DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and dlc

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001096242.1	Gene:	dlc / 100124798	XenbaseID:	XB-GENE-968497	Length:	642	Species:	Xenopus tropicalis

Alignment Length:	632	Identity:	206/632 - (32%)
Similarity:	288/632 - (45%)	Gaps:	141/632 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLK 132
            |.|.:.:.|||   .||.|||:|...|......:.|                 .||:..||:|||
Frog    10 LAATVCLPLVH---PAGVFELKIHSFSTPRPACIAG-----------------RPCSIFFRVCLK 54

  Fly   133 EYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTKSFTLILQALDM---- 193
            ..|..   .|....|:||:|.:.||...|..:||.  ..|.:||.|:|...|:||:::...
Frog    55 HAQPV---VSPDPPCTFGSAVSDILPYESKAVSDS--SPIRVPFHFKWPGIFSLIIESWTTVSAE 114

  Fly   194 YNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTCTTFCRPRDD 258
            .:|..||  .|:...:....:....:|....|:|:.:.:.|...|.|...||..:|:.:||||||
Frog   115 QSTENPD--NLLSRLATRRRLSVGEDWSQDIHLGQQSELRYSYHVSCDEHYYGDSCSDYCRPRDD 177

  Fly   259 QFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECMVYPG 323
            .||||.|..:|.:|||:||:|..|.|.||..||...||.|:.||||:||.||:|.||:||:.|||
Frog   178 NFGHYTCDEQGNRLCLSGWKGEYCAEPICLPGCSESHGFCEIPGECKCRMGWQGQLCDECVRYPG 242

  Fly   324 CKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCE 388
            |:||||: ..|:|:|...|||:.|:||||:|..|.||::|.:|.||....|.|.|..|.:|..||
Frog   243 CQHGSCS-QPWECICQEGWGGLFCNQDLNYCTNHRPCRNGASCINTGQGSYSCNCRAGFTGTNCE 306

  Fly   389 IVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGS 453
            |..:.||:.||:|||:|
Frog   307 IDINECASNPCKNGGSC------------------------------------------------ 323

  Fly   454 SSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCIDLIG--GFRCEC 516
                          ..|..|:.|.|..|:.|..|:|:...|..|||.:|||||:...  |:.|.|
Frog   324 --------------NDLENDYECVCPRGFYGKNCDISAMTCEDGPCFNGGTCIEKSSGVGYICRC 374

  Fly   517 PPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVASTSLAIGPC 581
            |..:||..|:..::.|                       :|                     .||
Frog   375 PLNYHGSNCEKKIDRC-----------------------TN---------------------SPC 395

  Fly   582 INAKECRNQPGSFACICKEGWGGVTCAENLDDCVGQ-CRNGATCIDLVNDYRCACASGFKGRDCE 645
            :|..:|.:...:..|.|:.|:.|..|..|:|||... |.||.||:|.||.|.|:|..|:.|:||.
Frog   396 LNGGQCLDMGRNVLCKCRPGFSGPRCELNIDDCASNPCANGGTCVDAVNSYTCSCTLGYGGKDCT 460

  Fly   646 TDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCEEAKENCTPS 692
            ..:|.|::.||.|||.|........|.||.|:.|:.||....:.||:
Frog   461 LRVDACSSQPCSNGGTCFTHFSGHVCQCPTGFMGTSCEFRVHDPTPA 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	23/77 (30%)
		DSL	220..282	CDD:279722	27/61 (44%)
		EGF_CA	350..388	CDD:238011	16/37 (43%)
		EGF_CA	490..526	CDD:238011	15/37 (41%)
		EGF_CA	610..645	CDD:238011	18/35 (51%)
		EGF_CA	647..683	CDD:238011	13/35 (37%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
dlc	NP_001096242.1	MNNL	22..76	CDD:284966	21/73 (29%)
		DSL	139..201	CDD:279722	27/61 (44%)
		EGF_CA	268..306	CDD:238011	16/37 (43%)
		EGF_CA	308..343	CDD:238011	14/96 (15%)
		EGF_CA	387..422	CDD:238011	10/78 (13%)
		EGF_CA	424..460	CDD:238011	18/35 (51%)
		EGF_CA	463..498	CDD:238011	13/34 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920