DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eater and Egfem1

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	XP_006535622.1	Gene:	Egfem1 / 75740	MGIID:	1922990	Length:	658	Species:	Mus musculus

Alignment Length:	666	Identity:	152/666 - (22%)
Similarity:	227/666 - (34%)	Gaps:	235/666 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 ENGCVNG-----------NCTAPDVCQCLTGYTKIGHNVCLAVCPEG-----CQNGVCVAPNECS 282
            |.||.:.           .|:..|..|||              |.:|     ||..:    |||:
Mouse   145 EPGCFSSLSSLGTHFSGRECSYQDTRQCL--------------CSQGFHGPHCQYDI----NECA 191

  Fly   283 CNAGYTKLEGVCTPVCKDGCVNGFCASPEKCSCNDGYEMDSENR-------CSPVCSGGCKNGFC 340
            .:.|          .|:|.|.|  ......|.|..|.:::.:.|       |: |.:|||:.. |
Mouse   192 VDNG----------GCRDRCCN--TIGSYYCRCQAGQKLEEDGRGCEDVDECA-VVNGGCQQR-C 242

  Fly   341 V---APGKCSCDEGYIKGTGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCK 402
            :   ....|.||.||.:...       .:.|...|....:.|:        |.|.|:.:|.  .:
Mouse   243 INTLGTFHCECDTGYRRHAD-------ERTCIISFLSETDPCA--------GANGCAHLCQ--TE 290

  Fly   403 NGFCVAPGKCSCDEGYS-KETGNSCKPI---------CSKGCENGFCDAPEKCSCNDGYEMDSEN 457
            ||.    .:|:|..||. .|...:|:.|         |:..|.|.  .....|:|:.|:|:.::.
Mouse   291 NGM----ARCACHAGYQLSEDKKACEDINECAEELAPCAHHCVNS--KGSFTCTCHPGFELGADR 349

  Fly   458 R-C-------SPVC---SGGCKNGFC---VAPGKCSCDEGYSKET-GNSCKPICSKGCENGFCDA 507
            : |       ..:|   :|||.: .|   :....|||:.|:..:| |.:|  |....||:|
Mouse   350 KHCYRIELEIVNICEKNNGGCSH-HCEPAIGGAHCSCNHGHQLDTDGKTC--IDFDECESG---- 407

  Fly   508 PEKCSCNDGYEMDGENRCSPVC---SGGCKNGFCVAPEKCSCDEGYSKETGNSCKPICSNGCENG 569
             |.|             |:.:|   .||         .:|||:||:.         |.|:||.
Mouse   408 -EAC-------------CAQLCINYLGG---------YECSCEEGFQ---------ISSDGCG-- 438

  Fly   570 FCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKC-------------SCDEGYSKETG 621
             |||.::....:..|:|                ....||:.             |....|..|..
Mouse   439 -CDALDEQLEEEEEEID----------------ILRFPGRLAQNPPQPFPYLDPSLTASYEDEDN 486

  Fly   622 NSCKPICSKGCENGFCDAPEKCSCNDG-YEMDSENRCSPVCSGG-CKNG--FCIAPGKCS---CD 679
            :..... ::|...|. .|..:..|.|| :.:|....|....:|| |:.|  .|:.|.:.:   |:
Mouse   487 DDADSE-AEGEVQGL-TALYRVVCLDGTFGLDCSLSCEDCMNGGRCQEGKSGCLCPAEWTGLICN 549

  Fly   680 EGYSKETGNSCKPICSKGCENGFC--DAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKC 742
            |.....||...:  ...||..||.  :...||.|.:...              |...:    |.|
Mouse   550 ESSVLRTGEDQQ--APAGCLKGFFGKNCKRKCHCANNVH--------------CHRVY----GAC 594

  Fly   743 SCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCIAPGK 807
            .||.|   ..|..|...|.:|.....|..  :|.|.:      ||...  ||  .||      |.
Mouse   595 MCDLG---RYGRFCHLSCPRGAYGASCSL--ECQCVE------ENTLE--CS--AKN------GS 638

  Fly   808 CSCDEGYSRETGNSCK 823
            |:|..||.   ||.|:
Mouse   639 CTCKSGYQ---GNRCQ 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Egfem1	XP_006535622.1	EMI	71..140	CDD:369419
		FXa_inhibition	190..225	CDD:373209	10/46 (22%)
		vWFA	<213..265	CDD:381780	13/60 (22%)
		vWFA	<268..310	CDD:381780	13/55 (24%)
		vWFA	<308..350	CDD:381780	9/43 (21%)
		FXa_inhibition	363..398	CDD:373209	11/35 (31%)
		vWFA	<395..436	CDD:381780	19/78 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900