DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and vwdel

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_001345360.4	Gene:	vwdel / 100006681	ZFINID:	ZDB-GENE-131121-540	Length:	1721	Species:	Danio rerio

Alignment Length:	1210	Identity:	270/1210 - (22%)
Similarity:	380/1210 - (31%)	Gaps:	498/1210 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 QALDMYNTSYPDAERLIEETSYSGVILP-------SPE-----WKTLDHIGRNARITYR-VRVQC 240
            |:...::.|.|:    ::|::|:   .|       ||:     |.|      .:.:|.| .|..|
Zfish   705 QSRQFHSRSSPN----LQESAYN---FPEDHSLWVSPDALVFSWPT------ESGLTEREARRLC 756

  Fly   241 AVTYYNTT-------------------CTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAI 286
            ..|..|:|                   |....:.:|||                .|.|...  |:
Zfish   757 ESTLRNSTVGSGCWSLLGKVIEPAVEMCVVDLQLKDDQ----------------AWVGATV--AL 803

  Fly   287 CKAGCDPVHGKCDRPGECECR----PGWRGPLCNECMVYPGCKHGSCNGSA----WKCVCDTNWG 343
            .:             .|||.|    ..||.. ..:.:|...|. ..|:|:.    |.|.|...:|
Zfish   804 LE-------------NECERRLLEEVKWRKE-NRDVLVSLKCP-SLCSGNGQCTDWGCSCFPGFG 853

  Fly   344 GILCDQDLNFCGTHEPCKHGGTCENTAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLK 408
            ...|.|                                :|.|..||.|       ..|||.|.::
Zfish   854 SFDCSQ--------------------------------ISDETPEITE-------LENGGLCDVQ 879

  Fly   409 TSNRTQAQVYRTSHGRSNMGRPVRRSSSMR-------------SLDHLRPEGQALNGSSS----- 455
            ....:..:|:         |:..::|..::             |||..|....:...||:
Zfish   880 YGVCSSVKVF---------GQGFKKSYKLKCEVVKEKIVDSEWSLDDARLVPASFQSSSALECQI 935

  Fly   456 PGLVSLGSLQ--LQQQLAP----------------DFTCD-CAAGWT------GPTCEIN----- 490
            |...|..:.|  |:.|:..                |.||. |....|      ..||.|:
Zfish   936 PADPSTTAHQPVLRWQIKVSNDGHSFSNAKILTLFDGTCQICTVSSTVICTLKNRTCSIDGVCFG 1000

  Fly   491 -IDECAGGPCEHGGTCIDLIGGFRCEC-----PPEWH----------GD--VCQVDVNECE---- 533
             .|.....||.   ||...:..:....     ||.:|          |:  |.|...::.|
Zfish  1001 EGDHSPNSPCL---TCRPDLSKYSWSIAEKNEPPVFHPGQSTLKAFSGEDFVYQFSASDPEGSAV 1062

  Fly   534 ------APHSAGIAANALLTTTATAIIGSNLSSTAL---LAALTSAVASTSLAIGPCINAKECRN 589
                  .|..|       |.:.|..:|...||||.:   ||......|.|..|:...::..:|:|
Zfish  1063 FFTLRSGPRDA-------LLSPAGLLIWKALSSTPVTLDLAVTDDCNAVTQAAVKVSVDPCDCQN 1120

  Fly   590 ----------QPGS--FACICKEGWGGVTCAENLDDC-VGQCRNGATCIDLVNDYRCACASGFKG 641
                      .|||  :.|:|..|..|:.|..::||| ...|.:| ||:|.:|.:.|.|:.||.|
Zfish  1121 GASCVTNMNFPPGSGEYLCVCPVGLEGLKCETDVDDCRSNPCLSG-TCVDALNSFTCQCSEGFTG 1184

  Fly   642 RDCETDIDECATSPCRNGGECVDMVGKFNC-ICP---LGYSGSLCEE------------------ 684
            ..|:.|||||.:|.|.:|..|.:.||.|.| .||   :| .|..|::
Zfish  1185 VICDEDIDECLSSLCYSGVSCRNTVGSFVCGPCPDQLIG-DGMTCKQKTVDKINEGTHEITLESV 1248

