DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5880 and ZDHHC20

DIOPT Version :9

Sequence 1:	NP_651539.3	Gene:	CG5880 / 43268	FlyBaseID:	FBgn0039489	Length:	381	Species:	Drosophila melanogaster
Sequence 2:	NP_001316988.1	Gene:	ZDHHC20 / 253832	HGNCID:	20749	Length:	365	Species:	Homo sapiens

Alignment Length:	371	Identity:	90/371 - (24%)
Similarity:	138/371 - (37%)	Gaps:	126/371 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WSYMKHCWHSLTFNAHMNSSYASDVCLTPIFWFVDN-----YTHCLGPFFVVGVAALTTSVVSIA 81
            |||.               :|..::|:..||...:|     |......|||:.|         .:
Human    28 WSYY---------------AYVVELCVFTIFGNEENGKTVVYLVAFHLFFVMFV---------WS 68

  Fly    82 YWIGL---------PFWWAKSQLVTYFLLIVGNWLLLNVVF--HYVMAVITPAGH--PPEGVSLV 133
            ||:.:         .|:.:.|:...|           ...|  .....::..|..  |....|..
Human    69 YWMTIFTSPASPSKEFYLSNSEKERY-----------EKEFSQERQQEILRRAARALPIYTTSAS 122

  Fly   134 EAVSMCGKCIAPKPPRTHHCSICNRCILKMDHHCPWLNNCVGYGNHRYFFLYMTYTTLGCLFLIL 198
            :.:..|.||...||.|.||||.|:.|||||||||||:|||||:.|:::|.|::.|:.|.|||:..
Human   123 KTIRYCEKCQLIKPDRAHHCSACDSCILKMDHHCPWVNNCVGFSNYKFFLLFLLYSLLYCLFVAA 187

  Fly   199 FGLEIGHKYLWLDHGENWTEIEPLEGQPVKFNLSGHIIPVTHPNEYDEFVLPPAVHNLPTPIVDT 263
            ..||...|:        ||                        ||                :.||
Human   188 TVLEYFIKF--------WT------------------------NE----------------LTDT 204

  Fly   264 DAASPGRRRALWFMAFTNVAVVLALGSLSIWHAKLITRGETSVEAHINEAERKRHLQQQRIYINP 328
            .|     :..:.|:.|.:....:::.||..:|..|:.:..|::|:          .:.......|
Human   205 RA-----KFHVLFLFFVSAMFFISVLSLFSYHCWLVGKNRTTIES----------FRAPTFSYGP 254

  Fly   329 ----YNFGTKKNWKLFLGLVRGRSFWRTVLLPSWHKPEGTGLSFHT 370
                ::.|..|||:...|  ..:.:|   |||.: ...|.|.||.|
Human   255 DGNGFSLGCSKNWRQVFG--DEKKYW---LLPIF-SSLGDGCSFPT 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5880	NP_651539.3	zf-DHHC	139..>201	CDD:279823	35/61 (57%)
ZDHHC20	NP_001316988.1	zf-DHHC	16..301	CDD:327686	90/371 (24%)
ZDHHC20	NP_001316988.1	Substrate binding. /evidence=ECO:0000305\|PubMed:29326245	140..143		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55511
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830