DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5880 and ZDHHC18

DIOPT Version :9

Sequence 1:	NP_651539.3	Gene:	CG5880 / 43268	FlyBaseID:	FBgn0039489	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_115659.1	Gene:	ZDHHC18 / 84243	HGNCID:	20712	Length:	388	Species:	Homo sapiens

Alignment Length:	305	Identity:	70/305 - (22%)
Similarity:	111/305 - (36%)	Gaps:	102/305 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NYTHCLGPFFVV---GVAALTTSVVSIAYWIGLPFWWAKSQLVTYFLLIVGNWLLLNVVFHYVMA 118
            |..:|.|...:.   ||.|||  ::.|....||.|.:....|.....|.:.  ::..::|.:||:
Human    77 NRFYCGGRLMLAGHGGVFALT--LLLILTTTGLFFVFDCPYLARKLTLAIP--IIAAILFFFVMS 137

  Fly   119 VITPAGHPPEGV----SLVEAVSM--------------------------------CGKCIAPKP 147
            .:........|:    ::.||.::                                |..|...:|
Human   138 CLLQTSFTDPGILPRATVCEAAALEKQIDNTGSSTYRPPPRTREVLINGQMVKLKYCFTCKMFRP 202

  Fly   148 PRTHHCSICNRCILKMDHHCPWLNNCVGYGNHRYFFLY---------------MTYTTLG----- 192
            |||.|||:|:.|:.:.||||||:.||||..|:|:|:.:               :|:.||.
Human   203 PRTSHCSVCDNCVERFDHHCPWVGNCVGRRNYRFFYAFILSLSFLTAFIFACVVTHLTLRAQGSN 267

  Fly   193 -----------------CLFLI--LFGLEIGHKYLWLDHGENWTEIEPLEGQ-PVKFNLSGHIIP 237
                             |.|.|  :.||...|.||   ...|.|..|.::|. ..|......:.|
Human   268 FLSTLKETPASVLELVICFFSIWSILGLSGFHTYL---VASNLTTNEDIKGSWSSKRGGEASVNP 329

  Fly   238 VTHPNEYDEFV------LPPAVHN----------LPTPIVDTDAA 266
            .:|.:......      |||::.:          ||:||...:.|
Human   330 YSHKSIITNCCAVLCGPLPPSLIDRRGFVQSDTVLPSPIRSDEPA 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5880	NP_651539.3	zf-DHHC	139..>201	CDD:279823	30/100 (30%)
ZDHHC18	NP_115659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		zf-DHHC	191..314	CDD:279823	38/125 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..388		5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810