DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eater and SCARF2

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_699165.3	Gene:	SCARF2 / 91179	HGNCID:	19869	Length:	871	Species:	Homo sapiens

Alignment Length:	519	Identity:	135/519 - (26%)
Similarity:	189/519 - (36%)	Gaps:	167/519 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 CDAP--EKCSCNDGYEMDGENRCSPVCSGG--C-KNGFCVAPGKCSCDEGYSKETGNSCKPICSK 432
            |.||  :..:|..|:...|:.....||.|.  | :|..||.||:|.|..||....       |..
Human    54 CRAPGSQVPTCCAGWRQQGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGAN-------CDT 111

  Fly   433 GCENGFC--DAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPI 495
            .|...|.  |..|.|||:.              .|.|::    ..|:|:|   :::..|..|:..
Human   112 KCPRQFWGPDCKELCSCHP--------------HGQCED----VTGQCTC---HARRWGARCEHA 155

  Fly   496 CSKGCENGFCDAPEKCSCNDGYEMDGENRCSP-----VCSGGCKNGFCVAPEKCS-------CDE 548
            |.  |::|.|. |...:|          ||.|     .|:..|   :|.|..:|.       |..
Human   156 CQ--CQHGTCH-PRSGAC----------RCEPGWWGAQCASAC---YCSATSRCDPQTGACLCHA 204

  Fly   549 GYSKETGNSCKPICSNGCENGFCDAPE-KCSCNDGYEMDGENRCSPVCSGGCKNGFC-VAPGKCS 611
            |:   .|.||...|:  |.:..|:... :|.|.   |.....||...|.  |..|.| ...|.|:
Human   205 GW---WGRSCNNQCA--CNSSPCEQQSGRCQCR---ERTFGARCDRYCQ--CFRGRCHPVDGTCA 259

  Fly   612 CDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCK--NGFCIAPG 674
            |:.||..:       .|.:.|..||            |.:....||     |.||  ....:|.|
Human   260 CEPGYRGK-------YCREPCPAGF------------YGLGCRRRC-----GQCKGQQPCTVAEG 300

  Fly   675 KC-SCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCV- 737
            :| :|:.|:     |..|  |.:.|..||..  |.||          :||.|     |::|...
Human   301 RCLTCEPGW-----NGTK--CDQPCATGFYG--EGCS----------HRCPP-----CRDGHACN 341

  Fly   738 -APGKCS-CDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDGENRCSPVCSGGCKNG 800
             ..|||: |:.|:   .|:.|:..||.|..                   ||: |:.||: .|.:|
Human   342 HVTGKCTRCNAGW---IGDRCETKCSNGTY-------------------GED-CAFVCA-DCGSG 382

  Fly   801 FC-IAPGKCSCDEGYSRETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGC 863
            .| ...|:|.|..|..   |..|...|..|...  .|..:.|||:       |:.|.|| :|.|
Human   383 HCDFQSGRCLCSPGVH---GPHCNVTCPPGLHG--ADCAQACSCH-------EDTCDPV-TGAC 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
eater	NP_651533.3	None
SCARF2	NP_699165.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PHA03247	<534..871	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900