Protein Alignment eater and MEGF10

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: XP_016865476.1
• Gene: MEGF10 / 84466
• HGNCID: 29634
• Length: 1195
• Species: Homo sapiens
• Alignment Length: 1030
• Identity: 260/1030 - (25%)
• Similarity: 364/1030 - (35%)
• Gaps: 354/1030 - (34%)

  Fly   124 CIPQCASGCPNGTCITPNNCSCNKGYKLNPTTQVC-----LPTCKDNCAAVNGFCAAP--NRCEC 181
            |:|.||..|.:|.||.||.|.|..|:.....:..|     .|.|...|...||....|  ..|.|
Human   160 CVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHC 224

  Fly   182 NPGFIPKPKSKSFECQPKCKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPD 246
            ..||      :.:.|:.:|:.|.....|.  .:|:                |:||....:.|..
Human   225 AAGF------RGWRCEDRCEQGTYGNDCH--QRCQ----------------CQNGATCDHVTGE- 264

  Fly   247 VCQCLTGYTKIGHNVCLAVCPEG-----------CQN-GVC-VAPNECSCNAGYTKLEGVCTPVC 298
             |:|..|||..   .|..:||.|           ||| ||| ....||||.:|:  :..||...|
Human   265 -CRCPPGYTGA---FCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGW--MGTVCGQPC 323

  Fly   299 KDGCVNGFCASPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYIKGTGNSCKPI 363
            .:|.....|:  ::|.|::|              |.|.    .|.|:|.|..||   ||..|:..
Human   324 PEGRFGKNCS--QECQCHNG--------------GTCD----AATGQCHCSPGY---TGERCQDE 365

  Fly   364 CSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKP 428
            |..|.....|  .|.|.|.:|              |.|.:    ..|.|.|:.|::   |..|:.
Human   366 CPVGTYGVLC--AETCQCVNG--------------GKCYH----VSGACLCEAGFA---GERCEA 407

  Fly   429 -ICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEG----YSKET 488
             :|.:|.....||  ::|.|:    :::.:.|.|:            .|:|:|..|    |..||
Human   408 RLCPEGLYGIKCD--KRCPCH----LENTHSCHPM------------SGECACKPGWSGLYCNET 454

  Fly   489 ------GNSCKPICSKGCENGF-CDA-PEKCSCNDGYE-MD----------GENRCSPVCSGGCK 534
                  |.:|:.|||  |:||. ||: ..||:|..|:: :|          |.| ||..|  |||
Human   455 CSPGFYGEACQQICS--CQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGIN-CSSRC--GCK 514

  Fly   535 NGFCVAP--EKCSCDEGYSKETGNSCKPICSNGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSG 597
            |....:|  ..|:|..|:.   |..|...|.:|.....|:.  .|.|.:|              |
Human   515 NDAVCSPVDGSCTCKAGWH---GVDCSIRCPSGTWGFGCNL--TCQCLNG--------------G 560

  Fly   598 GCKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCN--DGYEMDSENRCSPV 660
            .|.    ...|.|:|..|:   .|..|:..|..|.....|  .|:|.|:  ||        |.|
Human   561 ACN----TLDGTCTCAPGW---RGEKCELPCQDGTYGLNC--AERCDCSHADG--------CHP- 607

  Fly   661 CSGGCKNGFCIAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSP 725
                       ..|.|.|..|:|   |..|..:|::|.....|..|  |.|.:|..      |||
Human   608 -----------TTGHCRCLPGWS---GVHCDSVCAEGRWGPNCSLP--CYCKNGAS------CSP 650

  Fly   726 VCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDGENRCS 790
                        ..|.|.|..|:   .|.:|:.|||.|...                    :|||
Human   651 ------------DDGICECAPGF---RGTTCQRICSPGFYG--------------------HRCS 680

  Fly   791 PVC------SGGCKNGFCIAPGKCSCDEGYSRETGNSCKPICSKG-----------C-ENGFCDA 837
            ..|      ||.|.:    ..|.|.|..|:   ||..|..:|..|           | .||.|:.
Human   681 QTCPQCVHSSGPCHH----ITGLCDCLPGF---TGALCNEVCPSGRFGKNCAGICTCTNNGTCNP 738

  Fly   838 PEK-CSCNDGY-EMDSENRCSPVCSG-------GCKNG-FCVA-PGKCSCDEGYSKETEISCAPF 891
            .:: |.|..|: ..|....|.|...|       .|.|| ||.| .|:|.|..|:   |.:.|...
Human   739 IDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGW---TGLYCTQR 800

  Fly   892 CKDGCVNGLCVSPDFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRNGTCVEGICTCSKQYK 956
            |..|.....|..  .|:|.:|......|..|......:|.:  |::.|.:||...|
Human   801 CPLGFYGKDCAL--ICQCQNGADCDHISGQCTCRTGFMGRH--CEQKCPSGTYGYG--------- 852

  Fly   957 LHRNEDDNNLICLPICEPECL-NGLCE-FPGSCVC---WDGES---------------------- 994
                       |..||  :|| |..|: ..|:|.|   |.|..
Human   853 -----------CRQIC--DCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTAL 904

  Fly   995 PIDGYSCQSMDSLGSLTGHEKSERHLKWVFITIVSMAFILAIITTMLIIYIFRKR 1049
            |.|.|      .:|::.|          :.|.::.:.|:||    :.|||..:::
Human   905 PADSY------QIGAIAG----------IIILVLVVLFLLA----LFIIYRHKQK 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
MEGF10	XP_016865476.1	EMI	86..155	CDD:462204
		EGF_Lam	336..373	CDD:214543	16/57 (28%)
		EGF_CA	597..642	CDD:473889	18/69 (26%)