DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5880 and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_651539.3	Gene:	CG5880 / 43268	FlyBaseID:	FBgn0039489	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_766142.2	Gene:	Zdhhc17 / 320150	MGIID:	2445110	Length:	632	Species:	Mus musculus

Alignment Length:	302	Identity:	79/302 - (26%)
Similarity:	109/302 - (36%)	Gaps:	105/302 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SVVSIAYWIGLPFWWAKSQLVTYFLLIVGNWLLLNVVFHYV------MAVITPAGHPPEG----- 129
            |.:.:..::...||    ..||:|...   |..||.:|.::      :|:....|...:.
Mouse   356 SALPLGIYLATKFW----MYVTWFFWF---WNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGII 413

  Fly   130 -----------VSLVEAVSM-----CGKCIAPKPPRTHHCSICNRCILKMDHHCPWLNNCVGYGN 178
                       |.|.|..|:     |..|:..||.|:.||.:|||||.|.||||||:.||||.||
Mouse   414 KATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGN 478

  Fly   179 HRYFFLYMTYTTLGCLFLILFGLEIGHKYLWLDHG--ENWTEIEPLEGQPVKFNLSGHIIPVTHP 241
            ||||        :|.||.:||.:      .|:.:|  ..|                |.....|:.
Mouse   479 HRYF--------MGYLFFLLFMI------CWMIYGCVSYW----------------GLHCETTYT 513

  Fly   242 NEYDEFVLPPAVHNLPTPIVDTDAASPGRRRALW-FMAFTN-------VAVVLALGSLSIWHAKL 298
            .:           ...|.|......||      | |..|.|       |||:|......|
Mouse   514 KD-----------GFWTYITQIATCSP------WMFWMFLNSVFHFLWVAVLLMCQLYQI----- 556

  Fly   299 ITRGETSVEAHINE---AERKRHLQQQRIYI-NPYNFGTKKN 336
                 |.:....||   |.|.:|.:.....| :|:|.|..:|
Mouse   557 -----TCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRN 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5880	NP_651539.3	zf-DHHC	139..>201	CDD:279823	34/61 (56%)
Zdhhc17	NP_766142.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000269\|PubMed:25253725	11..305
		ANK repeat	89..120	CDD:293786
		PHA03095	100..>352	CDD:222980
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		Ank_2	161..255	CDD:372319
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		DHHC	438..568	CDD:366691	55/186 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810