Protein Alignment CG6051 and zfyve28

DIOPT Version :9

• Sequence 1: NP_001097943.1
• Gene: CG6051 / 43271
• FlyBaseID: FBgn0039492
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: NP_001071191.1
• Gene: zfyve28 / 777615
• ZFINID: ZDB-GENE-061103-208
• Length: 969
• Species: Danio rerio
• Alignment Length: 1184
• Identity: 360/1184 - (30%)
• Similarity: 487/1184 - (41%)
• Gaps: 427/1184 - (36%)

  Fly     1 MDTFKRWLNKPKADDKSLLARFFHADRSLTAVASELDSFDGRAEPDRCTRLVSRLRQNQDKVLAI 65
            |:.|::||.|||..|..|||:|::||..|..||:||||.|||.:|.|||.||::.|..||.||.|
Zfish     2 MNRFRKWLYKPKRSDPQLLAQFYYADEELNQVATELDSLDGRKDPQRCTLLVNQFRSCQDNVLNI 66

  Fly    66 TNLIMEELLGEDRDPRAFRAKFPEEVLQENLAGQLWFGAECLAAGSSIMNRETESKEMRPLAQAV 130
            .|.||:|.:.|:|..|.|..|||||:..:|||||||||||||||||.|||||.||..|||||:.:
Zfish    67 INQIMDECIPEERANRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNREIESMAMRPLAKDL 131

  Fly   131 TKSLGNVRVLLRDQCLKNNVPNSKTLHLDLNDSTTEQLYESLKIFDRLFAEFELSYVSAMVQVKS 195
            |:||..||.:.|||.|:           ||| ..||::.|:|:.||.||||||||||||||.|||
Zfish   132 TRSLEEVRNITRDQALR-----------DLN-HYTERIKEALRHFDGLFAEFELSYVSAMVPVKS 184

  Fly   196 RHEYEMQQWIGVLFSETLQRALKIGLLDQEMVDAFDPGLMFSIPRLAIVAGLVVYAKGPLNMDMP 260
            ..||.:||.:.|||.||::||||:..|.|:|:|.::|.|||:|||||||.|||:|::||||:|..
Zfish   185 PKEYYIQQEVIVLFCETVERALKLEYLTQDMIDDYEPALMFTIPRLAIVCGLVIYSEGPLNLDRK 249

  Fly   261 GDQLSEMFRPFRTILIKIRDLLRNLNNQELYQLEKLLCTNEDINTKVPLGSSSIEAPSPEHSSHP 325
            .:.:||:||||||:|.||||||:.|..:||..||:.||.::|                   ...|
Zfish   250 PEDMSELFRPFRTLLRKIRDLLQTLTEEELMTLERSLCISQD-------------------GEFP 295

  Fly   326 TTSSSQNNNNSSNNNHSSSSTNTTSTTTTTAGTTNTHRTVERLVD----------------QRNN 374
            |:|:          |..|:||...|.|.    .....:.||.:||                ::..
Zfish   296 TSST----------NDPSASTGPDSQTE----ELEKEKGVEEVVDLTLFVTQEDSVWKEEEEKQV 346

  Fly   375 NHNSNSNSSTNPTVEAATLRS-------------------PSMLSLSATSTPTASPAPSPTPSHS 420
            ...|:|.|.....::|....|                   ..|.:|.:..:...|||..|.|.:.
Zfish   347 LPESSSESEEEEPIDADLACSMQYDEEEIEQLNMMVHQVGDEMSTLLSPPSQNQSPAHRPRPYNG 411

  Fly   421 IASTSSAATSSTNPPADWSDGDDEDEDDDDIDVDEEDIESSDDGTDEE----QL------LKDIV 475
            .:...|:|||||......:.|   ...|||.....:|:||   |...|    ||      |:...
Zfish   412 SSLEGSSATSSTQASPRRAPG---SYHDDDRVFFMDDLES---GLSSELCRGQLPLPTVCLRSPE 470

  Fly   476 SADCASGYLI-----PNTNLG---NLLQPQE-VPLTDNFVASEDDEYGTAEQQGHQGLEEDEPST 531
            .:.| :|:|.     ..||||   .|.|..| |..:|..|            .|.:|| :||.|.
Zfish   471 GSSC-NGWLTVCQSSDATNLGCQRKLSQSTESVGNSDRMV------------NGWEGL-QDEDSV 521

