CA 610..645 CDD:238011 15/35 (43%)
EGF_CA 647..683 CDD:238011 19/35 (54%)
EGF_CA 690..720 CDD:238011 11/29 (38%)
EGF_CA 798..833 CDD:238011 15/34 (44%)
EGF_CA 879..913 CDD:238011 16/33 (48%)
EGF_CA 916..952 CDD:238011 17/35 (49%)
VWC_out <993..1053 CDD:214565 14/81 (17%)
notch2XP_002939126.3 EGF_CA 141..176 CDD:238011 12/61 (20%)
EGF_CA 178..215 CDD:238011 12/41 (29%)
EGF_CA 256..292 CDD:238011 8/35 (23%)
EGF_CA 294..331 CDD:238011 14/37 (38%)
EGF_CA 334..369 CDD:238011 11/40 (28%)
EGF_CA 411..450 CDD:238011 9/38 (24%)
EGF_CA 452..488 CDD:238011 12/35 (34%)
EGF_CA 491..526 CDD:238011 6/34 (18%)
EGF_CA 528..564 CDD:238011 6/37 (16%)
EGF_CA 566..600 CDD:238011 2/33 (6%)
EGF_CA 604..639 CDD:238011 9/35 (26%)
EGF_CA 641..676 CDD:238011 15/35 (43%)
EGF_CA 678..713 CDD:238011 19/34 (56%)
EGF_CA 717..751 CDD:238011 12/33 (36%)
EGF_CA 753..789 CDD:238011 4/35 (11%)
EGF_CA 791..827 CDD:238011 6/35 (17%)
EGF_CA 869..905 CDD:238011 9/35 (26%)
EGF_CA 907..943 CDD:238011 15/35 (43%)
EGF_CA 945..980 CDD:238011 12/38 (32%)
EGF_CA 983..1018 CDD:238011 16/34 (47%)
EGF_CA 1022..1057 CDD:238011 17/34 (50%)
EGF_CA 1147..1181 CDD:238011 6/15 (40%)
EGF_CA 1184..1219 CDD:238011
EGF_CA 1221..1261 CDD:238011
EGF_CA 1263..1301 CDD:238011
EGF_CA <1311..1342 CDD:238011
Notch 1426..1457 CDD:459658
Notch 1464..1498 CDD:459658
Notch 1504..1536 CDD:459658
NOD 1540..1595 CDD:462014
NODP 1620..1676 CDD:462229
JMTM_Notch2 1661..1742 CDD:411986
ANK repeat 1829..1876 CDD:293786
ANKYR <1858..2069 CDD:440430
ANK repeat 1879..1909 CDD:293786
ANK repeat 1911..1976 CDD:293786
ANK repeat 1978..2009 CDD:293786
ANK repeat 2011..2042 CDD:293786
Blue background indicates that the domain is not in the aligned region.

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