DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eater and MEGF11

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001371957.1	Gene:	MEGF11 / 84465	HGNCID:	29635	Length:	1140	Species:	Homo sapiens

Alignment Length:	1032	Identity:	259/1032 - (25%)
Similarity:	358/1032 - (34%)	Gaps:	334/1032 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 CIPQCASGCPNGTCITPNNCSCNKGYKLNPTTQVC-----LPTCKDNCAAVNGFCAAP--NRCEC 181
            |||.|...|.:|.|::|:.|.|..|:.....:..|     .|.|.:.|...||....|  ..|.|
Human    99 CIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVC 163

  Fly   182 NPGFIPKPKSKSFECQPKCKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPD 246
            ..||      :.:.|:..|..|.....|:.|  |:|..      ..:|.|            ...
Human   164 AAGF------RGWRCEELCAPGTHGKGCQLP--CQCRH------GASCDP------------RAG 202

  Fly   247 VCQCLTGYTKIGHNVCLAVCPEG-----------CQN-GVC-VAPNECSCNAGYTKLEGVCTPVC 298
            .|.|..|||.:   .|..:||.|           ||| |.| ....||:|..|:|  ..||...|
Human   203 ECLCAPGYTGV---YCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWT--GAVCAQPC 262

  Fly   299 KDGCVNGFCASPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYIKGTGNSCKPI 363
            ..|.....|:  :.|.|:.|              |.|.:    ..|:|.|..||:   |:.|:..
Human   263 PPGTFGQNCS--QDCPCHHG--------------GQCDH----VTGQCHCTAGYM---GDRCQEE 304

  Fly   364 CSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKP 428
            |..|.....|.  :.|.|::|      .:|||            ..|.|.|:.||.   |..|:.
Human   305 CPFGSFGFQCS--QHCDCHNG------GQCSP------------TTGACECEPGYK---GPRCQE 346

  Fly   429 -ICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSC 492
             :|.:|.....|..|  |.|    :.|:...|.||            .|.|:|..|:|   |:.|
Human   347 RLCPEGLHGPGCTLP--CPC----DADNTISCHPV------------TGACTCQPGWS---GHHC 390

  Fly   493 KPICSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPEKCSCDEGYSKETGNS 557
            ...|..|.....|..|  |:|.:|.:      |..:..|            |:|..|:   .|..
Human   391 NESCPVGYYGDGCQLP--CTCQNGAD------CHSITGG------------CTCAPGF---MGEV 432

  Fly   558 CKPICSNGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGN 622
            |...|:.|.....|.:  .||||:|      ..||||            .|.|:|.||:.   |.
Human   433 CAVSCAAGTYGPNCSS--ICSCNNG------GTCSPV------------DGSCTCKEGWQ---GL 474

  Fly   623 SCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCIAPGKCSCDEGYSKETG 687
            .|...|..|.....|:  |.|:|.:|      ..|||:            .|.|||..|:   .|
Human   475 DCTLPCPSGTWGLNCN--ESCTCANG------AACSPI------------DGSCSCTPGW---LG 516

  Fly   688 NSCKPICSKGCENGFCDAPEKCSCN--DGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSK 750
            ::|:..|..|.....|.  |.|.|:  ||        |.||            .|.|.|..|:
Human   517 DTCELPCPDGTFGLNCS--EHCDCSHADG--------CDPV------------TGHCCCLAGW-- 557

  Fly   751 ETGNSCKPICSKG-----------CENGFCEAPE--KCSCNDGYEMDGENRCSPVCSGGCKNGF- 801
             ||..|...|..|           ||||...:||  .|.|..|:.       .|:|...|..||
Human   558 -TGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFR-------GPLCQRICPPGFY 614

  Fly   802 ---CIAP---------------GKCSCDEGYSRETGNSCKPICSKGCENGFCDAPEKCSC-NDGY 847
               |..|               |.|.|..|:|   |..|..:|:.|....  |..:.||| |:|
Human   615 GHGCAQPCPLCVHSSRPCHHISGICECLPGFS---GALCNQVCAGGYFGQ--DCAQLCSCANNG- 673

  Fly   848 EMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGY-SKETEISCAP-------FCKDGCVNGL-CVS 903
                  .|||:            .|.|.|..|: .|:...:|.|       |....|.||. |.:
Human   674 ------TCSPI------------DGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSA 720

  Fly   904 PD-FCKCDDGYIFVEESKSCQLDKELLGDYSDCDK--NCRNG-TC--VEGICTCSKQYKLHRNED 962
            .| .|.|..|:..:..::.|  .....|  .||.:  .|:|| :|  :.|.|||...:.....|.
Human   721 EDGACHCTPGWTGLFCTQRC--PAAFFG--KDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQ 781

  Fly   963 DNNLICLP---------ICEPECL-NGLCE-FPGSCVCWDGESPIDGYSCQS----MDSLGSLTG 1012
            .    |.|         :|  ||: |..|: ..|:|.|..|   ..|..|..    |:.|...|.
Human   782 R----CAPGTFGYGCQQLC--ECMNNSTCDHVTGTCYCSPG---FKGIRCDQAALMMEELNPYTK 837

  Fly  1013 HEK---SERHLKWVFITIVSMAFILAIITTMLIIYIFRKRSYHVDKNEREFGVYFSP 1066
            ...   :|||...   .:..:..:|.:|..:|.::.:.:|      .::|.|...:|
Human   838 ISPALGAERHSVG---AVTGIMLLLFLIVVLLGLFAWHRR------RQKEKGRDLAP 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
MEGF11	NP_001371957.1	EMI	26..93	CDD:400092
		EGF_CA	275..320	CDD:419698	16/67 (24%)
		EGF_CA	362..409	CDD:419698	18/67 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810