DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and dll1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001093689.1	Gene:	dll1 / 100101697	XenbaseID:	XB-GENE-479210	Length:	721	Species:	Xenopus tropicalis

Alignment Length:	631	Identity:	218/631 - (34%)
Similarity:	296/631 - (46%)	Gaps:	129/631 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 CNLIALILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLC 130
            |.|..|:|..::.:||.:|.|||.:.|..|....|.|..|| .|..|   .|:....|.|.||:|
Frog     5 CMLTLLVLFAVLCQISCSGLFELRLQEFLNKKGLLGNMNCC-RPGSL---GTLQRCDCKTFFRIC 65

  Fly   131 LKEYQTTEQGASISTGCSFGNATTKILGGSSFVL-----SDPGV-GAIVLPFTFRWTKSFTLILQ 189
            ||.||:   ..|....|::|:|.|.:||.:|||:     |||.. ..|..||.|.|..:|:||::
Frog    66 LKHYQS---NVSPEPPCTYGSAVTPVLGTNSFVVPESSSSDPTFSNPIRFPFGFTWPGTFSLIIE 127

  Fly   190 AL-----DMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARITYRVRVQCAVTYYNTTC 249
            |:     |..||..|  ||||...:....:....:|....|......:.|..|..|...||...|
Frog   128 AIHADSADDLNTENP--ERLISRLATQRHLTVGEQWSQDLHSSDRTELKYSYRFVCDEHYYGEGC 190

  Fly   250 TTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPL 314
            :.:||||||.|||::||.:|:|||..||:|:.|.|.||..|||..||.||:||||:||.||:|..
Frog   191 SDYCRPRDDAFGHFSCGEKGEKLCNPGWKGLYCTEPICLPGCDEHHGYCDKPGECKCRVGWQGRY 255

  Fly   315 CNECMVYPGCKHGSCNGSAWKCVCDTNWGGILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCA 379
            |:||:.||||.||:|. ..|:|.|...|||:.|:||||:|..|:|||:|.||.||....|.|:|.
Frog   256 CDECIRYPGCLHGTCQ-QPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCR 319

  Fly   380 EGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLR 444
            .|.:|..|||..:.|...||:|||:||
Frog   320 PGYTGSNCEIEINECDANPCKNGGSCT-------------------------------------- 346

  Fly   445 PEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAGWTGPTCEINIDECAGGPCEHGGTCID-L 508
                                    .|...::|.|..|:.|..||::...||.|||.:||.|.| .
Frog   347 ------------------------DLENSYSCSCPPGFYGKNCELSAMTCADGPCFNGGRCSDNP 387

  Fly   509 IGGFRCECPPEWHGDVCQVDVNECEAPHSAGIAANALLTTTATAIIGSNLSSTALLAALTSAVAS 573
            .||:.|.||..:.|..|:..::.|.:
Frog   388 DGGYICFCPVGYSGFNCEKKIDYCSS--------------------------------------- 413

  Fly   574 TSLAIGPCINAKECRNQPGSFACICKEGWGGVTCAENLDDCVG-QCRNGATCIDLVNDYRCACAS 637
                 .||.|...|.:...|:.|.|:||:.|..|.:|||||.. .|:||.||.|.:|||.|.|..
Frog   414 -----NPCANGAHCEDLGNSYICQCQEGFSGRNCDDNLDDCASFPCQNGGTCQDGINDYTCTCPP 473

  Fly   638 GFKGRDCETDIDECATSPCRNGGECVDMVGKFNCICPLGYSGSLCE 683
            |:.|::|...|.:|..:||.||..|.:...::.|.|..||.|:.|:
Frog   474 GYIGKNCSMPITKCEHNPCHNGATCHERNNRYVCQCARGYGGNNCQ 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	29/77 (38%)
		DSL	220..282	CDD:279722	26/61 (43%)
		EGF_CA	350..388	CDD:238011	18/37 (49%)
		EGF_CA	490..526	CDD:238011	15/36 (42%)
		EGF_CA	610..645	CDD:238011	18/35 (51%)
		EGF_CA	647..683	CDD:238011	12/35 (34%)
		EGF_CA	798..833	CDD:238011
		EGF_CA	879..913	CDD:238011
		EGF_CA	916..952	CDD:238011
		VWC_out	<993..1053	CDD:214565
dll1	NP_001093689.1	MNNL	22..94	CDD:369454	29/78 (37%)
		DSL	161..223	CDD:128366	26/61 (43%)
		EGF_CA	290..328	CDD:238011	18/37 (49%)
		EGF_CA	331..366	CDD:238011	13/96 (14%)
		EGF	372..401	CDD:333761	14/28 (50%)
		EGF_CA	408..442	CDD:238011	11/77 (14%)
		EGF_CA	445..480	CDD:238011	18/34 (53%)
		EGF_CA	488..519	CDD:238011	10/30 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010