DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and Megf6

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_075244.1	Gene:	Megf6 / 65049	RGDID:	621188	Length:	1574	Species:	Rattus norvegicus

Alignment Length:	1416	Identity:	352/1416 - (24%)
Similarity:	457/1416 - (32%)	Gaps:	527/1416 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RNIKGTAVNVQTRDCCKGYKKVRSSALRCLAQCKVNCGS--GFCTKP--NV-----CTCKKGYVN 82
            |.:..|......| ||.|:.: :.....||:... .|.|  |.|..|  |.     |.|..|| .
  Rat    94 RQVYATEARTVFR-CCPGWSQ-KPGQEGCLSDVD-ECASANGGCEGPCCNTVGGFYCRCPPGY-Q 154

  Fly    83 LNNDPS-----NRCVPYCKGCSRGTCQSPGRCICSAR-----HLLDKTTNNCIPQCASGCPNGTC 137
            |..|..     :.|..:..||......:||..:|..:     | .|..|...|..|..|  ||.|
  Rat   155 LQGDGKTCQDVDECRAHNGGCQHRCVNTPGSYLCECKPGFRLH-TDGRTCLAISSCTLG--NGGC 216

  Fly   138 --------ITPNNCSCNKGYKLNPTTQVCLPTCKDNCAAVNGFC-------AAPNRCECNPGFIP 187
                    :|.:.|.|...|:|....:.|:.  :..||..||.|       .....|.|:||:..
  Rat   217 QHQCVQLTVTQHRCQCRPQYQLQEDGRRCVR--RSPCAEGNGGCMHICQELRGLAHCGCHPGYQL 279

  Fly   188 KPKSKSF----ECQ---PKCKNGCSNGVCRAPDKCECNKFYEKDIDG-NCVPI-------CENGC 237
            ....|:.    ||.   .:|.:||.|  .:...||.|:..||...|| .|..|       ||.|
  Rat   280 AADRKTCEDVDECALGLAQCAHGCLN--TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEAG- 341

  Fly   238 VNGNC--------TAPDVCQCLTGY-------TKIGHNVCL--AVCPEGCQNGVCVAPN--ECSC 283
             ||.|        |.| :|.|..||       |.|..:.|.  ..|.:.|.|    .|.  ||||
  Rat   342 -NGGCSHGCSHTSTGP-LCTCPRGYELDEDQKTCIDIDDCANSPCCQQACAN----TPGGYECSC 400

  Fly   284 NAGY-TKLEGV-CTPV---------CKDGCVNGFCASPEKCSCNDGYEMDSENR----------- 326
            .||| ...:|. |..|         |:..|.|  .|...:|.|..||.:|.:.|
  Rat   401 FAGYRLNTDGCGCEDVDECASGHGGCEHHCSN--LAGSFQCFCEAGYRLDEDRRGCTSLEESVVD 463

  Fly   327 ------------------------------------------------------------CSPVC 331
                                                                        ||..|
  Rat   464 LDGRLPFVRPLPHIAVLRDELPRLFQDDYGAEEEAAAAELRGEHTLTEKFVCLDHSFGHDCSLTC 528

  Fly   332 SGGCKNGFCVAPGK--CSCDEGYIKGTGNSCKPICSKGCENGFCDAPEKCSCNDGYEMD---GEN 391
            . .|:||....||:  |.|.||:   ||..|...|........|.:|  |:|.:|...|   |..
  Rat   529 D-DCRNGGTCFPGQDGCDCPEGW---TGIICNETCPPDTFGKNCSSP--CTCQNGGTCDPVLGAC 587

  Fly   392 RCSPVCSG-----GCKNGF----------CVAPGKCS-------CDEGY---------------- 418
            ||.|..||     ||..||          |...|:|.       ||.|.
  Rat   588 RCPPGVSGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGP 652

  Fly   419 -----------------SKETGNSCK-----PICSKGCENGF----CDAPEKCSCNDGYEMD--- 454
                             .|:...|||     ..|...||:||    |  ..:|:|..|...|
  Rat   653 GCSEDCLCEQSHTRSCNPKDGSCSCKAGFQGERCQAECESGFFGPGC--RHRCTCQPGVACDPVS 715

  Fly   455 --SENRCSP------------------VCSGGCKNGFCV-AP-----GKCSCDEGYSKETGNSCK 493
              ...:|.|                  .|||.|.   || ||     |:|.|..|   :||..|.
  Rat   716 GECRTQCPPGYQGEDCGQECPVGTFGVNCSGSCS---CVGAPCHRVTGECLCPPG---KTGEDCG 774