  Fly   685 ------------AKENCTPSPCLEG-HCLN---TPEGYYC-HCPP--DRAGKHCEQLRPLCSQPP 730
                        .|..||..||..| .|..   |..||.| .|||  :..|:.| ..|....|.|
Zfish  1249 VKLNSFKPKLIPGKSPCTSRPCYPGVQCFESTYTSAGYICGPCPPGLNGNGQTC-MSRTANRQTP 1312

  Fly   731 CNE-GCFANV--SLATSATT----------------------------------TTTTTTTATTT 758
            ..| |..::|  ||.|..:|                                  ||.|....::|
Zfish  1313 LKEDGKLSDVTSSLVTPYSTRKSAEFHAEADRSSASSRWSSPVDRRTITNLDRSTTKTKDNQSST 1377

  Fly   759 RKMAKPSGL-----------PCSGHGSCEMSDVGTF----------------------------- 783
            .|.:....|           ||.....|:.:..|:|
Zfish  1378 SKQSHEEELNPKDNRTCVDSPCFSGVVCDDTSSGSFRCRDCPNGYEGNGITCKPTCRYPCGQNME 1442

  Fly   784 --------------------------------------CKCHVGHTGTFCEHNLNECSPNPCRNG 810
                                                  |:|.:|::|..||..:  |.| ||::|
Zfish  1443 CSQPNTCTCKEGYTGYNCHIAVCRPDCKNKGKCVKPSVCECPLGYSGQTCEEAI--CDP-PCQHG 1504

  Fly   811 GICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFC 875
            |.||..:   .|.|..|:.|.||.......:   |:|||.|:  :||.     |:|.|||.|..|
Zfish  1505 GRCLSRN---HCTCPYGYVGPRCETMVCNRH---CENGGECV--SPDV-----CKCKPGWYGPTC 1556

  Fly   876 AEAIDQCRGQPCHNGGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSC 940
            ..|  .|: ..|.|||||....   .|||..||.|..|:|.:  |:| ||:....|   :....|
Zfish  1557 NSA--DCK-PVCLNGGTCLKPN---VCVCPSGFYGSQCQIAL--CNP-PCKNRGQC---MRNNVC 1609

  Fly   941 ICPPGRHGLRCEILLSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGT 1005
            .||.|..|.||:..:.||  .|.|....:.|                         |.|.|.:|
Zfish  1610 SCPEGYTGKRCQKSVCDP--MCLNNGKCVGP-------------------------NTCSCPSG- 1646

  Fly  1006 SRCTNLW----CGLPNCYKVDPLSKSSNLSGVCKQHEVC------------VPALSETCLSSPCN 1054
                  |    |.:|.|     |.|..| .|.|.....|            .|...:|||:.
Zfish  1647 ------WRGGICNIPVC-----LQKCRN-GGECVGPNTCHCPAGWEGWQCQTPICKQTCLNG--- 1696

  Fly  1055 VRGDCRALEPSRRVAPPRLPAKSSCWPNQAVVNENCARLT 1094
              |.|        |.|      :.|...|.....:|...|
Zfish  1697 --GRC--------VFP------NFCHCRQGYTGPSCGTKT 1720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	15/81 (19%)
		EGF_CA	350..388	CDD:238011	2/37 (5%)
		EGF_CA	490..526	CDD:238011	10/58 (17%)
		EGF_CA	610..645	CDD:238011	14/35 (40%)
		EGF_CA	647..683	CDD:238011	17/39 (44%)
		EGF_CA	798..833	CDD:238011	12/34 (35%)
		EGF_CA	879..913	CDD:238011	13/33 (39%)
		EGF_CA	916..952	CDD:238011	11/35 (31%)
		VWC_out	<993..1053	CDD:214565	18/75 (24%)
vwdel	XP_001345360.4	VWD	422..580	CDD:295339
		EGF_CA	1153..1187	CDD:238011	14/34 (41%)
		EGF_CA	1190..1229	CDD:214542	17/39 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910