DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grass and PRSS22

DIOPT Version :9

Sequence 1:	NP_651543.1	Gene:	grass / 43273	FlyBaseID:	FBgn0039494	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_071402.1	Gene:	PRSS22 / 64063	HGNCID:	14368	Length:	317	Species:	Homo sapiens

Alignment Length:	264	Identity:	74/264 - (28%)
Similarity:	125/264 - (47%)	Gaps:	40/264 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 RVSNGYEVKLSSRPWMALLRYQQFGESRFLCGGAMISERYILTAAHCVHGLQND--LYEIRLGEH 180
            ||..|.:...|..||  ::..|:.|...  |.|::::.|:::|||||.....|.  |:.:.||..
Human    49 RVVGGEDSTDSEWPW--IVSIQKNGTHH--CAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAW 109

  Fly   181 RISTEEDCRQQGRKKKCAPPVVNVG-IEKHLIHEKYDARHIMHDIALLKLNRSVPFQKHIKPICL 244
            ::.......|:          |.|. :|.|.::...:.  ...||||::|.||:.|.:.:.||||
Human   110 QLGNPGSRSQK----------VGVAWVEPHPVYSWKEG--ACADIALVRLERSIQFSERVLPICL 162

  Fly   245 PITDELKEKAEQISTYFVTGWGTTENG---SSSDVLLQANVPLQPRSACSQAYRRAV---PLSQ- 302
            |   :........:..:::|||:.::|   .....|.:..||:.....||..|.|..   |:::
Human   163 P---DASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITED 224

  Fly   303 -LCVG--GGDLQDSCKGDSGGPLQAPAQYLGEYAPKMVEFGIVSQGVVTCGQISLPGLYTNVGEY 364
             ||.|  .|: :|:|.|||||||.  .|..|.:    :..||:|.| ..|.:.:.||:|.::..:
Human   225 MLCAGYLEGE-RDACLGDSGGPLM--CQVDGAW----LLAGIISWG-EGCAERNRPGVYISLSAH 281

  Fly   365 VQWI 368
            ..|:
Human   282 RSWV 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grass	NP_651543.1	CLIP	32..90	CDD:197829
grass	NP_651543.1	Tryp_SPc	121..371	CDD:238113	72/261 (28%)
PRSS22	NP_071402.1	Tryp_SPc	50..288	CDD:238113	73/263 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910