DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH9 and CA8

DIOPT Version :9

Sequence 1:	NP_651535.1	Gene:	CAH9 / 43264	FlyBaseID:	FBgn0039486	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001308766.1	Gene:	CA8 / 767	HGNCID:	1382	Length:	290	Species:	Homo sapiens

Alignment Length:	274	Identity:	90/274 - (32%)
Similarity:	139/274 - (50%)	Gaps:	28/274 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FGYSEPNQRRWARHHGHCAGKTQSPIAITTSRTTAIHMPAVDM-IGYHNLLPYPLKMINNGHTVS 88
            :||.|..:  |........|:.||||.: .||........:|: :..:.::....::.|:|||:.
Human    29 WGYEEGVE--WGLVFPDANGEYQSPINL-NSREARYDPSLLDVRLSPNYVVCRDCEVTNDGHTIQ 90

  Fly    89 ITIPKVNVTEVGEDFLPYIRGAKLP--GEFEVEGLHFHWGDKNNRGSEHVINDIRYTMEMHIVHR 151
            :.:...:|          :.|..||  .|||:..:.||||.:|.|||||.:|...:.||:|::|.
Human    91 VILKSKSV----------LSGGPLPQGHEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHLIHW 145

  Fly   152 NKK-YATIGEALNHPDGAAVLGFFFNLDEDEGAGLVTINRHLHLIADANQEATLNVTFSLSSLIA 215
            |.. :.:|.||:..|.|.|::..|..:.: |..||..:...|..|....:..|: ..|:.::|:.
Human   146 NSTLFGSIDEAVGKPHGIAIIALFVQIGK-EHVGLKAVTEILQDIQYKGKSKTI-PCFNPNTLLP 208

  Fly   216 GVDVDKFYTYKGSLTTPPCSEAVTWILFPDPIPISPKQISRFR---------QLSDTQDGALVDN 271
            ...:..::.|:||||.|||||.||||||..|:.||..||..||         :|.:..||.|.||
Human   209 DPLLRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEGCDGILGDN 273

  Fly   272 FRTLQPVGNRRIFA 285
            ||..||:.:|.|.|
Human   274 FRPTQPLSDRVIRA 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH9	NP_651535.1	Carb_anhydrase	25..282	CDD:215000	87/269 (32%)
CA8	NP_001308766.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
CA8	NP_001308766.1	alpha_CARP_VIII	35..289	CDD:239394	87/268 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145696
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750