DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5880 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_651539.3	Gene:	CG5880 / 43268	FlyBaseID:	FBgn0039489	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	357	Identity:	86/357 - (24%)
Similarity:	140/357 - (39%)	Gaps:	120/357 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 IAYWIGLPF-----WWA----KSQLVTYFLLIVGNWLLLNVVFHYVMAVIT-------------- 121
            :.|||.:.|     .|:    ..||....:..:|..::..:.:|.:.|:..
Mouse    16 VLYWIPVVFISLLLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNP 80

  Fly   122 -----------------PAGHPPEGV-------------SLVEAVSMCGKCIAPKPPRTHHCSIC 156
                             |.|...:.|             ::..|:..|.:|...||.|.||||:|
Mouse    81 SKEFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSVC 145

  Fly   157 NRCILKMDHHCPWLNNCVGYGNHRYFFLYMTYTTLGCLFLILFGLEIGHKYLWLDHGENWTEIEP 221
            ::|||||||||||:|||||:.|:::|.|::.|:.|.|||:....|:...::        ||
Mouse   146 DKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIRF--------WT---- 198

  Fly   222 LEGQPVKFNLSGHIIPVTHPNEYDEFVLPPAVHNLPTPIVDTDAASPGRRRALWFMAFTNVAVVL 286
                                            :.||    ||.|     :..:.|:.|......:
Mouse   199 --------------------------------NGLP----DTQA-----KFHIMFLFFAAAMFSV 222

  Fly   287 ALGSLSIWHAKLITRGETSVEAHINEAERKRHLQQQRIYINPYNFGTKKNWKLFLGLVRGRSFWR 351
            :|.||..:|..|:::.::::||..|..  .||...:    |.::.|..||.:...|  ..:.:|
Mouse   223 SLSSLFGYHCWLVSKNKSTLEAFRNPV--FRHGTDK----NGFSLGFSKNMRQVFG--DEKKYW- 278

  Fly   352 TVLLPSWHKPEGTGLSFHT--VNDAPFEDEWP 381
              |||.: ..:|.|.||.|  ||..|.:...|
Mouse   279 --LLPVF-SSQGDGCSFPTCLVNQDPEQPSTP 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5880	NP_651539.3	zf-DHHC	139..>201	CDD:279823	34/61 (56%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	51/173 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366		4/12 (33%)
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366		3/10 (30%)
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55511
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830