DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5880 and Hip14

DIOPT Version :9

Sequence 1:	NP_651539.3	Gene:	CG5880 / 43268	FlyBaseID:	FBgn0039489	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	102/443 - (23%)
Similarity:	156/443 - (35%)	Gaps:	131/443 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTRITWRGHSTQELLSIL-------RLRWSYMKHCWHSLTFNA----HMNSSYASDV----CLTP 50
            |.|:.....::|:..|:|       ||||..|..|..:..:.|    .:|:.|....    ||..
  Fly   268 MDRVKEAALTSQQRRSLLSKLRHDKRLRWWSMVACPFTAFYLAGIVFTVNTLYIIKFFLLGCLYS 332

  Fly    51 IFWFV-----DNYTHCLGPFFVVGVAALTTSVVSIAYWI-----GLPFWWAKSQLVTYFLLIVGN 105
            ||..:     |.:...|.|..|.    |.|.......|:     .:.|......|::..||
  Fly   333 IFHTIGKALFDEHLMALLPLSVY----LATKAWFYVTWLMYIDDAVSFTATVCFLISSLLL---- 389

  Fly   106 WLLLNVVFHYVMAVITPAGH---------PPEGVSLVEAVSMCGKCIAPKPPRTHHCSICNRCIL 161
            |:.....:.....:|.|...         ...|....|..|.|..|:..:|.|:.|||:|:||:.
  Fly   390 WVCFLKSWKGDPGIIRPTREQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVA 454

  Fly   162 KMDHHCPWLNNCVGYGNHRYFFLYMTYTTLGCLFLILFGLEIGHKYLWLDHGENWTEIEPLEGQP 226
            :.||||||:.||:|..||.||..::....:.|.:: |:|   |.||.
  Fly   455 RFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWM-LYG---GSKYY------------------ 497

  Fly   227 VKFNLSGHIIPVTHPN-EYDEFVLPPAVHNLPTPIVDTDAASPGRRRAL--------WFM--AFT 280
                       |...| .:|:|:                    |..||:        |.|  |..
  Fly   498 -----------VNQCNVRFDDFL--------------------GAMRAIGNCDAWVGWVMGNALL 531

  Fly   281 NVAVVLALGSLSIWHAKLITRGETSVEAHINEAERKRHLQQQRIYINPYNFGTKKNWKLFL---- 341
            :::.|:.|.....:  ::|..|.|:.| .:|.. |.||.|.:..: :|:..|..:|...||
  Fly   532 HMSWVILLTICQTY--QVICLGMTTNE-RMNRG-RYRHFQAKGGH-SPFTRGPIQNLVDFLECSC 591

  Fly   342 -GLVR-GRSFWRTVL--------------LPSWHKPEGTGLSFHTVNDAPFED 378
             |||: .|..|....              |.|...|:|.......| |..:.|
  Fly   592 FGLVQPKRVDWMNYYDYDAQTHQTIEKEPLLSVDCPDGMAGDHQYVXDKTYRD 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5880	NP_651539.3	zf-DHHC	139..>201	CDD:279823	25/61 (41%)
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	47/188 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810