DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH9 and CAH4

DIOPT Version :9

Sequence 1:	NP_651535.1	Gene:	CAH9 / 43264	FlyBaseID:	FBgn0039486	Length:	311	Species:	Drosophila melanogaster
Sequence 2:	NP_651298.1	Gene:	CAH4 / 42965	FlyBaseID:	FBgn0039235	Length:	279	Species:	Drosophila melanogaster

Alignment Length:	293	Identity:	104/293 - (35%)
Similarity:	155/293 - (52%)	Gaps:	34/293 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLEA-SFLLICWSQAVSSHVFGYSEPNQ-RRWARHHGHCAGKTQSPIAITTSRTTAIHMPAVDMI 68
            ||.| ||..|  :....|| ||::...| |.|   :..| |:.|||||:.:......::|.:..:
  Fly     2 FLVARSFAPI--NSGTRSH-FGFNYDKQGRDW---NVKC-GERQSPIALWSCNAITCNVPKLKFL 59

  Fly    69 GYHNLLPYPLKMINNGHTVSITIPKVNVTEVGEDFLPYIRGAK------LPGE--FEVEGLHFHW 125
            .||..|..||.:||||.||.:.|||.            :.|::      ..|:  ||.:.|||||
  Fly    60 NYHKSLCDPLSVINNGLTVLMRIPKT------------VDGSRPSLCISTEGQQVFEADQLHFHW 112

  Fly   126 GDKNNRGSEHVINDIRYTMEMHIVHRNKKYATIGEALNHPDGAAVLGFFFNLDED---EGAGLVT 187
            |...::||||.::...|..|:||||:|..|.:..||...|:|.|||..|....||   |...:..
  Fly   113 GSALSKGSEHCLDGNYYDGEVHIVHKNASYKSNKEAGLQPNGFAVLALFIRNLEDPNIETPAMNM 177

  Fly   188 INRHLHLIADANQEATLNVTFSLSSLIAGVDVDKFYTYKGSLTTPPCSEAVTWILFPDPIPISPK 252
            |.:.:..|...:....|..:.:|..|.|.:|..|::||:||||||||:|||.|.:||.|:.: ||
  Fly   178 ICKQVSSITKLDDSCPLEDSMALQDLFASIDSQKYFTYQGSLTTPPCAEAVIWFVFPTPLDV-PK 241

  Fly   253 QI-SRFRQLSDTQDGALVDNFRTLQPVGNRRIF 284
            :: ..|.||.|::|..:::.:|.||...:|.::
  Fly   242 ELWKHFWQLRDSRDQRVLNTYRELQDGHDRPVY 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH9	NP_651535.1	Carb_anhydrase	25..282	CDD:215000	95/269 (35%)
CAH4	NP_651298.1	alpha_CA	35..274	CDD:238200	90/251 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446778
Domainoid	1	1.000	91	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG3338
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I2251
Isobase	1	0.950	-	0	Normalized mean entropy	S5964
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113047at6656
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm6335
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
	11	10.850