DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5909 and CFB

DIOPT Version :10

Sequence 1:NP_651544.1 Gene:CG5909 / 43274 FlyBaseID:FBgn0039495 Length:381 Species:Drosophila melanogaster
Sequence 2:NP_001701.2 Gene:CFB / 629 HGNCID:1037 Length:764 Species:Homo sapiens


Alignment Length:367 Identity:99/367 - (26%)
Similarity:147/367 - (40%) Gaps:122/367 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 APPQSNQESQRKVVRSEGGNLNRYDRQGLQLLNSVTNCG-----NKGNPKVSGGKTARPGDF--- 141
            |..:.|::...||...|  ||.....|.:....|::.||     .||.            |:   
Human   443 ASKKDNEQHVFKVKDME--NLEDVFYQMIDESQSLSLCGMVWEHRKGT------------DYHKQ 493

  Fly   142 PWVALLKYKINDPRPFR----CGGSLISERHILTAAHC--IIDQPEVIAVRLG--EHDLESEEDC 198
            ||.|    ||:..||.:    |.|:::||..:||||||  :.|:...|.|.:|  :.|||     
Human   494 PWQA----KISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLE----- 549

  Fly   199 HYLGGTNRVCIPPYEEYGIEQIRVHPNY-VHGK--------ISHDVAIIKLDRVVKEKSHIKPVC 254
                              ||.:..|||| ::||        ..:|||:|||...:|....|:|:|
Human   550 ------------------IEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPIC 596

  Fly   255 LP----------------IDQKSQEL----DFDQSFFVAGWGGTEKETVATKLQQALITRKSLNE 299
            ||                ..|:.:||    |. ::.||     :|:|...|:.:..:........
Human   597 LPCTEGTTRALRLPPTTTCQQQKEELLPAQDI-KALFV-----SEEEKKLTRKEVYIKNGDKKGS 655

  Fly   300 CR---QY---YNK----GEVSDNHICATGTGIK-----HTCQGDSGGPVFFKHRFKNTYRVVQYG 349
            |.   ||   |:|    .||.......|| |:.     :||:||||||:....|    .|.:|.|
Human   656 CERDAQYAPGYDKVKDISEVVTPRFLCTG-GVSPYADPNTCRGDSGGPLIVHKR----SRFIQVG 715

  Fly   350 VVSFGGRLCGQNQP----------GVFASVIDMLPWITQNLQ 381
            |:|:|.....:||.          ....::..:|||:.:.||
Human   716 VISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQ 757

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5909NP_651544.1 CLIP 25..82 CDD:197829
Tryp_SPc 132..379 CDD:238113 84/311 (27%)
CFBNP_001701.2 CCP <55..83 CDD:214478
CCP 103..158 CDD:153056
CCP 165..219 CDD:153056
vWA_complement_factors 269..466 CDD:238747 7/24 (29%)
Tryp_SPc 488..755 CDD:238113 84/316 (27%)
Blue background indicates that the domain is not in the aligned region.

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