DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5815 and spty2d1

DIOPT Version :9

Sequence 1:	NP_733196.1	Gene:	CG5815 / 43266	FlyBaseID:	FBgn0027574	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001072434.1	Gene:	spty2d1 / 779888	XenbaseID:	XB-GENE-5939956	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	870	Identity:	210/870 - (24%)
Similarity:	305/870 - (35%)	Gaps:	385/870 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFGDLLRY--AKKNSDAVTKEVGQGKYYSTKYSPPKKQSKESKQLSSNIQKFLQKKEAEEAEKK 63
            |||..:|:.  ||..||.:.|.      ||....||||..|.....|:.:|.||:||:.|...|:
Frog     1 MDFHSVLKMAAAKPGSDGIAKR------YSLAVGPPKKDPKVKGVDSAAVQAFLRKKDEESRRKE 59

  Fly    64 RLERQKLNDLLAKRDE-KSKNKIRKMLKVTKSANKSVLEDAKDYEGAIDGHEAGEGQGDDYGYVS 127
            .:|::|..||||||.| |...|.|.|...||       ::.|.|.|.
Frog    60 TVEKRKKEDLLAKRKELKHDRKARAMASRTK-------DNFKGYNGI------------------ 99

  Fly   128 TEANAFYDKYIEKVRDVQEDKGFTPSRPQSLKDLSGTKERVKAAITREREEAKGNTRQKSSTSTL 192
                           .::|       :|:..| .|||:|.....:..|.||
Frog   100 ---------------PIEE-------KPRKRK-RSGTEEDQNDNMAAEGEE-------------- 127

  Fly   193 PSSATKSKESSVARSYSTSKTLYDPNAEKLEEERKKRQEEEQRRAKIKRPA---QP--PPMDFQA 252
                           |.|.:.||:.:..:.|:|    :|||....|:.:||   :|  |.::|..
Frog   128 ---------------YMTEEELYEYSQSESEQE----EEEELPPQKVPKPAPGKKPPTPALNFND 173

  Fly   253 LLRLAEKKQHEPVVFEVEKKKEPERLLSAREKRELE--ERQRQQEQR------AQRLKMRES--- 306
            ||||||:||:|||......||| |||.:|.|.:|||  ||:.|:..|      .|.:|:.:.
Frog   174 LLRLAERKQYEPVEVVRPVKKE-ERLRTAEELKELEFLERKAQKADRKDPKRNEQLVKVSKGSGD 237

  Fly   307 -----EGKETPKSIPNRMEPNGRIPKLN------------------QAKPANA------------ 336
                 :|..:..|..:..|.||.|.|.:                  ..||::|
Frog   238 KYSSLKGTHSGNSKSSSTEQNGTIRKSSSDTGSRTEKSGSVFHTKESKKPSSAKDLGGKGSRPNV 302

  Fly   337 -----------------------PSDSFK------------------------------------ 342
                                   ||.|.:
Frog   303 TGDGKDRHSSSQPSAASNSAFGRPSGSARPSGSSGPGRPLGGSGSSSGKSTGGSASGSARSVGGS 367

  Fly   343 --------------------------------------KPT------APQPTKSSASSTSLSSSN 363
                                                  |||      :.:||.||.|:.|:..|.
Frog   368 GSGSGKPMGGSGSGKPIGGLHSSHGSGKPTGGTGSGSGKPTGASGSGSGKPTGSSGSAKSVRESG 432

  Fly   364 SHSSASRSSVSSS---------------------------------------------------- 376
            |.|.:.|.|.|.|
Frog   433 SGSRSVRESGSGSRSVRESGSGSGSARSVRESGSGSGSARSVRESGSGSGSARSVRESGSAKQAG 497

  Fly   377 ---------------RPATKSAQLTARPGA-------------TASAVGKPSSSSSRDV------ 407
                           ||::.|:....:|.|             .:|::|..:|:|||..
Frog   498 GPGSGRALGSGSSFARPSSNSSPAPGKPAAGSGSARPSSSGTPRSSSMGHSTSNSSRQPSSSGAV 562

  Fly   408 --------------PSKNPYAA-TSLKGTVREFPPRDQSSISTLDRRKIPAAAKTRQTPSSD--- 454
                          ||..|.|. ||::......|...:||:.:...|.:.|:|..:..|:..
Frog   563 RPSSGPPTGATPKGPSPRPGAGPTSVRPNSTSVPGSARSSLGSGPGRPVAASATGQLAPAKPKCT 627

  Fly   455 -VQRSQGGRQFPPADVK-----------------RRKPNE--PPVT---KRRIYDDDDEDEYDSE 496
             |..:...:.|.|..:.                 .|.|..  ||:|   ||||   ||:|:||||
Frog   628 VVAETISSKNFVPKSINGHMNGIRTAAPPGHRPAMRPPGPPLPPITSSYKRRI---DDDDDYDSE 689

  Fly   497 LDDFIDD-GDCEEDISSHIRDIFGYDKRRYQGIDDDD---RGMESSFAQVQREEFISKKLGMQED 557
            :|||||| |:|:::||.|||:|||||:.:|:  |:.|   |.|||:|.:.|:||..|.:||:|||
Frog   690 MDDFIDDGGECQDEISKHIREIFGYDRTKYR--DESDYALRYMESTFREQQKEEARSLRLGIQED 752

  Fly   558 LEDMRMEAAHKKQK----KLVAKIS 578
            ||:::.|....|:|    |...|:|
Frog   753 LEELQREEEELKRKAKQLKAAKKMS 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5815	NP_733196.1	SPT2	<500..573	CDD:285455	38/80 (48%)
spty2d1	NP_001072434.1	Important for interaction with DNA. /evidence=ECO:0000250\|UniProtKB:Q68D10	1..665		152/751 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..625		128/656 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..685		12/48 (25%)
		Important for interaction with histones. /evidence=ECO:0000250\|UniProtKB:Q68D10	666..778		57/117 (49%)
		SPT2	693..>750	CDD:285455	30/58 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7282
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007141
OrthoInspector	1	1.000	-	-		otm48639
Panther	1	1.100	-	-	LDO	PTHR22691
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4767
SonicParanoid	1	1.000	-	-		X5240
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.130