DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment eater and Megf10

DIOPT Version :9

Sequence 1:NP_651533.3 Gene:eater / 43262 FlyBaseID:FBgn0243514 Length:1074 Species:Drosophila melanogaster
Sequence 2:NP_001001979.1 Gene:Megf10 / 70417 MGIID:2685177 Length:1147 Species:Mus musculus


Alignment Length:1165 Identity:279/1165 - (23%)
Similarity:397/1165 - (34%) Gaps:411/1165 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 SLLLGLVSAQICTVNVTRNIKGTAVNVQTRDCCKGYKKVRSSALRCLAQCKVNCGSGFCTKPNVC 74
            |..|||:.:.:|      :..|||.::...|                              ||||
Mouse     6 SSCLGLICSLLC------HWVGTASSLNLED------------------------------PNVC 34

  Fly    75 --------TCKKGYVNLNNDPSNRCVPYCKGCSRGTCQSPGRCICSARHLLDKTT---------- 121
                    |.::.|.:    |.::.  |...|:  ...:..:|   .||.:...|          
Mouse    35 SHWESYSVTVQESYPH----PFDQI--YYTSCT--DILNWFKC---TRHRISYRTAYRHGEKTMY 88

  Fly   122 --------------NNCIPQCASGCPNGTCITPNNCSCNKGYKLNPTTQVC-----LPTCKDNCA 167
                          :.|:|.||..|.:|.||.||.|.|..|:.....:..|     .|.|...|.
Mouse    89 RRKSQCCPGFYESRDMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQ 153

  Fly   168 AVNGFCAAP--NRCECNPGFIPKPKSKSFECQPKCKNGCSNGVCRAPDKCECNKFYEKDIDGNCV 230
            ..|.....|  ..|.|..|:      :.:.|:.:|:.|.....|.  .:|:              
Mouse   154 CKNRALCNPITGACHCAAGY------RGWRCEDRCEQGTYGNDCH--QRCQ-------------- 196

  Fly   231 PICENGCVNGNCTAPDVCQCLTGYTKIGHNVCLAVCPEG-----------CQN-GVC-VAPNECS 282
              |:||....:.|..  |:|..|||..   .|..:||.|           ||| ||| ....|||
Mouse   197 --CQNGATCDHITGE--CRCSPGYTGA---FCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECS 254

  Fly   283 CNAGYTKLEGVCTPVCKDGCVNGFCASPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCS 347
            |.:|:  :..||...|.:|.....|:  ::|.|::|              |.|.    .|.|:|.
Mouse   255 CPSGW--MGTVCGQPCPEGRFGKNCS--QECQCHNG--------------GTCD----AATGQCH 297

  Fly   348 CDEGYIKGTGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKC 412
            |..||   ||..|:..|..|.....|  .|.|.|.:|              |.|.:    ..|.|
Mouse   298 CSPGY---TGERCQDECPVGSYGVRC--AEACRCVNG--------------GKCYH----VSGTC 339

  Fly   413 SCDEGYSKETGNSCKP-ICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPG 476
            .|:.|:|   |..|:. :|.:|.....||  ::|.|:    :|:.:.|.|:            .|
Mouse   340 LCEAGFS---GELCEARLCPEGLYGIKCD--KRCPCH----LDNTHSCHPM------------SG 383

  Fly   477 KCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDG-ENRCSPVCSGGCKNGFCVA 540
            :|.|..|:|   |..|...||.|.....|.  :.|||.:|.:.|. ..||:  |:.|.|...|..
Mouse   384 ECGCKPGWS---GLYCNETCSPGFYGEACQ--QICSCQNGADCDSVTGRCA--CAPGFKGTDCST 441

  Fly   541 PEKCSCDEGYSKETGNSCKPICSNGCENGFCDAP--EKCSCNDGYE-MDGENRCSPVCSGG---- 598
            |    |..|   ..|.:|...|  ||:|....:|  ..|.|..|:. :|    ||..|..|    
Mouse   442 P----CPLG---RYGINCSSRC--GCKNDAVCSPVDGSCICKAGWHGVD----CSIRCPSGTWGF 493

  Fly   599 -------CKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDG-YEMDSEN 655
                   |.||     |.|:..:|       :|  .|:.|.....|:.|    |.|| |.::...
Mouse   494 GCNLTCQCLNG-----GACNTLDG-------TC--TCAPGWRGAKCEFP----CQDGTYGLNCAE 540

  Fly   656 RCSPVCSGGCKNGFCIAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSE 720
            ||....:.||..    ..|.|.|..|:|   |..|..:|::|.....|..|  |.|.:|..    
Mouse   541 RCDCSHADGCHP----TTGHCRCLPGWS---GVHCDSVCAEGRWGPNCSLP--CYCKNGAS---- 592

  Fly   721 NRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDG 785
              |||            ..|.|.|..|:   .|.:|:.|||.|...                   
Mouse   593 --CSP------------DDGICECAPGF---RGTTCQRICSPGFYG------------------- 621

  Fly   786 ENRCSPVC------SGGCKNGFCIAPGKCSCDEGYSRETGNSCKPICSKG-----------C-EN 832
             :|||..|      ||.|.:    ..|.|.|..|:   ||..|..:|..|           | .|
Mouse   622 -HRCSQTCPQCVHSSGPCHH----ITGLCDCLPGF---TGALCNEVCPSGRFGKNCAGVCTCTNN 678

  Fly   833 GFCDAPEK-CSCNDGY-EMDSENRCSPVCSG-------GCKNG-FCVA-PGKCSCDEGYSKETEI 886
            |.|:..:: |.|..|: ..|....|.|...|       .|.|| ||.| .|:|.|..|:   |.:
Mouse   679 GTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGW---TGL 740

  Fly   887 SCAPFCKDGCVNGLCVSPDFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRNGTCVEGICTC 951
            .|...|..|.....|..  .|:|.:|......|..|......:|.:  |::.|..||...|    
Mouse   741 YCTQRCPLGFYGKDCAL--ICQCQNGADCDHISGQCTCRTGFMGRH--CEQKCPAGTYGYG---- 797

  Fly   952 SKQYKLHRNEDDNNLICLPICEPECL-NGLCE-FPGSCVC---WDGES----------------- 994
                            |..||  :|| |..|: ..|:|.|   |.|..                 
Mouse   798 ----------------CRQIC--DCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSR 844

  Fly   995 -----PIDGYSCQSMDSLGSLTGHEKSERHLKWVFITIVSMAFILAIITTMLIIYIFRKR 1049
                 |.|.|      .:|::.|          :.:.::.:.|:||    :.|||..:::
Mouse   845 TSTALPADSY------QIGAIAG----------IVVLVLVVLFLLA----LFIIYRHKQK 884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eaterNP_651533.3 None
Megf10NP_001001979.1 Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7 1..857 271/1122 (24%)
EMI 32..99 CDD:284877 12/77 (16%)
EGF_CA 281..326 CDD:304395 19/67 (28%)
EGF_CA 542..587 CDD:304395 15/53 (28%)
Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7 945..1147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1147
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1218
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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