DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser and sned1

DIOPT Version :9

Sequence 1:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_017212114.1	Gene:	sned1 / 100001751	ZFINID:	ZDB-GENE-100913-1	Length:	1374	Species:	Danio rerio

Alignment Length:	1170	Identity:	288/1170 - (24%)
Similarity:	410/1170 - (35%)	Gaps:	381/1170 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 YYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNCEEAICKAGCDPVHGK--CDRPG---- 302
            |:|.|.||..        |...|.:     |.|..|:     ..:||.:...||  .:.||
Zfish   187 YHNITWTTGM--------HATSGGD-----LAGLGGI-----AAQAGFNAGDGKRYFNIPGSRTD 233

  Fly   303 ---ECECRPGWRGPLCNECMVYPG----------CKHGSCNGSAWKCVCDTNWGGILCDQDLNFC 354
               |.|....         :.|||          .:.|.||.||                  :.|
Zfish   234 DIVEIETTTN---------VGYPGRWVFRIDDSHVQVGGCNDSA------------------SVC 271

  Fly   355 GTHEPCKHGGTCEN---TAPDKYRCTCAEGLSGEQCEIVEHPCATRPCRNGGTCTLKTSNRTQAQ 416
            ....||::||.|.:   |....:.|:|..|.:|.:|:|....|::.||:|||||..|
Zfish   272 ANLRPCRNGGRCIDDCITGNPSFTCSCLAGFTGRRCQIEVDECSSYPCQNGGTCVDK-------- 328

  Fly   417 VYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSPGLVSLGSLQLQQQLAPDFTCDCAAG 481
                                   ::|                               |.|.|..|
Zfish   329 -----------------------INH-------------------------------FICLCPVG 339

  Fly   482 WTGPTCEINIDECAGGPCEHGGTCIDLIGGFRCECPPEWHGDVCQVDVNEC-EAPHSAGIAANAL 545
            :.|.|||.:||||...||.:|..||..:|.|.|:|...:.|.:|:.|:||| ..|...|.....|
Zfish   340 FIGATCETDIDECQETPCLNGAQCIQGVGNFTCKCQAGYTGFLCESDINECMSVPCLNGGVCEDL 404

  Fly   546 L---TTTATAIIGSNLSSTALLAALTSAVASTSLAIGPCINAKE-CR-NQPGSFACICKEGWGGV 605
            :   |.|.||....:...|.|:.|  .|...|...:|...|..: |. ...|:::|.|..|:.|.
Zfish   405 VNNYTCTCTANFTGSACETELVVA--DAANQTESCVGEICNKHQICEYTNSGNYSCTCMPGYYGD 467

  Fly   606 TCAENLDDCVGQCRNGATCIDLVNDYRCACASGFKGRDCETDIDE--CATS-PCRNGGECVDMVG 667
            .|.|   :|  .|:||..|:| ||. .|.|.:||.|..|:.::.:  |:.: ||.:||.|::..|
Zfish   468 NCEE---EC--PCQNGGICVD-VNG-TCDCPTGFTGLYCQFEVTQTPCSNNRPCPDGGPCLEYGG 525

  Fly   668 KFNCICPLGYSGSLCE-----EAKENCTPSPCLE-GHCLNTPEGYYCHCPPDRAGKHCEQLR-PL 725
            .:.|.|..|......:     :.:..|..|||.. |:|......|.|.|.....|||||::| .:
Zfish   526 TYLCTCQTGAEFDHKDFYPYVQPQSACDSSPCQNGGYCYERDGDYICECKHGYRGKHCERVRLSI 590

  Fly   726 CSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHGSCEMSDVGTFCKCHVGH 790
            |:..||..|                                      |||:.......|.|....
Zfish   591 CASSPCRNG--------------------------------------GSCKEEADSYHCVCPYRF 617

  Fly   791 TGTFCE-HNLNECSPNPCRNGGICLDGDGDFTCECMSGWTGKRCSERATGCYAGQCQNGGTCMPG 854
            ||..|| ...:.|:.:||||||.|....|.:.|||...:.|:.| |...|  :.....|..|  |
Zfish   618 TGKHCEVGKPDPCASSPCRNGGTCFHYIGKYKCECSPSFMGRHC-EINRG--SNPALEGLDC--G 677

