DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and megf6a

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	XP_017209228.2	Gene:	megf6a / 565108	ZFINID:	ZDB-GENE-090312-12	Length:	1513	Species:	Danio rerio

Alignment Length:	1504	Identity:	364/1504 - (24%)
Similarity:	480/1504 - (31%)	Gaps:	643/1504 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VQTR-----DCCKGYKKVRSSALRCLA--QCKVNCGSGFCTKPNV--------CTCKKGYVNLNN 85
            |.||     :|..|: ::......|:|  .|.||  :|.|....|        |.|::|| .|..
Zfish   127 VNTRGSYYCECNPGF-RLHVDGRTCIAVLSCSVN--NGGCEHECVQLSPVHFQCRCRRGY-QLTA 187

  Fly    86 DPS-----NRCVPYCKGCSRGTCQSP-GRCICSARH----LLDKTT----NNC---IPQCASGCP 133
            |..     |.||....||.. .|:|. ||.:||...    .:|:.:    |.|   :..||..|.
Zfish   188 DGKRCRLRNPCVEKNGGCVH-LCRSDGGRVVCSCHQGFMLAVDQKSCEDVNECETGLAACAHSCR 251

  Fly   134 NGTCITPN--NCSCNKGYKLNPTTQVC-------LPTCKDNCAAVNGFCAAPNRCE--------- 180
            |    ||.  :|.||.||:|....:.|       :.||..:    ||.|:  :||:
Zfish   252 N----TPGSFSCICNPGYELGSDGRKCYRIEMEIVNTCDSD----NGGCS--HRCQHGVLGPVCS 306

  Fly   181 CNPGFIPKPKSKSF----ECQPK---CKNGCSN------GVCRA-----PDKCECNKFYEKDID- 226
            ||.|:......|:.    ||:..   |:..|:|      ..|||     .|.|.|:     |:|
Zfish   307 CNHGYQLAEDLKTCLDLEECEEGTSCCEQDCTNYPGGYECYCRAGYRLNADGCGCD-----DVDE 366

  Fly   227 -----GNCVPICENG-------------------------------------------------- 236
                 |.|...|:|.
Zfish   367 CASDRGGCEHTCQNTAGSYHCFCRFGYRLGEDRHSCISLQRSVEELPGPVVVERPLLHLALLQDY 431

  Fly   237 -----------------------------CVNGN-----------------CTAP-DVCQCLTGY 254
                                         |:||.                 |.|. |.|.|..|:
Zfish   432 PQPLERYHDYEEDSFGELRAESTFAEKFVCLNGTFGHDCSLTCDDCSNGGYCNAEGDACDCPDGW 496

  Fly   255 TKIGHNVCLAVCPEG-----------CQNGVCVAP--NECSCNAGYTKLEGVCTPVCKDGCVNGF 306
            |.|   :|...||||           |:||....|  .:|.|.      .||...:|:|||..|.
Zfish   497 TGI---LCNQTCPEGTFGKNCSFTCKCRNGGTCDPISGKCRCP------PGVNGDLCQDGCPKGM 552

  Fly   307 CAS--PEKCSC-NDGYEMDSENRC-----SPVCSGGCKNGFCVAP-------------------- 343
            ...  .:||:| |:|       ||     :.:|..|....||..|
Zfish   553 YGKHCNKKCNCANNG-------RCHRTYGACLCDPGLYGRFCHLPCPKWSYGSGCSSECQCVQQN 610

  Fly   344 --------GKCSCDEGYIKGTGNSCKPICSKGCENGF--------CDAPEKCSCNDGYEMDGENR 392
                    |.|.|..||...|       |::.|::||        |..|...||   :.|.|:
Zfish   611 TLECHRRHGTCVCKPGYQGKT-------CNRECDSGFYGPGCRLKCQCPAGVSC---HPMSGQ-- 663

  Fly   393 CSPVCSGG------------------------CKNGFC-VAPGKCSCDEGYSKETGNSCKPICSK 432
            |...|..|                        ||...| ...|||.|..|   :||..|:..|.:
Zfish   664 CQRQCPAGLHGEHCDRECPMGQFGVGCTQFCDCKGAPCNSVTGKCHCPAG---QTGQHCEKECEE 725

  Fly   433 G------------CEN-GFCDAPE-KCSCNDGYEMDSENRCSPVCSGG-----------CKN-GF 471
            |            |:| |.||... .|.|:.|:   ..|.|..||..|           |:| |.
Zfish   726 GRWGLGCAESCPSCDNGGVCDRQNGTCVCSPGF---MGNLCQNVCPDGHFGLSCLLRCSCQNEGK 787

  Fly   472 C-VAPGKCSCDEGYSKETGNSCKPICSKG-----CEN--------GFCD-APEKCSCNDGYEMDG 521
            | ...|.|.|.:|:   .|.:|...|..|     |.|        |.|| ....|.|..||
Zfish   788 CHHVTGLCVCKDGW---MGPNCAKACVAGRWGPNCANQCDCRSSVGSCDPVIGLCHCEAGY---- 845

