DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5880 and ZDHHC1

DIOPT Version :9

Sequence 1:	NP_651539.3	Gene:	CG5880 / 43268	FlyBaseID:	FBgn0039489	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_037436.1	Gene:	ZDHHC1 / 29800	HGNCID:	17916	Length:	485	Species:	Homo sapiens

Alignment Length:	306	Identity:	73/306 - (23%)
Similarity:	111/306 - (36%)	Gaps:	90/306 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 FFVVGVAALTTSVVSIAYWIGLPFWWAKSQLVTYFLLIVGNWLLLNVVFHYVMAVITP------- 122
            |.|:|...|...         ||..|..:.......:..|     ::|.|.....|.|
Human    62 FAVIGFGILVPL---------LPHHWVPAGYACMGAIFAG-----HLVVHLTAVSIDPADANVRD 112

  Fly   123 ---AGHPP-----EGVSLVEAVSMCGKCIAPKPPRTHHCSICNRCILKMDHHCPWLNNCVGYGNH 179
               ||..|     :...::|.:. |..|......|:.|||.||:|:...||||.|||||||..|:
Human   113 KSYAGPLPIFNRSQHAHVIEDLH-CNLCNVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGERNY 176

  Fly   180 RYFFLYMTYTTLGCLFLILFGLEIGHKYLWLDHGENWTEIEPLEGQPVKFNLSGHI-IPVTHPNE 243
            |.|...:....||.|.|:|..     .|::::...|          |::...:.|. :...|.:.
Human   177 RLFLHSVASALLGVLLLVLVA-----TYVFVEFFVN----------PMRLRTNRHFEVLKNHTDV 226

  Fly   244 YDEFVLPPAVHNLPTPIVDTDAASPGRRRALWFMAFTNVAVVLALGSLS--------------IW 294
            :..|        ||...|:|.|.      |:..:|    |:::.||.||              :|
Human   227 WFVF--------LPAAPVETQAP------AILALA----ALLILLGLLSTALLGHLLCFHIYLMW 273

  Fly   295 HAKLIT-------RGETSVEAHINEAE----RKRHLQQQRIYINPY 329
            | ||.|       |.....:....|.|    :.|.:|:...|:..:
Human   274 H-KLTTYEYIVQHRPPQEAKGVHRELESCPPKMRPIQEMEFYMRTF 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5880	NP_651539.3	zf-DHHC	139..>201	CDD:279823	28/61 (46%)
ZDHHC1	NP_037436.1	Mediates interaction with STING1. /evidence=ECO:0000269\|PubMed:25299331	1..271		62/256 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		zf-DHHC	129..284	CDD:307600	52/189 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..358
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810