Protein Alignment CG6066 and NKAP

DIOPT Version :10

• Sequence 1: NP_651538.1
• Gene: CG6066 / 43267
• FlyBaseID: FBgn0039488
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_078804.2
• Gene: NKAP / 79576
• HGNCID: 29873
• Length: 415
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 193/469 - (41%)
• Similarity: 247/469 - (52%)
• Gaps: 101/469 - (21%)

  Fly    38 SVSRERKRERDRELHRERTSNRSSRRSREKDAVPRRRRTRS-SPSRSS------------SSSSS 89
            |.||...||......|.|:|::|.:.|:...: ||.||:|| |.|||.            |..|.
Human     5 SGSRSPDREASGSGGRRRSSSKSPKPSKSARS-PRGRRSRSHSCSRSGDRNGLTHQLGGLSQGSR 68

  Fly    90 DRSSSSRSPSRSRKSRPKSVERWP-----NDRYHENNDRRQNPFRGRAPEGSFINDPAEPSFRSQ 149
            ::|..|||.||||: ||.:....|     :..|:.:..|   |:....|..|.::...|.|.|.:
Human    69 NQSYRSRSRSRSRE-RPSAPRGIPFASASSSVYYGSYSR---PYGSDKPWPSLLDKEREESLRQK 129

  Fly   150 HRGRGSSNHQFKGDSKAVNARRNQRVLIGEEGVPEVWGKSPSRPETDDVELVKGSYIGPKK---- 210
                                |.::|..|||.|.|||||.||..||.|..|........|||
Human   130 --------------------RLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTS 174

  Fly   211 -------KKKKGKRKHKKSEKKSKKKSKKSKKKKSKQESSSSSSSSSSEDSSDESSSSSSSSSSD 268
                   ||||..|..::|:|:.||||.|.|.||..::|.|.|.|.:  |||||
Human   175 ASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSET--DSSDE----------- 226

  Fly   269 SEDESEEEDVWLEKTADGIKKPKKKKSSTSKKDKKSKKKKKKRKSEAEKSKKSSSSSASKS---- 329
                            |..::.||.|....||..:|||.||||   ::||:|.||.|:||.
Human   227 ----------------DNKRRAKKAKKKEKKKKHRSKKYKKKR---SKKSRKESSDSSSKESQEE 272

  Fly   330 ------KNKESASHNDEDVGPSLRPGGSLNQKD----FGKALLPGEGAAMAAYIAEGKRIPRRGE 384
                  |::..|....:.:||. .|....:|.|    :|.|||||||||||.|:..|||||||||
Human   273 FLENPWKDRTKAEEPSDLIGPE-APKTLTSQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGE 336

  Fly   385 IGLTSDEIANFESVGYVMSGSRHRRMEAVRIRKENQLYSADEKRALAMFSKEERQKRENKILSQF 449
            |||||:|||:||..||||||||||||||||:|||||:||||||||||.|::|||:|||||||:.|
Human   337 IGLTSEEIASFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASF 401

  Fly   450 KDMIHSKLQAKDKK 463
            ::|::.|.:.||.|
Human   402 REMVYRKTKGKDDK 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6066	NP_651538.1	Nkap_C	354..454	CDD:461812	78/103 (76%)
NKAP	NP_078804.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..311		113/363 (31%)
		NKAP	120..>176	CDD:464805	23/75 (31%)
		Necessary for interaction with CIR1. /evidence=ECO:0000269|PubMed:19409814	179..272		45/124 (36%)
		Necessary for interaction with HDAC3 and transcriptional repression. /evidence=ECO:0000269|PubMed:19409814	273..415		86/142 (61%)
		Nkap_C	306..405	CDD:461812	75/98 (77%)