DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5882 and ORY

DIOPT Version :9

Sequence 1:	NP_651540.1	Gene:	CG5882 / 43269	FlyBaseID:	FBgn0039490	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001015498.5	Gene:	ORY / 3355174	FlyBaseID:	FBgn0046323	Length:	914	Species:	Drosophila melanogaster

Alignment Length:	903	Identity:	226/903 - (25%)
Similarity:	442/903 - (48%)	Gaps:	115/903 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DEPLVPD-----DFDDDFYKE---LCDKIPEATK---ALRQKDTPNNADNVQRLLICGSRYKSDL 62
            ||..|.|     |.:|:|:.|   :...:.||.:   |.|.|...:...|:.|      ||..
  Fly    31 DETDVLDLNLYSDINDEFFNEANRVVQFLMEAKRHFEASRIKRYSDIIFNLHR------RYVD-- 87

  Fly    63 RLEKERSQELRKEIESLEERLENAARVTKLDMATIEELRGVIEGAWKQKDAAQIREQSAQDEVLS 127
              |...::.||.:|.|.|::|..|..:|......:::|:.::..|||:.||:.:|||..|::
  Fly    88 --EVNDNEVLRPQILSSEKKLRLALELTSTSEEAMQKLKDLLGDAWKESDASALREQLVQEK--- 147

  Fly   128 LREKLDESEQMVAHLNE---------KRLAMSKRDDGKERERLNAEIADLNKRLHLQRTYATELD 183
            |:|.|.:.|.: |..|.         ..||..|....:||:||..|:.||.|||...|.|:..|:
  Fly   148 LQEVLIKCEGL-ADRNSGTTDDTAEFGHLAKYKNIILRERDRLAGEVVDLEKRLATNRYYSENLE 211

  Fly   184 HTIEGLEAKNKELLKLLDETSSDACNLKRKSDALTKELSTMKTEESRYQEQISQMKSANEHLTKV 248
            :.|...|....::.........:..|::.|..||.|   ||:.::..:.:.:.::..||..|::.
  Fly   212 YIIRNNEDAMSKMASRAKFAEGERLNVESKLRALMK---TMEEQKEAHGKTMMKLDIANRELSET 273

  Fly   249 KVRQNLQILSL---KTNLEHLNTQHNAANNKLAKITVDLEYTVQERDKNKRALNQRINLLKVRED 310
            ..:.:.:|...   :.:|:...::.||.|..:.|...|:....:.:..|:..:.|   |..:.::
  Fly   274 TRKLSQKISDYDRQRVHLDKYRSEVNALNKAMHKNEDDISDLTKNQKNNEEMIKQ---LRLIEKE 335

  Fly   311 ELIKVRQDNGKLAKSQE----AIARKYAVLDEAKREVETLN---IRLRTQLGTQDKEL------- 361
            :...|.|...:|.||.|    |..|.|    :..|:|..||   :||:..:.:.:|::
  Fly   336 KSNAVSQLTSRLKKSIEDQNNATTRMY----KLNRKVMMLNSEILRLKNNINSLEKDVLNANGRT 396

  Fly   362 ESMRRVVHHFEKNNENLTKERDSLRRELQAEHHQLEQSNAQHQEAQHEVRALKDTITTMDTKLKK 426
            :.:||:       .|.|.:||||||.::      ::.:|.. .:.:|::....:.|::::..:.|
  Fly   397 DDIRRI-------KETLQRERDSLRSDI------IKLNNTM-ADLKHDMMLKANMISSLNLDMNK 447

  Fly   427 LN---EDA----NKLKKEKTKKLDEIQHWIDKLDALQNEMHLKENYEIELKRTISDLEAKCSKFQ 484
            ||   ::|    :|.:||:.:...|::...::::..|:::.||.:...:|...:.:.:.:...::
  Fly   448 LNVKLDEAYILKSKAEKERDEMAQEMETLHERIENYQDQISLKTSQVNDLTEKLHEKQREVHSYK 512

  Fly   485 QQHDGLAAERQTLQRSVQLADEERQKLRDQLVNLQAHVEKLKAKIGYRDGEISRLQLQIDRMEKE 549
            :|.:.:.:|:..|||:::...:||...|.........:::|..:|...:.:|:.|.|:|:.:...
  Fly   513 KQLESVHSEKMMLQRNLENTTQERDNFRILQAKSGHQIQQLTTEISANEVKINSLNLKIEHLNNY 577

  Fly   550 RRLLRNEIRHAQLGQQHTKAELLDKRKENDRHAKSLQEDEQKLARLRKDVDNLMNEKNAISAALT 614
            .:.|::::::.:......:.::.:.:.:|:..||::..||.|..::..:::.:..|:|.:...:.
  Fly   578 IKELQSDLKNKENLVAALRKDMREMKAKNEMLAKTISNDELKFMKMGHELEEMRKERNLVGLQMV 642

  Fly   615 KRNEEFDRLKHSQENLQTVYDQTQRQCSQYQDDMRLMGVEIKNLRTERDVLRADRESAADLRQEL 679
            :||:|...:|...:..|...|....|.:|..:|:||:..||.||.||.:.|:...:|.||:|:|:
  Fly   643 RRNDEIVVIKEKLQIAQNALDNGTTQYNQRVEDIRLLKKEISNLHTESECLKHAIKSTADMRKEI 707

  Fly   680 LQMHRMLNQERIKARALQDEMVTPMNVHRWRLLSGKDPEKMDLLGRISILRKQLLQQNVAASEQE 744
            :::.|.||||.|:.|||.::..||..|||||:|.|:||:|.:||.::.:|:|:.|:|::..|..:
  Fly   708 VRLQRALNQEHIRIRALTEDARTPTGVHRWRILKGEDPKKFELLEKLQLLQKRSLKQSIENSNLK 772

  Fly   745 RALNEAQQLYAALREFMLKLPS----HK--VRAELNSVKANLSAKDRKLKVLKAELSAREADEKS 803
            ..|.|||:....|:..:..:|:    ||  |:..:|...|      :|||.|.||.|....:.||
  Fly   773 NKLCEAQKTNETLKRMLSHMPTVEIKHKLVVQQRINRQMA------KKLKTLAAERSLDMVELKS 831

  Fly   804 KK-------EKLEEMRVSLALT------KTQLLEEK----KHKQKLLEERQLLEQMHC 844
            ::       .|:.|:.....|:      |:.:|:.|    |....|:.:    |.|.|
  Fly   832 RQCIINSFAGKISEIGELSILSDGKNEIKSAILDVKNEISKSNMSLVPQ----EYMEC 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5882	NP_651540.1	Smc	61..>699	CDD:224117	159/670 (24%)
ORY	NP_001015498.5	Smc	<182..488	CDD:224117	73/329 (22%)
ORY	NP_001015498.5	SMC_prok_B	<363..686	CDD:274008	68/336 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439839
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53505
OrthoDB	1	1.010	-	-		D1077673at2759
OrthoFinder	1	1.000	-	-		FOG0006172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103263
Panther	1	1.100	-	-	P	PTHR32083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5074
SonicParanoid	1	1.000	-	-		X4455
	9	8.890