  Fly   532 SAAMLAATRT-----------------LQRLR--LPSSDNEP--------LAEPTTIKA------ 563
            ..|...|.||                 |..|.  ||.|.:.|        :|....:.:
Zfish   522 QTAEEIANRTGGMKLSATVIFNPHSPSLSDLAVVLPQSADAPEGGEGGALVATQCLLNSCVCCAG 586

  Fly   564 ----SEEHMQQPSGRHRDSHSHRHH------------------QRHHH----------HHHHRHP 596
                :.|...:|:||.......:|.                  :.:.|          |..|..|
Zfish   587 GCVDNHEDAMEPAGRSMALGFEKHKLTITSSVIQSAVAAGSPGKGNGHLPLTLPPSQGHLTHSVP 651

  Fly   597 H---QHQHRQP--------HP-----------------------------------HRTTRSGRK 615
            :   |:|.|:.        :|                                   |..:..||.
Zfish   652 NCSVQNQAREDEGSQDGIHYPCCEKCSPGVLLAQDRGSGHEGGPSCTLQDTGCQTQHNASVKGRS 716

  Fly   616 RC-SLEAADPER--IQPDREQNLASGDTS-------------------------AASSLSDDV-- 650
            .| ..::.|..|  ....:|..|:|..:|                         .:|.:|:|:
Zfish   717 ECFGKQSKDDNRKINSSSQESPLSSVPSSDIDGVSVTTCSLSSSYAPSPVSSLTTSSDMSEDLDH 781

  Fly   651 ----------SLAMRNTTARLKFKSTENLLHRLFVCIAGVADQLQTNFASDLRQILRSVFLMNMS 705
                      .||..| ..|.:|.|:.:|:|||||||:|||||||||:|||||.||::
Zfish   782 QEIQVALQAAKLAAHN-KIRSRFHSSSDLIHRLFVCISGVADQLQTNYASDLRSILKT------- 838

  Fly   706 TAQEEIDIPEKTKESELFEFRASENDVIQESAGSNQSIYSAEEVNPELDNVFSAGGGNQATGQRH 770
                            |||..|::.|     .|.|:
Zfish   839 ----------------LFEVMATKTD-----QGDNE----------------------------- 853

  Fly   771 SAGASMQRNNTIDLASQPGEGSPSGATTATSRSHVTRSRSLGDQEAASSATSSTAQLRQLEQQQQ 835
                            :|.:|...|       |.|....:|..:..:||..::.|:..|.|
Zfish   854 ----------------KPKKGPCLG-------SAVLEDCALCQETISSSELAAKAREGQFE---- 891

  Fly   836 QQQLQIQLQRQRNNSVGSNTPSSASSTSSSSEQNSPVSARSGSRRRLQSNNETQMPSSATSTSAT 900
                                                                             
Zfish   892 ----------------------------------------------------------------- 891

  Fly   901 LSPPAWIPDGKAPRCMACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCY 965
             .||.|:||.....|:||:.|||..||:||||:||.:||..||:.|||||:||..|.||||..||
Zfish   892 -DPPEWVPDEACNSCIACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQMKPVRVCTHCY 955

  Fly   966 VREV------RSGM 973
            :..|      |:|:
Zfish   956 MFHVTPFYSDRTGI 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6051	NP_001097943.1	FYVE_LST2	902..966	CDD:277270	36/63 (57%)
zfyve28	NP_001071191.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..323		11/65 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..360		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..437		13/49 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	715..777		9/61 (15%)
		FYVE_LST2	892..956	CDD:277270	36/63 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584058
Domainoid	1	1.000	400	1.000	Domainoid score	I699
eggNOG	1	0.900	-	-		E1_KOG1819
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1348
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D215217at33208
OrthoFinder	1	1.000	-	-		FOG0005719
OrthoInspector	1	1.000	-	-		oto39214
orthoMCL	1	0.900	-	-		OOG6_107592
Panther	1	1.100	-	-	LDO	PTHR46465
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2108
SonicParanoid	1	1.000	-	-		X4713
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.880