DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6051 and ZFYVE28

DIOPT Version :9

Sequence 1:NP_001097943.1 Gene:CG6051 / 43271 FlyBaseID:FBgn0039492 Length:989 Species:Drosophila melanogaster
Sequence 2:XP_006713963.1 Gene:ZFYVE28 / 57732 HGNCID:29334 Length:1044 Species:Homo sapiens


Alignment Length:1112 Identity:324/1112 - (29%)
Similarity:439/1112 - (39%) Gaps:385/1112 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDTFKRWLNKPKADDKSLLARFFHADRSLTAVASELDSFDGRAEPDRCTRLVSRLRQNQDKVLAI 65
            |:.|::||.|||..|..|||||::||..|..||:||||.|||.:|.|||.|||:.|..||.||.|
Human     2 MNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQDNVLNI 66

  Fly    66 TNLIMEELLGEDRDPRAFRAKFPEEVLQENLAGQLWFGAECLAAGSSIMNRETESKEMRPLAQAV 130
            .|.||:|.:.:||.||.|..|||||:..:|||||||||||||||||.|||||.||..|||||:.:
Human    67 INQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKEL 131

  Fly   131 TKSLGNVRVLLRDQCLKNNVPNSKTLHLDLNDSTTEQLYESLKIFDRLFAEFELSYVSAMVQVKS 195
            |:||.:||..||||.|:           ||| :.||::.|:|:.||.||||||||||||||.|||
Human   132 TRSLEDVRGALRDQALR-----------DLN-TYTEKMREALRHFDVLFAEFELSYVSAMVPVKS 184

  Fly   196 RHEYEMQQWIGVLFSETLQRALKIGLLDQEMVDAFDPGLMFSIPRLAIVAGLVVYAKGPLNMDMP 260
            ..||.:||.:.|||.||::|||..|.|.|:|:|.::|.|||||||||||.||||||.||||:|..
Human   185 PREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRK 249

  Fly   261 GDQLSEMFRPFRTILIKIRDLLRNLNNQELYQLEKLLCTNEDINTKV------PLG-SSSIEAPS 318
            .:.:||:||||.|:|.||||||:.|..:||:.||:.||.::|:...:      |.. :.::.||.
Human   250 VEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPL 314

  Fly   319 PEHSSHPTTSSSQNNNNSSNNNHSSSSTNTTSTTTTTAGTTNTHRTVERLVDQRNNNHNSNSNSS 383
            |........:...:...:.:..:........|            |.|.|..|             
Human   315 PPEGPLSAKAKDPDAELACSMQYDDQELEQLS------------RMVHRAGD------------- 354

  Fly   384 TNPTVEAATLRSPSMLSLSATSTPTA--SPAPSPTPSH-----------------SIASTSSAAT 429
                 |.::|.||.:...|....|.|  ||....:|..                 .:..|:.|..
Human   355 -----EMSSLLSPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALA 414

  Fly   430 SSTNPP-------ADWSDGDDEDE-------------DDDDIDVDEEDIESSDDGTDEEQLLKDI 474
            ...:|.       :.|:|..::.:             .:.:.|:...::|:  :|||... |...
Human   415 RPESPAGPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEA--EGTDGAS-LAGT 476

  Fly   475 VSADCASGYLIPNTNLGNLLQPQEVPLTDNFVASEDDEYGTAEQQGHQGLEEDEPSTSAAMLAAT 539
            .|..|....|                ..|.:....||. .|||...|:        |....|:||
Human   477 SSCSCLDSRL----------------HLDGWEVGADDA-ETAEMIAHR--------TGGMKLSAT 516

  Fly   540 RTLQRLRLPSSDNEPLAEPTTIK---ASEEHMQQPSGRHRDSHSHRHHQRHHHHHHH-------- 593
            ....    |.|       ||::.   |::|...:|.....|...|:......:...|        
Human   517 VIFN----PKS-------PTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSCVCCGSC 570

  Fly   594 ----------------------------------RHPHQHQHRQPHPHRTTRSGRK-------RC 617
                                              |.| :.|...|.|.....:||:       :|
Human   571 GDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAP-ERQEEAPPPSEDASNGREPKAPTSDKC 634

  Fly   618 ------------------------------SLEAADPERIQPDREQNLASGDTSAASSLSDD--- 649
                                          .|.|..|.  ..:..|.|:...:|.|.|.|.|   
Human   635 LPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPS--AHEAPQALSGSSSSTAGSCSSDKMG 697

  Fly   650 ------VSLAMRNTT---ARLKFKSTENLLHRLFVCIAGVADQLQTNFASDLRQILRSVFLMNMS 705
                  .:.|....|   .|.:|..:.:|:|||||||:|||||||||:|||||.||::       
Human   698 PEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKT------- 755

  Fly   706 TAQEEIDIPEKTKESELFEFRASENDVIQESAGSNQSIYSAEEVNPELDNVFSAGGGNQATGQRH 770
                            |||..|::                     ||.|                
Human   756 ----------------LFEVMATK---------------------PETD---------------- 767

  Fly   771 SAGASMQRNNTIDLASQPGEGSPSGATTATSRSHVTRSRSLGDQEAASSATSSTAQLRQLEQQQQ 835
                                                      |:|          :||::.|..:
Human   768 ------------------------------------------DKE----------KLRKVTQTLR 780

  Fly   836 QQQLQIQLQRQRNNSVGSNTPSSASSTSSSSEQNSPVSARSGSRRRLQSNNETQMPSSATSTSAT 900
            ...|:              ..:....|.||||  .....|.|...                    
Human   781 SAALE--------------DCALCQETLSSSE--LAAKTRDGDFE-------------------- 809

  Fly   901 LSPPAWIPDGKAPRCMACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCY 965
             .||.|:||.....|.||:.|||..||:||||:||.|....|            |:.....:..:
Human   810 -DPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKVGETPC------------TEGPSASKGVH 861

  Fly   966 VREVRSG 972
            .:.:|||
Human   862 GQSLRSG 868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6051NP_001097943.1 FYVE_LST2 902..966 CDD:277270 22/63 (35%)
ZFYVE28XP_006713963.1 PHD_SF 810..>845 CDD:304600 19/34 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149910
Domainoid 1 1.000 405 1.000 Domainoid score I716
eggNOG 1 0.900 - - E1_KOG1819
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 501 1.000 Inparanoid score I1369
Isobase 1 0.950 - 0.946395 Normalized mean entropy S4566
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D215217at33208
OrthoFinder 1 1.000 - - FOG0005719
OrthoInspector 1 1.000 - - oto91730
orthoMCL 1 0.900 - - OOG6_107592
Panther 1 1.100 - - LDO PTHR46465
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4713
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.710

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