DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6051 and Plekhm2

DIOPT Version :9

Sequence 1:	NP_001097943.1	Gene:	CG6051 / 43271	FlyBaseID:	FBgn0039492	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	NP_001178696.1	Gene:	Plekhm2 / 313667	RGDID:	1307005	Length:	1031	Species:	Rattus norvegicus

Alignment Length:	896	Identity:	166/896 - (18%)
Similarity:	270/896 - (30%)	Gaps:	340/896 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 RQNQDKVLAITNLIMEELLG-----EDRDPRAFRAKFPEEVLQ---ENLAGQLWFGAECLAAGSS 112
            |:.:|::|...:|.:::|..     ||..| |.|..  ::|||   |:|...|.:|.:.|::|..
  Rat     4 REVKDRILENISLSVKKLQSYFAACEDETP-AIRNH--DKVLQRLCEHLDHALLYGLQDLSSGYW 65

  Fly   113 IM----NRETESKEMRPLAQAVTKSLGNVRVLLRDQCLKNNVPNSKTLHLDLNDSTTEQLYESLK 173
            ::    .|....:::..| |.|..:||..|.               .|:|.||::       ||:
  Rat    66 VVVVHFTRREAIRQIEVL-QHVATNLGRSRA---------------WLYLALNEN-------SLE 107

  Fly   174 IFDRLFAEFELSYVSAMVQVKSRHEYEMQQWIGVLFSETLQRALKIGLLDQEMVDAFDPGLMFSI 238
            .:.|||                      |:.:|:|....::.||         |.:.|...:|
  Rat   108 SYLRLF----------------------QENLGLLQKYYVRNAL---------VCSHDHLTLF-- 139

  Fly   239 PRLAIVAGLVVYAKGPLNMDMPGDQLSEMFRPFRTILIKIRDLLRNLNNQELYQLEKLLCTNEDI 303
              |.:|:|| .:.:..|::|.|...|:    |:.               .:.|:.:.||    |.
  Rat   140 --LTLVSGL-EFIRFDLDLDAPYLDLA----PYM---------------PDYYKPQYLL----DF 178

  Fly   304 NTKVPLGSSSIEAPSPEHSSHPTTSSSQNNNNSSNNNHSSSSTNTTSTTTTTAGTTNTHRTVERL 368
            ..::|   ||:                          |.|.|.:..|
  Rat   179 EDRLP---SSV--------------------------HGSDSLSLNS------------------ 196

  Fly   369 VDQRNNNHNSNSNSSTNPTVEAATLRSPSMLSLSATSTPTASPAPSPTPSHSIASTSSAATSSTN 433
                     .||.:|||...:.:.:                  ||| :..:.......|..|.
  Rat   197 ---------FNSVTSTNLEWDDSAI------------------APS-SEDYDFGDVFPAVPSV-- 231

  Fly   434 PPADWSDGDDEDEDDDDIDVDEEDIESSDDGT----------DEEQLLKDIVSADCASGYLIPNT 488
            |..||.|||..|........ ..|:.||...|          :|||       |:.||
  Rat   232 PSTDWEDGDLTDTISGPRST-ASDLTSSKASTKSPTQRHNPFNEEQ-------AESAS------- 281

  Fly   489 NLGNLLQPQEVPLTDNFVASEDDEYGTAEQQGHQGLEEDEPSTSAAMLAATRTLQRLRLPSSDNE 553
                               ||.....|..|:..:....|:|. :...|...|..::.::......
  Rat   282 -------------------SETTPVHTTSQEKEEAQAPDQPD-ACTELEVIRVTKKKKIGKKKKT 326

  Fly   554 PLAEPTTIKASEEH---MQQPSGRHRDSHSHRHHQRHHHHHHHRHPHQHQHRQPHPHRTTRSGRK 615
            .|.|    :||..|   .||..||..|...                              ..|..
  Rat   327 KLDE----EASPLHPNCSQQKCGRQGDGDG------------------------------LVGTP 357

  Fly   616 RCSLEAADPERIQPDREQNLASGDTSAASSLSDDVSLAMRNTTARLKFKSTENLLHRLFVCIAGV 680
            ..:...:|.....| :||....|.|:.:...|:...:.:  ....:|..|.|.|...|    :.|
  Rat   358 GLARNCSDTILASP-QEQGEGPGSTAGSCEHSELSQMGL--LIPEMKDTSMECLGQPL----SKV 415

  Fly   681 ADQLQTNFASDLRQILRSVFLMNMSTAQEEI------DIPEKTKESELFEFRASENDVIQESAGS 739
            .|||.       .|:..|.:...:....:..      :.|||....:..|...:..|..:.:..|
  Rat   416 IDQLH-------GQLDPSTWCSRVEPPDQSFRTGSPGEAPEKPPFCDFSEGLPAPMDFYRFTVES 473

  Fly   740 NQSIYSAEEVNPELDNVFSAGGGNQATGQRHSAGASMQRNNTIDLASQPGEGSPSGATTATSRSH 804
            ..::              :.|||:      |....|.|..:.      ||..:|:.......|..
  Rat   474 PSTV--------------APGGGH------HDPPGSSQPLHV------PGSPAPALQEEEGGRGE 512

  Fly   805 VTRSRSLGDQEAASSATSSTAQLRQLEQQQQQQQLQIQLQRQRNNSVGSNTP------------- 856
            ...|:.|.||:.        .::::.|.|:...||.:..|......|....|
  Rat   513 GQTSQPLEDQQG--------KEIQEPEPQEPDSQLPLVSQEPGPEPVSQPEPGTQETLCKLKGDQ 569

  Fly   857 -----SSASSTSSSSEQNSPVSARSGSRRRLQSN------------NETQM 890
                 |||..:.....|.||......|..|:.:|            ||.|:
  Rat   570 PSPCLSSAEDSGVDEGQGSPSEMTHPSEFRVDNNHLLLLMIHVFRENEEQL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6051	NP_001097943.1	FYVE_LST2	902..966	CDD:277270
Plekhm2	NP_001178696.1	RUN	93..156	CDD:214736	23/120 (19%)
		PH	784..885	CDD:278594
		PH_SKIP	785..887	CDD:270119
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343807
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930