DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5815 and SPTY2D1

DIOPT Version :9

Sequence 1:	NP_733196.1	Gene:	CG5815 / 43266	FlyBaseID:	FBgn0027574	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_919261.2	Gene:	SPTY2D1 / 144108	HGNCID:	26818	Length:	685	Species:	Homo sapiens

Alignment Length:	798	Identity:	204/798 - (25%)
Similarity:	284/798 - (35%)	Gaps:	331/798 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFGDLLRYAKKNSDAVTKEVGQG-----KYYSTKYSPPKKQSKESKQLSSNIQKFLQKKEAEEA 60
            |||.::|..|.|         |||     |.||....||||..|.....|:.:|.||::||.|..
Human     1 MDFREILMIASK---------GQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELR 56

  Fly    61 EKKRLERQKLNDLLAKRDE-KSKNKIRKMLKVTK----SANKSVLEDAKDYEGAIDGHEAGEGQG 120
            .|...|:::..:|:.||.| |...|.|.|.|.||    ..|...:|:......|.:.|.:   ||
Human    57 RKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTS---QG 118

  Fly   121 DDYGYVSTEANAFYDKYIEKVRDVQEDKGFTPSRPQSLKDLSGTKERVKAAITREREEAKGNTRQ 185
            .|..|...|.|.|.:.
Human   119 TDREYEMEEENEFLEY------------------------------------------------- 134

  Fly   186 KSSTSTLPSSATKSKESSVARSYSTSKTLYDPNAEKLEEERKKRQEEEQRRAKIKRP--AQPPPM 248
                                            |..:.|:|.::.||..:..:|.|.|  :.||||
Human   135 --------------------------------NHAESEQEYEEEQEPPKVESKPKVPLKSAPPPM 167

  Fly   249 DFQALLRLAEKKQHEPVVFEVEKKKEPERLLSAREKRELEERQRQQEQRAQRLKMRESEGKETP- 312
            :|..|||||||||.|||..:|.||.| ||.::|.|.||     |:..:|..|.|..|::||..|
Human   168 NFTDLLRLAEKKQFEPVEIKVVKKSE-ERPMTAEELRE-----REFLERKHRRKKLETDGKLPPT 226

  Fly   313 --KSIPNRME-----------------------------------------------PNGRI--- 325
              |..|::.|                                               |..||
Human   227 VSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAG 291

  Fly   326 ------PKLNQA--KP----ANAPSDSFKKPTAPQPTKSSASSTSLSS-------SNSHSSASR- 370
                  |.|.:.  ||    |..|..|...|:.|   |:|||.|..|:       |.||.|.||
Human   292 SGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVP---KTSASRTQKSAVEHKAKKSLSHPSHSRP 353

  Fly   371 -------------------SSVSS----------------------------------------- 375
                               ||.||
Human   354 GPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKP 418

  Fly   376 ---SRPATKSAQLTARPGATASAVGKPSSSSSRDVPSKNPYAAT--------------------- 416
               |.|:.::...|..||..||:.|.|....|..|.|..|..::
Human   419 TNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLG 483

  Fly   417 -----------SLKGTV-------REFPPRDQSSI---------------------STLDRRKIP 442
                       |:.|::       ...|.|..||:                     .|:..:.|.
Human   484 PPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNII 548

  Fly   443 AAAKTRQ-----TPSSDVQRSQGGRQFP-PADVKRRKPNEPPVTKRRIYDDDDEDEYDSELDDFI 501
            :.:...|     .|.|..:.:||.::.| |...||::..|.        :|||:||||||::|||
Human   549 SRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEE--------EDDDDDEYDSEMEDFI 605

  Fly   502 -DDGDCEEDISSHIRDIFGYDKRRYQGIDDDD---RGMESSFAQVQREEFISKKLGMQEDLEDMR 562
             |:|:.:|:||.|||:|||||:::|:  |:.|   |.||||:.:.|:||..|.:||||||||:||
Human   606 EDEGEPQEEISKHIREIFGYDRKKYK--DESDYALRYMESSWKEQQKEEAKSLRLGMQEDLEEMR 668

  Fly   563 MEAAHKKQKKLVAKISSR 580
            .| ..:.|::...|:..|
Human   669 RE-EEEMQRRRAKKLKRR 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5815	NP_733196.1	SPT2	<500..573	CDD:285455	39/76 (51%)
SPTY2D1	NP_919261.2	Important for interaction with DNA. /evidence=ECO:0000269\|PubMed:23378026	1..570		146/670 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..168		28/172 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..615		95/443 (21%)
		Important for interaction with histones. /evidence=ECO:0000269\|PubMed:23378026	571..685		56/124 (45%)
		SPT2	604..667	CDD:285455	35/64 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..685		18/41 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7360
eggNOG	1	0.900	-	-		E1_2C509
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4337
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007141
OrthoInspector	1	1.000	-	-		oto90150
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22691
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4767
SonicParanoid	1	1.000	-	-		X5240
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	10.040