DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6051 and Rufy1

DIOPT Version :9

Sequence 1:	NP_001097943.1	Gene:	CG6051 / 43271	FlyBaseID:	FBgn0039492	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	NP_766145.1	Gene:	Rufy1 / 216724	MGIID:	2429762	Length:	712	Species:	Mus musculus

Alignment Length:	392	Identity:	95/392 - (24%)
Similarity:	152/392 - (38%)	Gaps:	89/392 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 CSLEAADPERIQPDREQNLASGDTSAASSLSDDVSLAMRNTTARLK-FKSTENLLHRLFVCIAGV 680
            |||:    :..|..||||....:.|..|     |.:..::|...|: :|.|...|..::
Mouse   355 CSLQ----KEQQQLREQNEVIRERSEKS-----VEITKQDTKVELETYKQTRQGLDEMY------ 404

  Fly   681 ADQLQTNFASDLRQILRSVFLMNMSTAQE-EIDIPEKTKESELFEFRASENDVIQES---AGSNQ 741
                     ||:.:.|:....:.:...:| |:.|..|| |.|: ..:..|.|..::.   ....|
Mouse   405 ---------SDVWKQLKEEKKVRLELEKELELQIGMKT-EMEI-AMKLLEKDTHEKQDTLVALRQ 458

  Fly   742 SIYSAEEVNPEL-DNVFSAGGGNQATGQRHSAGASMQRNNTIDLASQPG-----EGSPSGATTAT 800
            .:...:.:|.:: ..|.||....|   |::.|.||.:...|..::|...     :.:......|.
Mouse   459 QLEEVKAINLQMFHKVQSAESSLQ---QKNEAIASFEGKTTQVMSSMKQMEERLQQAERARQAAE 520

  Fly   801 SRSHVTRSRSLGDQEAASSATSSTAQLRQLEQQ------------QQQQQLQIQLQRQRNNSVGS 853
            .|||..:      ||.:...::...||.||..|            :|:|.||.:|||:::.|...
Mouse   521 ERSHKLQ------QELSGRGSALQLQLSQLRDQCSGLEKELKSEKEQRQALQRELQREKDTSCLL 579

  Fly   854 NT----------------PSSASSTSSSSEQNSPVSAR----SGSRRRLQSNNETQMPSSATSTS 898
            .|                ...|.......||...:...    |.|:.:::...|         .:
Mouse   580 QTELQQVEGLKKELRELQDEKAELRKVCEEQEQALQEMGLHLSQSKLKMEDIKE---------VN 635

  Fly   899 ATLSPPAWIPDGKAPRCMACQTPFTAFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKAVRVCRD 963
            ..|....|:.|.:|..|..|:..|:..||:|||||||.:||..||:....||.|  .|.||||..
Mouse   636 KALKGHTWLKDDEATHCKQCEKDFSISRRKHHCRNCGHIFCNTCSSNELALPSY--PKPVRVCDS 698

  Fly   964 CY 965
            |:
Mouse   699 CH 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6051	NP_001097943.1	FYVE_LST2	902..966	CDD:277270	28/64 (44%)
Rufy1	NP_766145.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		RUN	151..274	CDD:280855
		DUF3422	<444..589	CDD:295160	33/153 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..532		7/39 (18%)
		Interaction with RAB4. /evidence=ECO:0000269\|PubMed:11172003	619..629		2/9 (22%)
		FYVE_RUFY1	638..708	CDD:277297	29/65 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840