  Fly   855 APDKALQPHCR-------------CAPGWTGL------FCA-----------EAIDQCRGQPCHN 889
            .|.||.....:             |.||:|.|      .|:           |.|::|..|||.|
Zfish   678 PPVKAKHAEVQYSSTTPGSMALYLCHPGYTPLTRATQIICSSQGSWSQPPVCEEINECLSQPCMN 742

  Fly   890 GGTCESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYSCICPPGRHGLRCEIL 954
            ||||......:.|.|.:||:|..|:.:::||..:||:.|:||.|..|.|.|.|..|..|..||:
Zfish   743 GGTCRDRVASYLCECEEGFTGQRCQTDMDECLSEPCKHGSTCEDQPGSYFCHCQEGYAGQDCEM- 806

  Fly   955 LSDPKSACQNASNTISPYTALNRSQNWLDIALTGRTEDDENCNACVCENGTSRCTNLWCGLPNCY 1019
                                                 :.:.|....|.||         |:...|
Zfish   807 -------------------------------------EQDGCEPNPCLNG---------GICRGY 825

  Fly  1020 KVDPLSKSSNLSGVCKQHEV---CVPALSETCLSSPCNVRGDCRALEPSRRVAPPRLPAKSSCWP 1081
            :.:.|.       |||:..:   | ..|...|:..||..||.||:   .||       ...||..
Zfish   826 RRNHLC-------VCKEGYIGDRC-QTLENPCVLQPCGNRGVCRS---DRR-------GNYSCAC 872

  Fly  1082 NQAVVNENCAR-------LTILLALE-----RVGKGASVEGLCS--------LVRVLLAAQLIKK 1126
            .......:|.|       |.:|...|     |..:....:.|.|        :.||......::|
Zfish   873 RVGHTGRDCERDLLPPSGLNVLRVEENEVELRWDQSDVTQNLISGFAVAFAPVGRVPRKTDFLEK 937

  Fly  1127 PASTF---GQDPGMLMVLCDLKTGTNDTVE---LTVSSSKLNDPQLPVAVGLLGELLSFRQLNGI 1185
            ..||:   |.:||.|..:......:.|..:   ..:.:......||.| |.:....:..|.|..:
Zfish   938 KHSTYVLQGLNPGQLYNISTYSVNSIDKSQPAFALIRTRPRQVDQLEV-VNVSSSQVWLRWLVHV 1001

  Fly  1186 QRRKELELQHAKLAALTSIVEVKLETARVADGSG---------------HSLLIGVLCGVFIVLV 1235
            .|       ||.:    |.|.|.|..   |||||               .:||.|.:..|.:|
Zfish  1002 GR-------HAAI----SQVRVSLVP---ADGSGSRTAVLNSSVTDYTFSTLLPGQMYTVDVV-- 1050

  Fly  1236 GFSVFISLYWKQRLAYRTSSGMNLTPSLDALRHEEEKSNNLQNEENLRRYTNPLKGSTSSLRAAT 1300
                             |.||         ||.|:..|.: ::...|..:|.||.....|:...|
Zfish  1051 -----------------TQSG---------LRPEDLPSTS-KSAGPLHFWTRPLPPQNLSISHIT 1088

Fly 1301 1300
Zfish 1089 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser	NP_001287558.1	MNNL	83..161	CDD:284966
		DSL	220..282	CDD:279722	10/37 (27%)
		EGF_CA	350..388	CDD:238011	11/40 (28%)
		EGF_CA	490..526	CDD:238011	14/35 (40%)
		EGF_CA	610..645	CDD:238011	13/34 (38%)
		EGF_CA	647..683	CDD:238011	10/38 (26%)
		EGF_CA	798..833	CDD:238011	13/34 (38%)
		EGF_CA	879..913	CDD:238011	15/33 (45%)
		EGF_CA	916..952	CDD:238011	14/35 (40%)
		VWC_out	<993..1053	CDD:214565	13/62 (21%)
sned1	XP_017212114.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010