Protein Alignment CG6051 and RUFY2

DIOPT Version :9

• Sequence 1: NP_001097943.1
• Gene: CG6051 / 43271
• FlyBaseID: FBgn0039492
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: NP_060457.4
• Gene: RUFY2 / 55680
• HGNCID: 19761
• Length: 641
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 106/557 - (19%)
• Similarity: 180/557 - (32%)
• Gaps: 162/557 - (29%)

  Fly   448 DDDIDVDEEDIESSDDGTDEEQLLK---DIVSADCASGYLIPNTNLGNLLQPQEVPLTDNFVASE 509
            |.::.|..||::|.....|....||   ||       |....|..:..:|..:      |:|...
Human   196 DANLCVKGEDLDSQVGVIDFSMYLKNEEDI-------GNKERNVQIAAILDQK------NYVEEL 247

  Fly   510 DDEYGTAEQQGHQGLEEDEPSTSAAMLAATRTLQRLRLPSSDNEPLAEPTTIKASEEHMQQPSGR 574
            :.:..:.....|..::..|.|.       |:.::.|        .:|:...||..||:
Human   248 NRQLNSTVSSLHSRVDSLEKSN-------TKLIEEL--------AIAKNNIIKLQEEN------- 290

  Fly   575 HRDSHSHRHHQRHHHHHHHRHPHQH---------QHRQPHPHRTTRSGRKRCSLEA----ADPER 626
                    |..|..:........||         ...|.:.|  :|.|......||    .|..:
Human   291 --------HQLRSENKLILMKTQQHLEVTKVDVETELQTYKH--SRQGLDEMYNEARRQLRDESQ 345

  Fly   627 IQPDREQNLASGDTSAASSLSDDVSLAMRNTTARLKFKSTENLLHRLFVCIAGVADQLQTNFASD 691
            ::.|.|..||     ...|:..::.|||         |..|..:|.....:.|:..||:
Human   346 LRQDVENELA-----VQVSMKHEIELAM---------KLLEKDIHEKQDTLIGLRQQLE------ 390

  Fly   692 LRQILRSVFLMNMSTAQEEIDIPEKTKESELFEFRASENDVIQESAGSNQSIYSAEEVNPELDNV 756
                                            |.:|...::.|:..||...:....|:...|:
Human   391 --------------------------------EVKAINIEMYQKLQGSEDGLKEKNEIIARLE-- 421

  Fly   757 FSAGGGNQATGQRHSAGASMQRNNTIDLASQPGEGSPSGATTATSRSHVTRSRSLGDQEAASSAT 821
                                ::.|.|..|.:..|.....|..|...:.....:.|  ||..|.:.
Human   422 --------------------EKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYL--QECLSKSD 464

  Fly   822 SSTAQLRQLEQQQQQQQLQIQLQRQRNNSVGSNTPSSASSTSSSSEQNSPVSARSGSRRRLQSNN 886
            |...|:.|.|:|..|.:..::::::...::..:......:.|....:...:.:.......||..|
Human   465 SLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDEN 529

  Fly   887 ----------------------ETQMP-SSATSTSATLSPPAWIPDGKAPRCMACQTPFTAFRRR 928
                                  |:::. ......:..|....|:.|.:|..|..|:..|:..:|:
Human   530 QQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSKRK 594

  Fly   929 HHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRDCY 965
            |||||||.:||..||:...|||  ...|.||||..|:
Human   595 HHCRNCGEIFCNACSDNELPLP--SSPKPVRVCDSCH 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6051	NP_001097943.1	FYVE_LST2	902..966	CDD:277270	27/64 (42%)
RUFY2	NP_060457.4	RUN	80..201	CDD:367169	1/4 (25%)
		Smc	245..>571	CDD:224117	64/433 (15%)
		FYVE_RUFY2	569..639	CDD:277298	27/63 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2108
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870