DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH9 and CAH5

DIOPT Version :9

Sequence 1:	NP_651535.1	Gene:	CAH9 / 43264	FlyBaseID:	FBgn0039486	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_001097988.2	Gene:	CAH5 / 50102	FlyBaseID:	FBgn0040629	Length:	302	Species:	Drosophila melanogaster

Alignment Length:	302	Identity:	111/302 - (36%)
Similarity:	158/302 - (52%)	Gaps:	37/302 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CWSQAVSSHVFGYSE-P-------NQRR-----------------WARHHGHC-AGKTQSPIAIT 53
            ||..|:....|.|.| |       .|.|                 |.   |.| :|:.||||.:.
  Fly     7 CWLLAICGCTFAYIEIPEAYLTAIRQDRADEQAAGEYNYDEQGDDWT---GTCQSGENQSPIDLI 68

  Fly    54 TSRTTAIHMPAVDMIGYHNLLPYPLKMINNGHTVSITIPKVNVTEVGEDFLPYIRGAKLPGEFEV 118
            ...:..:.:|.:....|...|..||.:.|||||.::.||:   |..|:  .|.|.|:.|||.||.
  Fly    69 FEDSKIVAIPRLRFNNYDQPLQTPLVITNNGHTANMVIPQ---TRGGQ--RPSINGSLLPGNFEA 128

  Fly   119 EGLHFHWGDKNNRGSEHVINDIRYTMEMHIVHRNKKYATIGEALNHPDGAAVLGFFFNLDEDEGA 183
            :.:|||||.:..:||||.||..||.:||||||:|..|.|:|||..||||.||||..|...:.:.:
  Fly   129 QSVHFHWGSREAKGSEHAINFQRYDVEMHIVHKNTIYETMGEATMHPDGLAVLGVMFRAVDRQTS 193

  Fly   184 ---GLVTINRHLHLIADANQEATLNVTFSLSSLIAGVDVDKFYTYKGSLTTPPCSEAVTWILFPD 245
               ||..|...|..|...|..||:....::..|:..:...:|:||.||||||.|:|||||.:|||
  Fly   194 QHYGLNKIFNQLPRIVQYNSNATITGRLTVGQLLGNIVTGEFFTYNGSLTTPDCAEAVTWTVFPD 258

  Fly   246 PIPISPKQISRFRQLSDTQDGALVDNFRTLQPVGNRRIFART 287
            .:....:||::...|.|::...|::|:|::|...:|.::.||
  Fly   259 VLDYPRRQITKLWNLRDSRQRPLINNYRSIQDTNSRDVYYRT 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH9	NP_651535.1	Carb_anhydrase	25..282	CDD:215000	105/285 (37%)
CAH5	NP_001097988.2	Carb_anhydrase	43..294	CDD:215000	99/258 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450180
Domainoid	1	1.000	91	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG3338
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I2251
Isobase	1	0.950	-	0	Normalized mean entropy	S5964
OMA	1	1.010	-	-		QHG27166
OrthoDB	1	1.010	-	-		D113047at6656
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm6335
orthoMCL	1	0.900	-	-		OOG6_100138
Panther	1	1.100	-	-	P	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
	13	12.760