Protein Alignment CG5815 and SPTY2D1

DIOPT Version :10

• Sequence 1: NP_733196.1
• Gene: CG5815 / 43266
• FlyBaseID: FBgn0027574
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_919261.2
• Gene: SPTY2D1 / 144108
• HGNCID: 26818
• Length: 685
• Species: Homo sapiens
• Alignment Length: 798
• Identity: 204/798 - (25%)
• Similarity: 284/798 - (35%)
• Gaps: 331/798 - (41%)

  Fly     1 MDFGDLLRYAKKNSDAVTKEVGQG-----KYYSTKYSPPKKQSKESKQLSSNIQKFLQKKEAEEA 60
            |||.::|..|.|         |||     |.||....||||..|.....|:.:|.||::||.|..
Human     1 MDFREILMIASK---------GQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELR 56

  Fly    61 EKKRLERQKLNDLLAKRDE-KSKNKIRKMLKVTK----SANKSVLEDAKDYEGAIDGHEAGEGQG 120
            .|...|:::..:|:.||.| |...|.|.|.|.||    ..|...:|:......|.:.|.:   ||
Human    57 RKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTS---QG 118

  Fly   121 DDYGYVSTEANAFYDKYIEKVRDVQEDKGFTPSRPQSLKDLSGTKERVKAAITREREEAKGNTRQ 185
            .|..|...|.|.|.:.
Human   119 TDREYEMEEENEFLEY------------------------------------------------- 134

  Fly   186 KSSTSTLPSSATKSKESSVARSYSTSKTLYDPNAEKLEEERKKRQEEEQRRAKIKRP--AQPPPM 248
                                            |..:.|:|.::.||..:..:|.|.|  :.||||
Human   135 --------------------------------NHAESEQEYEEEQEPPKVESKPKVPLKSAPPPM 167

  Fly   249 DFQALLRLAEKKQHEPVVFEVEKKKEPERLLSAREKRELEERQRQQEQRAQRLKMRESEGKETP- 312
            :|..|||||||||.|||..:|.||.| ||.::|.|.||     |:..:|..|.|..|::||..|
Human   168 NFTDLLRLAEKKQFEPVEIKVVKKSE-ERPMTAEELRE-----REFLERKHRRKKLETDGKLPPT 226

  Fly   313 --KSIPNRME-----------------------------------------------PNGRI--- 325
              |..|::.|                                               |..||
Human   227 VSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAG 291

  Fly   326 ------PKLNQA--KP----ANAPSDSFKKPTAPQPTKSSASSTSLSS-------SNSHSSASR- 370
                  |.|.:.  ||    |..|..|...|:.|   |:|||.|..|:       |.||.|.||
Human   292 SGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVP---KTSASRTQKSAVEHKAKKSLSHPSHSRP 353

  Fly   371 -------------------SSVSS----------------------------------------- 375
                               ||.||
Human   354 GPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKP 418

  Fly   376 ---SRPATKSAQLTARPGATASAVGKPSSSSSRDVPSKNPYAAT--------------------- 416
               |.|:.::...|..||..||:.|.|....|..|.|..|..::
Human   419 TNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLG 483

  Fly   417 -----------SLKGTV-------REFPPRDQSSI---------------------STLDRRKIP 442
                       |:.|::       ...|.|..||:                     .|:..:.|.
Human   484 PPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNII 548

  Fly   443 AAAKTRQ-----TPSSDVQRSQGGRQFP-PADVKRRKPNEPPVTKRRIYDDDDEDEYDSELDDFI 501
            :.:...|     .|.|..:.:||.::.| |...||::..|.        :|||:||||||::|||
Human   549 SRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEE--------EDDDDDEYDSEMEDFI 605

  Fly   502 -DDGDCEEDISSHIRDIFGYDKRRYQGIDDDD---RGMESSFAQVQREEFISKKLGMQEDLEDMR 562
             |:|:.:|:||.|||:|||||:::|:  |:.|   |.||||:.:.|:||..|.:||||||||:||
Human   606 EDEGEPQEEISKHIREIFGYDRKKYK--DESDYALRYMESSWKEQQKEEAKSLRLGMQEDLEEMR 668

  Fly   563 MEAAHKKQKKLVAKISSR 580
            .| ..:.|::...|:..|
Human   669 RE-EEEMQRRRAKKLKRR 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5815	NP_733196.1	SPT2	<500..572	CDD:462407	39/75 (52%)
SPTY2D1	NP_919261.2	Important for interaction with DNA. /evidence=ECO:0000269|PubMed:23378026	1..570		146/670 (22%)
		PTZ00121	<31..>117	CDD:173412	27/88 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	79..168		28/172 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..615		95/443 (21%)
		PHA03307	284..>540	CDD:223039	47/258 (18%)
		Important for interaction with histones. /evidence=ECO:0000269|PubMed:23378026	571..685		56/124 (45%)
		SPT2	604..667	CDD:462407	35/64 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..685		18/41 (44%)