DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eater and Megf11

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	XP_038938374.1	Gene:	Megf11 / 691517	RGDID:	1582797	Length:	1139	Species:	Rattus norvegicus

Alignment Length:	1031	Identity:	260/1031 - (25%)
Similarity:	363/1031 - (35%)	Gaps:	332/1031 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 CIPQCASGCPNGTCITPNNCSCNKGYKLNPTTQVC-----LPTCKDNCAAVNGFCAAP--NRCEC 181
            |||.|...|.:|.|::|:.|.|..|:.....:..|     .|.|.:.|...||....|  ..|.|
  Rat    99 CIPLCTEECMHGRCVSPDTCHCEPGWGGPDCSSGCDSEHWGPHCSNRCQCQNGALCNPITGACVC 163

  Fly   182 NPGFIPKPKSKSFECQPKCKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPD 246
            .|||      :.:.|:..|..|.....|:.  .|:|:.      ..:|.|            ...
  Rat   164 APGF------RGWRCEEFCAPGTHGKGCQL--LCQCHH------GASCDP------------RTG 202

  Fly   247 VCQCLTGYTKIGHNVCLAVCPEG-----------CQN-GVC-VAPNECSCNAGYTKLEGVCTPVC 298
            .|.|..|||.:   .|..:||.|           ||| |.| ....||:|..|:|  ..||...|
  Rat   203 ECLCAPGYTGV---YCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWT--GAVCAQPC 262

  Fly   299 KDGCVNGFCASPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYIKGTGNSCKPI 363
            ..|.....|:  :.|.|:.|              |.|.:    ..|:|.|..||:   |:.|:..
  Rat   263 PPGTFGQNCS--QDCPCHHG--------------GQCDH----VTGQCHCTAGYM---GDRCQEE 304

  Fly   364 CSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKP 428
            |..|.....|.  ::|.|::|      .:|||            |.|.|.|:.||.   |.||:.
  Rat   305 CPFGTFGFRCS--QRCDCHNG------GQCSP------------ATGACECEPGYK---GPSCQE 346

  Fly   429 -ICSKGCENGFCDAPEKCSCNDGYEMDSEN--RCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGN 490
             :|.:|.....|.:|  |.|      |:||  .|.||            .|.|:|..|:|   |:
  Rat   347 RLCPEGLHGPGCTSP--CPC------DTENTISCHPV------------TGACTCQPGWS---GH 388

  Fly   491 SCKPICSKGCENGFCDAPEKCSCNDG---YEMDGENRCSPVCSGGCKNGFCVAPEKCSCDEGYSK 552
            .|...|..|.....|..|  |:|.:|   :.:.|...|:|    |.....|..|    |..|
  Rat   389 YCNESCPAGYYGNGCQLP--CTCQNGADCHSITGSCTCAP----GFMGEVCAVP----CAAG--- 440

  Fly   553 ETGNSCKPICSNGCENGFCDAP--EKCSCNDGYE-MDGENRCSPVCSGG-----------CKNGF 603
            ..|.:|..:||  |.||...:|  ..|:|.:|:: :|    ||..|..|           |.||.
  Rat   441 TYGPNCSSVCS--CSNGGTCSPVDGSCTCREGWQGLD----CSLPCPSGTWGLNCNESCVCANGA 499

  Fly   604 CVAP--GKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCN--DGYEMDSENRCSPVCSGG 664
            ..:|  |.|:|..|:   .|:||:..|..|.....|.  |.|.|:  ||        |.||
  Rat   500 ACSPFDGSCACTPGW---LGDSCELPCPDGTFGLNCS--EHCDCSHADG--------CDPV---- 547

  Fly   665 CKNGFCIAPGKCSCDEGYSKETGNSCKPICSKG-----------CENGFCDAP--EKCSCNDGYE 716
                    .|.|.|..|:   ||..|...|..|           ||||...:|  ..|.|..|:.
  Rat   548 --------TGHCCCLAGW---TGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPVDGSCECAPGFR 601

  Fly   717 MDSENRCSPVCSGGCKNGF----CVAP---------------GKCSCDEGYSKETGNSCKPICSK 762
                   .|:|...|..||    |..|               |.|.|..|:|   |..|..:|:.
  Rat   602 -------GPLCQRICPPGFYGHGCAQPCPLCVHSRGPCHHVSGICECLPGFS---GALCNQVCAG 656

  Fly   763 GCENGFCEAPEKCSC-NDGYEMDGENRCSPVCSGGCKNGFCIAPGKCSCDEGYSRETGNSCKPIC 826
            |.....|  .:.||| |:|       .|||:            .|.|.|..|:   ||..    |
  Rat   657 GHFGQDC--AQLCSCANNG-------TCSPI------------DGSCQCFPGW---TGKD----C 693

  Fly   827 SKGCENGFCDAP--EKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETEISCA 889
            |:.|.:||..:.  ..|||::|....:|:                  |.|.|..|:   |.:.|.
  Rat   694 SQACPSGFWGSACFHTCSCHNGASCSAED------------------GACHCTPGW---TGLFCT 737

  Fly   890 PFCKDGCVNGLCVSPDFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRNGTCVEGICTCSKQ 954
            ..|........|  ...|:|.:|......:..|.......|.:  |::.|..||...|
  Rat   738 QRCPAAFFGKDC--GHICQCQNGASCDHITGKCTCRTGFSGRH--CEQRCAPGTFGYG------- 791

  Fly   955 YKLHRNEDDNNLICLPICEPECL-NGLCE-FPGSCVCWDGESPIDGYSCQS----MDSLGSLTGH 1013
                         |..:|  ||: |..|: ..|:|.|..|   ..|..|..    ||.|...|..
  Rat   792 -------------CQQLC--ECMNNATCDHVTGTCYCSPG---FKGIRCDQAALMMDELNPYTKI 838

  Fly  1014 EK---SERHLKWVFITIVSMAFILAIITTMLIIYIFRKRSYHVDKNEREFGVYFSP 1066
            ..   :|||.......|:.:.|::.:   :|.::.:|:|      .::|.|...:|
  Rat   839 SPALGAERHSVGAVTGIILLLFLVVV---LLGLFAWRRR------RQKEKGRDLAP 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Megf11	XP_038938374.1	EMI	26..93	CDD:400092
		EGF_CA	189..234	CDD:419698	13/65 (20%)
		Laminin_EGF	275..320	CDD:395007	16/67 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910