DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6051 and RUNDC3B

DIOPT Version :9

Sequence 1:	NP_001097943.1	Gene:	CG6051 / 43271	FlyBaseID:	FBgn0039492	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	NP_612147.1	Gene:	RUNDC3B / 154661	HGNCID:	30286	Length:	473	Species:	Homo sapiens

Alignment Length:	483	Identity:	102/483 - (21%)
Similarity:	167/483 - (34%)	Gaps:	100/483 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KSLLARFFHAD-RSLTAVASELDSFDGRAEPDR-CTRLVSRLRQNQDKVLAITNLIMEELLGEDR 78
            |||.||....: |:|..|.    .|..:...|| |...:.......:...||...|:...|.|..
Human    22 KSLSARNAAVERRNLITVC----RFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHRLKEIS 82

  Fly    79 DPRAFRAKFPEEVLQENLAGQL-WFGAEC---------LAAGSSIMNRETESKEMRPLAQAVTKS 133
            ....:.|.     ||..|.||: |||.|.         :|......|.....:.|..::.:..|.
Human    83 QSCRWLAH-----LQIPLQGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKG 142

  Fly   134 LGNVRVLLRDQCLKNNVPNSKTLHLDLND-STTEQLYE------------------SLKIFDRLF 179
            ...:||.|.::.|      |:.:...|.| .||.:.||                  .|...|..|
Human   143 RAWIRVALMEKHL------SEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSF 201

  Fly   180 --------AEFE--------LSYVSAMVQVKSRHEYEMQQWIGVLFSETLQRALKIG---LLDQE 225
                    ..|.        |.|:.:...:.|..| |::. :|...||: .....:|   |:|:.
Human   202 CLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEE-ELRT-LGSSGSES-STPENVGPPFLMDEN 263

  Fly   226 MVDAFDPGLMFSIPRLAIVAGLVVYAKGPLN--MDMPGDQLSEMFRPFRTILIKIR--DLLRNLN 286
                   .......|:.....|.:..||.|.  :.:..:||||.....:.:|.:|.  ||...|.
Human   264 -------SWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLE 321

  Fly   287 NQEL-YQLEKL-----LCTNEDINTKVPLGSS-SIEAPSP---EHSSHPTTSSSQNNNNSSNNNH 341
            .::| |.:.:|     :..|.|:.::..|.:. :.:.|||   :.::....:.....:|......
Human   322 KEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYEK 386

  Fly   342 SSSSTNTTSTTTTTAGTTNTHRTVERLVDQRNNNHNSNSNSSTNPTVEAATLRSPSMLSLSATST 406
            |..|.:..|...:.:.|:         :|...:........:.|...|... .:||:|.|..:.|
Human   387 SYQSLDQLSAEVSLSQTS---------LDPGQSQEGDGKQDTLNVMSEGKE-DTPSLLGLCGSLT 441

  Fly   407 PTASPAPSPTPSHSIASTSSAATSSTNP 434
            ..|| ..|.|...|....:|..|..|:|
Human   442 SVAS-YKSLTSLKSNDYLASPTTEMTSP 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6051	NP_001097943.1	FYVE_LST2	902..966	CDD:277270
RUNDC3B	NP_612147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		1/1 (100%)
		RUN	65..203	CDD:397055	33/148 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..428		4/37 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930