  Fly   494 PICSKG------------CENGFCDAPE--KCSCNDGYEMDGENRCSPVCSGG-----------C 533
            ..|.:|            ||:|....||  .|.|..|:.   .:||...||.|           |
  Rat   775 ADCPEGRWGLGCQEICPACEHGASCNPETGTCLCLPGFV---GSRCQDTCSAGWYGTGCQIRCAC 836

  Fly   534 KN-GFC-VAPEKCSCDEGYSKETGNSCKPICSNG-----------CE--NGFCDAPE-KCSCNDG 582
            .| |.| ....:|||..|:   ||.||:..|.:|           |.  :|.|||.. .|.|..|
  Rat   837 ANDGHCDPTTGRCSCAPGW---TGLSCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSGLCLCEAG 898

  Fly   583 YEMDGENRCSPVCSGGCKNGFCVAPG---KCSCDEGYS-KETGNSCK-------PICSKGCENGF 636
            ||       .|.|...|:.|: ..|.   ||.|:.|.: .....:|.       ..|...|..||
  Rat   899 YE-------GPRCEQSCRQGY-YGPSCEQKCRCEHGAACDHVSGACTCPAGWRGSFCEHACPAGF 955

  Fly   637 ----CDAPEKCSCNDGYEMDSEN-------------------------RCSPVCSGGCKNGFCI- 671
                ||:  .|:|:.|...|:..                         .||.:|:  |.||...
  Rat   956 FGLDCDS--ACNCSAGAPCDAVTGSCICPAGRWGPRCAQSCPPLTFGLNCSQICT--CFNGASCD 1016

  Fly   672 -APGKCSCDEGYSKET----------GNSCKPICSKGCEN-GFCDAP--EKCSCNDGYE-MDSEN 721
             ..|:|.|..|:...|          |.:|:..|.  |.| |.|| |  .:|:|.:|:. :..||
  Rat  1017 SVTGQCHCAPGWMGPTCLQACPPGLYGKNCQHSCL--CRNGGRCD-PILGQCTCPEGWTGLACEN 1078

  Fly   722 RCSP-VCSGGCK-------NGFC-VAPGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSC 777
            .|.| ..:.||:       .|.| ...|.|.|..|:   ||:.|:..|..|.....||  |.|:|
  Rat  1079 ECLPGHYAAGCQLNCSCLHGGICDRLTGHCLCPAGW---TGDKCQSSCVSGTFGVHCE--EHCAC 1138

  Fly   778 NDG---YEMDGENRC-----SPVCSGGCKNGF--------CIAP---------GKCSCDEGYSRE 817
            ..|   :.:.|...|     .|.|...|..|:        |:.|         |:|.|..|:
  Rat  1139 RKGASCHHVTGACFCPPGWRGPHCEQACPRGWFGEACAQRCLCPTNASCHHVTGECRCPPGF--- 1200

  Fly   818 TGNSCKPICSKG-----CENGFCDAPEK----------CSCNDGY------EMDSENRCSPVCSG 861
            ||.||:..|..|     ||: .|..|.:          |:|..||      :.....|..|.|..
  Rat  1201 TGLSCEQACQPGTFGKDCEH-LCQCPGETWACDPASGVCTCAAGYHGTGCLQRCPSGRYGPGCEH 1264

  Fly   862 GCK---NGFC-VAPGKCSCDEGY-SKETEISC-----APFCKDGC----------VNGLCVSPDF 906
            .||   .|.| .|.|.|.|..|: ..:..::|     .|.|...|          |:|.|:
  Rat  1265 ICKCLNGGTCDPATGACYCPAGFLGADCSLACPQGRFGPSCAHVCACRQGAACDPVSGACI---- 1325

  Fly   907 CKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRN-GTC--VEGICTCSKQYKLHRNEDDNNLIC 968
              |..|...|.....|..|:  .|...:....||| |.|  ..|.|:|...:            .
  Rat  1326 --CSPGKTGVRCEHGCPQDR--FGKGCELKCACRNGGLCHATNGSCSCPLGW------------M 1374

  Fly   969 LPICEPEC----------------LNGLCE-FPGSCVCWDGESPIDGYSCQ 1002
            .|.||..|                .||.|| ..|:|:|..|   ..|.:|:
  Rat  1375 GPHCEHACPAGRYGAACLLECFCQNNGSCEPTTGACLCGPG---FYGQACE 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Megf6	NP_075244.1	EMI	42..112	CDD:284877	6/18 (33%)
		FXa_inhibition	127..162	CDD:291342	12/35 (34%)
		vWFA	<154..202	CDD:294047	10/48 (21%)
		vWFA	<237..285	CDD:294047	11/49 (22%)
		vWFA	<284..325	CDD:294047	13/42 (31%)
		FXa_inhibition	338..373	CDD:291342	12/37 (32%)
		vWFA	<371..410	CDD:294047	14/42 (33%)
		vWFA	<413..452	CDD:294047	11/40 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900