DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5909 and F10

DIOPT Version :9

Sequence 1:	NP_651544.1	Gene:	CG5909 / 43274	FlyBaseID:	FBgn0039495	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	402	Identity:	107/402 - (26%)
Similarity:	176/402 - (43%)	Gaps:	69/402 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CVT-PAQAAGQC--------------IRYQECP-FVQKILGIYGRNIPRKIHNQISEMQC---RS 70
            |.| |.|..|:|              ...:.|. |.:|:..:...:..:..|.:.:.:.|   |.
Human    90 CETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARG 154

  Fly    71 TTNTRDFHLCCPNEAPP---QSNQESQRKVVR--SEGGNL------NRYDRQGL-------QLLN 117
            .|...:...|.|....|   |:.:..:|.|.:  |..|..      ..||...|       .||:
Human   155 YTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLD 219

  Fly   118 ---SVTNCGNKGNPKVSGGKTARPGDFPWVALLKYKINDPRPFRCGGSLISERHILTAAHCIIDQ 179
               :....|:....::.||:..:.|:.||.|||   ||:.....|||:::||.:|||||||:. |
Human   220 FNQTQPERGDNNLTRIVGGQECKDGECPWQALL---INEENEGFCGGTILSEFYILTAAHCLY-Q 280

  Fly   180 PEVIAVRLGEHDLESEEDCHYLGGTNRVCIPPYEEYGIEQIRVHPNYVHGKISHDVAIIKLDRVV 244
            .:...||:|:.:.|.||     ||.        ..:.:|.:..|..:.......|:|:::|...:
Human   281 AKRFKVRVGDRNTEQEE-----GGE--------AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPI 332

  Fly   245 KEKSHIKPVCLP-IDQKSQELDFDQSFFVAGWGGT-EKETVATKLQQALITRKSLNECRQYYNKG 307
            ..:.::.|.||| .|.....|...::..|:|:|.| ||...:|:|:...:.....|.|: ..:..
Human   333 TFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCK-LSSSF 396

  Fly   308 EVSDNHICA-TGTGIKHTCQGDSGGPVFFKH--RFKNTYRVVQYGVVSFGGRLCGQNQPGVFASV 369
            .::.|..|| ..|..:..||||||||    |  |||:||.|.  |:||:|.....:.:.|::..|
Human   397 IITQNMFCAGYDTKQEDACQGDSGGP----HVTRFKDTYFVT--GIVSWGEGCARKGKYGIYTKV 455

  Fly   370 IDMLPWITQNLQ 381
            ...|.||.::::
Human   456 TAFLKWIDRSMK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5909	NP_651544.1	CLIP	25..82	CDD:197829	14/75 (19%)
		Tryp_SPc	129..376	CDD:214473	78/251 (31%)
		Tryp_SPc	132..379	CDD:238113	80/251 (32%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011	6/31 (19%)
		FXa_inhibition	129..164	CDD:317114	4/34 (12%)
		O-glycosylated at one site	183..203		3/19 (16%)
		Tryp_SPc	235..464	CDD:238113	80/252 (32%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D402896at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920