DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6051 and ZFYVE16

DIOPT Version :9

Sequence 1:	NP_001097943.1	Gene:	CG6051 / 43271	FlyBaseID:	FBgn0039492	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	NP_001098721.2	Gene:	ZFYVE16 / 9765	HGNCID:	20756	Length:	1539	Species:	Homo sapiens

Alignment Length:	830	Identity:	167/830 - (20%)
Similarity:	280/830 - (33%)	Gaps:	266/830 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 DQLSEMF-----RPFRTILIKIRDLLRNLNNQELYQLEKLLCTNEDINTKVPLG---SSSIEAP- 317
            |::..::     :|...::..:.:|:...|::|  .::|||..:...|....:|   ||..:.|
Human   112 DEIQPLYMGRCSKPICDLISDMGNLVHATNSEE--DIKKLLPDDFKSNADSLIGLDLSSVSDTPC 174

  Fly   318 --SPEHSSHPTTSSSQNNNNSSNNNHSSSS--------TNTTSTTTTTAGTTN-----THRTVER 367
              |.:|.| .|....||:.:|...|.....        ..|.|.:...:||.|     ....:|.
Human   175 VSSTDHDS-DTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLES 238

  Fly   368 LVDQRNNNHNSNSNSS-----------------------TNPTVEAATLRSPSMLSLSA-TSTPT 408
            :||...::..:..:|.                       ....|:.|.:.:...|.... ||..|
Human   239 IVDFNMSSALTRQSSKMFHAKDKLQHKSQPCGLLKDVGLVKEEVDVAVITAAECLKEEGKTSALT 303

  Fly   409 ASPAPSPTPSHSIASTSSAATSSTNPPADWSDGDDE-------DEDDDDIDVDEEDI--ESSD-- 462
            .|   .|.......:.|::...:...| |:|..:|:       .||...:|:.:.|:  :||.
Human   304 CS---LPKNEDLCLNDSNSRDENFKLP-DFSFQEDKTVIKQSAQEDSKSLDLKDNDVIQDSSSAL 364

  Fly   463 --DGTDEEQLLKDIVSADCASGYLIPNTNLGNLLQPQEVPLTDNFVASEDDEYGTAEQQGHQGLE 525
              ...|....|..:.::....|.||.:...|:.|...|                      |:...
Human   365 HVSSKDVPSSLSCLPASGSMCGSLIESKARGDFLPQHE----------------------HKDNI 407

  Fly   526 ED-----EPSTSAAMLAATRTLQRLRLPSSDNEPLAEPTTIKASEEHMQQPSGRHRDSHSHRHHQ 585
            :|     |...::.:|.              .||..|...:|
Human   408 QDAVTIHEEIQNSVVLG--------------GEPFKENDLLK----------------------- 435

  Fly   586 RHHHHHHHRHPHQHQHRQPHPHRTTRSGRKRCS-------LEAADPERIQPD----REQNLASGD 639
                                        :::|.       :|..:..:|.||    |.::|..||
Human   436 ----------------------------QEKCKSILLQSLIEGMEDRKIDPDQTVIRAESLDGGD 472

  Fly   640 TSAASSLSDDVSLAMRNTTARLKFKSTENLLHRLFVCIAGVADQLQTN--FASDLRQILRSVFLM 702
            ||:....|.:   .:..|...   :|::        |..|..:...:|  ...||
Human   473 TSSTVVESQE---GLSGTHVP---ESSD--------CCEGFINTFSSNDMDGQDL---------- 513

  Fly   703 NMSTAQEEIDIPEKTK------ESELFEF-----------RASENDVIQESAGSNQ-SIYSAEEV 749
                  :..:|.|..|      ::||..|           ::.|.:|....:..|| .:...::.
Human   514 ------DYFNIDEGAKSGPLISDAELDAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDG 572

  Fly   750 NPELDNV-FSAGGGNQATGQRHSAG---ASMQRNNTIDLASQPGEGS--PSGATTATSRSHVTRS 808
            |  ::|: |:|..|  |.|:.|...   ..:.:.|||:.....||.|  |......||:|.:|..
Human   573 N--INNIYFNAEAG--AIGESHGINIICEIVDKQNTIENGLSLGEKSTIPVQQGLPTSKSEITNQ 633

  Fly   809 RSLGDQEAASSATSSTAQLRQLEQQQQQQQLQIQLQRQRNNSVGSNTPSSASSTSSSSEQNSPVS 873
            .|:.|..:.|...:...||..|..:.:..:   .|.:       .:.|.:..|..|:::...|::
Human   634 LSVSDINSQSVGGARPKQLFSLPSRTRSSK---DLNK-------PDVPDTIESEPSTADTVVPIT 688

  Fly   874 ARSGSRR-----------RLQSN----------NETQMPSSATSTSATL--SPPAWIPDGKAPRC 915
            ....|..           .::||          ||..:|.:.......|  ..|.|:||.:||.|
Human   689 CAIDSTADPQVSFNSNYIDIESNSEGGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNC 753

  Fly   916 MACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCY 965
            |.||..||..:||||||.||.||||||.|....| :| |.|..|||..||
Human   754 MNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKL-QY-LEKEARVCVVCY 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6051	NP_001097943.1	FYVE_LST2	902..966	CDD:277270	36/64 (56%)
ZFYVE16	NP_001098721.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	469..491		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..678		7/47 (15%)
		FYVE_endofin	738..804	CDD:277268	36/66 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	816..850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..907
		DUF3480	1167..1515	CDD:371829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149921
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840