Protein Alignment eater and Egfem1

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: XP_006535622.1
• Gene: Egfem1 / 75740
• MGIID: 1922990
• Length: 658
• Species: Mus musculus
• Alignment Length: 666
• Identity: 152/666 - (22%)
• Similarity: 227/666 - (34%)
• Gaps: 235/666 - (35%)

  Fly   234 ENGCVNG-----------NCTAPDVCQCLTGYTKIGHNVCLAVCPEG-----CQNGVCVAPNECS 282
            |.||.:.           .|:..|..|||              |.:|     ||..:    |||:
Mouse   145 EPGCFSSLSSLGTHFSGRECSYQDTRQCL--------------CSQGFHGPHCQYDI----NECA 191

  Fly   283 CNAGYTKLEGVCTPVCKDGCVNGFCASPEKCSCNDGYEMDSENR-------CSPVCSGGCKNGFC 340
            .:.|          .|:|.|.|  ......|.|..|.:::.:.|       |: |.:|||:.. |
Mouse   192 VDNG----------GCRDRCCN--TIGSYYCRCQAGQKLEEDGRGCEDVDECA-VVNGGCQQR-C 242

  Fly   341 V---APGKCSCDEGYIKGTGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCK 402
            :   ....|.||.||.:...       .:.|...|....:.|:        |.|.|:.:|.  .:
Mouse   243 INTLGTFHCECDTGYRRHAD-------ERTCIISFLSETDPCA--------GANGCAHLCQ--TE 290

  Fly   403 NGFCVAPGKCSCDEGYS-KETGNSCKPI---------CSKGCENGFCDAPEKCSCNDGYEMDSEN 457
            ||.    .:|:|..||. .|...:|:.|         |:..|.|.  .....|:|:.|:|:.::.
Mouse   291 NGM----ARCACHAGYQLSEDKKACEDINECAEELAPCAHHCVNS--KGSFTCTCHPGFELGADR 349

  Fly   458 R-C-------SPVC---SGGCKNGFC---VAPGKCSCDEGYSKET-GNSCKPICSKGCENGFCDA 507
            : |       ..:|   :|||.: .|   :....|||:.|:..:| |.:|  |....||:|
Mouse   350 KHCYRIELEIVNICEKNNGGCSH-HCEPAIGGAHCSCNHGHQLDTDGKTC--IDFDECESG---- 407

  Fly   508 PEKCSCNDGYEMDGENRCSPVC---SGGCKNGFCVAPEKCSCDEGYSKETGNSCKPICSNGCENG 569
             |.|             |:.:|   .||         .:|||:||:.         |.|:||.
Mouse   408 -EAC-------------CAQLCINYLGG---------YECSCEEGFQ---------ISSDGCG-- 438

  Fly   570 FCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKC-------------SCDEGYSKETG 621
             |||.::....:..|:|                ....||:.             |....|..|..
Mouse   439 -CDALDEQLEEEEEEID----------------ILRFPGRLAQNPPQPFPYLDPSLTASYEDEDN 486

  Fly   622 NSCKPICSKGCENGFCDAPEKCSCNDG-YEMDSENRCSPVCSGG-CKNG--FCIAPGKCS---CD 679
            :..... ::|...|. .|..:..|.|| :.:|....|....:|| |:.|  .|:.|.:.:   |:
Mouse   487 DDADSE-AEGEVQGL-TALYRVVCLDGTFGLDCSLSCEDCMNGGRCQEGKSGCLCPAEWTGLICN 549

  Fly   680 EGYSKETGNSCKPICSKGCENGFC--DAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKC 742
            |.....||...:  ...||..||.  :...||.|.:...              |...:    |.|
Mouse   550 ESSVLRTGEDQQ--APAGCLKGFFGKNCKRKCHCANNVH--------------CHRVY----GAC 594

  Fly   743 SCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCIAPGK 807
            .||.|   ..|..|...|.:|.....|..  :|.|.:      ||...  ||  .||      |.
Mouse   595 MCDLG---RYGRFCHLSCPRGAYGASCSL--ECQCVE------ENTLE--CS--AKN------GS 638

  Fly   808 CSCDEGYSRETGNSCK 823
            |:|..||.   ||.|:
Mouse   639 CTCKSGYQ---GNRCQ 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Egfem1	XP_006535622.1	FXa_inhibition	190..225	CDD:464251	10/46 (22%)
		FXa_inhibition	231..266	CDD:464251	11/43 (26%)
		vWFA	<268..310	CDD:469594	13/55 (24%)
		vWFA	<308..350	CDD:469594	9/43 (21%)
		FXa_inhibition	363..398	CDD:464251	11/35 (31%)
		vWFA	<395..436	CDD:469594	19/78 (24%)