DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6051 and RUFY1

DIOPT Version :9

Sequence 1:	NP_001097943.1	Gene:	CG6051 / 43271	FlyBaseID:	FBgn0039492	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	NP_079434.3	Gene:	RUFY1 / 80230	HGNCID:	19760	Length:	708	Species:	Homo sapiens

Alignment Length:	394	Identity:	94/394 - (23%)
Similarity:	148/394 - (37%)	Gaps:	93/394 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 CSLEAADPERIQPDREQNLASGDTSAASSLSDDVSLAMRNTTARLK-FKSTENLLHRLFVCIAGV 680
            |||:    |..|..||||....:.|..|     |.:..::|...|: :|.|...|..::
Human   351 CSLQ----EEQQQLREQNELIRERSEKS-----VEITKQDTKVELETYKQTRQGLDEMY------ 400

  Fly   681 ADQLQTNFASDLRQILRSVFLMNMSTAQE-EIDIPEKTKESELFEFRASENDVIQES---AGSNQ 741
                     ||:.:.|:....:.:...:| |:.|..|| |.|: ..:..|.|..::.   ....|
Human   401 ---------SDVWKQLKEEKKVRLELEKELELQIGMKT-EMEI-AMKLLEKDTHEKQDTLVALRQ 454

  Fly   742 SIYSAEEVNPELDNVFSAGGGNQATGQRHSAGASMQRNNTIDLAS--------QPGEGSPSGATT 798
            .:...:.:|  |.....|.....:..|::.|..|.:......::|        |..|.:..|
Human   455 QLEEVKAIN--LQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQG--- 514

  Fly   799 ATSRSHVTRSRSLGDQEAASSATSSTAQLRQLEQQ------------QQQQQLQIQLQRQRNNS- 850
            |..|||..:      ||......:...||.||.:|            :|:|.||.:||.:::.|
Human   515 AEERSHKLQ------QELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSS 573

  Fly   851 ---------------VGSNTPSSASSTSSSSEQNSPVSAR----SGSRRRLQSNNETQMPSSATS 896
                           :.......|.......||...:...    |.|:.:::...|
Human   574 LLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKE--------- 629

  Fly   897 TSATLSPPAWIPDGKAPRCMACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVC 961
            .:..|...||:.|.:|..|..|:..|:..||:|||||||.:||..||:....||.|  .|.||||
Human   630 VNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSY--PKPVRVC 692

  Fly   962 RDCY 965
            ..|:
Human   693 DSCH 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6051	NP_001097943.1	FYVE_LST2	902..966	CDD:277270	29/64 (45%)
RUFY1	NP_079434.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57
		RUN	147..270	CDD:280855
		DUF4201	451..612	CDD:290581	32/171 (19%)
		AAA_23	<486..601	CDD:290211	24/123 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..522		8/31 (26%)
		Interaction with RAB4. /evidence=ECO:0000250	615..625		2/9 (22%)
		FYVE_RUFY1	634..704	CDD:277297	30/65 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149898
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840