  Fly   522 ENRCSPVCSGGCKNGF----CVAPEKCSCDEGYSKE------------TGNSCKPICSNGCENGF 570
               ..|.|...|..||    |  ..:|.|:.|...|            ||..|:..|..|.....
Zfish   846 ---MGPRCDQKCPQGFFGQSC--QHRCQCENGAVCEHVSGACTCLAGWTGTYCEKPCPEGFHGLE 905

  Fly   571 CDAPEKCSCNDG---YEMDGENRC-----SPVCSGGCK----------------NGFC-VAPGKC 610
            |.  :||.|.:|   :.:.|..:|     .|||:..|:                ||.| .|.|:|
Zfish   906 CQ--QKCQCLNGGRCHPVTGGCQCPSGWVGPVCNATCEAGTFGPACSQTCRCHNNGTCDPADGRC 968

  Fly   611 SCDEGYSKETGNSCKPICSKG-----------CEN-GFCD-APEKCSCNDG-------------- 648
            .|..|:   ||:||:..||.|           |:| |.|| ....|:|..|
Zfish   969 ECGAGW---TGSSCEQECSAGLYGVGCNQHCLCQNGGSCDRISGHCTCVSGWTGVACELECAAGH 1030

  Fly   649 YEMDSENRCSPVCSGGCKNGFCIAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCND 713
            :.||.:::|..|..|.|..    ..|:|.|..|:   ||..|:..|::|.....|  .|:|.|:.
Zfish  1031 FGMDCQHKCECVNGGVCDR----HSGRCLCPAGW---TGTHCETACTQGFYGPGC--KERCRCDH 1086

  Fly   714 ---------------GYEMDSENRCSPVCSGG-----CKNGFCVAP---------GKCSCDEGYS 749
                           |:.   ...|..||..|     |.:. |..|         |:|.|..|.
Zfish  1087 NAACHHITGTCLCPAGWR---GTHCEKVCLPGSYGKRCAHR-CQCPHGTSCNHVTGQCGCPAGL- 1146

  Fly   750 KETGNSCKPICSKG-----CENGFCEAPE----------KCSCNDGY-----EMDGE-NRCSPVC 793
              ||:.|:.:|..|     | |..|:..|          .|.|..||     |.:.| .|..|.|
Zfish  1147 --TGSGCERMCQSGTFGVNC-NQVCQCSELNQLCHPVTGVCYCAPGYYGSKCETECEAGRYGPNC 1208

  Fly   794 SGGCK---NGFC-IAPGKCSCDEGYSRETGNSCKPICSKG-----------CENGFCDAP--EKC 841
            ...|:   ||.| .:.|.|||..|:   .|.:|...|..|           |..|....|  .:|
Zfish  1209 EQECQCLNNGVCKSSTGTCSCPPGF---IGPNCNITCPLGRYGQDCAGVSLCGEGARSDPLTGRC 1270

  Fly   842 SCNDG--------------YEMDSENRCSPVCSGGCKNGFCVA-PGKCSCDEGYSKETEISCAPF 891
            .|..|              :..:.:.||:  ||.|   |.|.| .|.|||..|::.:|   |...
Zfish  1271 VCRAGQRGRDCGKGCAEGWFGENCDQRCN--CSNG---GVCDALTGHCSCTLGWTGDT---CEEV 1327

  Fly   892 CKDG-----------------C--VNGLCV-SPDF----CK--CDDGYIFVEESKSCQLDKELLG 930
            |..|                 |  |.|:|: ||.|    |:  |..|:    ....|||
Zfish  1328 CPRGRYGSDCSEVCDCKNNSTCDRVTGVCLCSPGFYGHLCQHACPVGF----HGHRCQL------ 1382

  Fly   931 DYSDCDKN--CRNGTCVEGICTCSKQYK-----------------LHRNEDDNNLICLPI----- 971
             ..||..|  |...|   |.|.|...|:                 :||.:.|.:..|.||
Zfish  1383 -LCDCGANAPCDPET---GRCLCPAGYQGLRCERECELGTFGADCVHRCDCDGDTPCDPINGRCL 1443

  Fly   972 CEP------------------------ECLN-GLCEFP--GSCVCWDGESPIDGYSCQSMDSLGS 1009
            |.|                        |||| |.|: |  |.|.|.:|..   |.|||.     .
Zfish  1444 CAPGKTGSRCDIGCGVNRFGPDCSQRCECLNGGQCD-PRNGRCTCLNGWI---GPSCQQ-----G 1499

  Fly  1010 LTGHEKSER 1018
            |....||:|
Zfish  1500 LLSASKSKR 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
megf6a	XP_017209228.2	EMI	31..100	CDD:311482
		FXa_inhibition	115..150	CDD:317114	5/23 (22%)
		FXa_inhibition	156..192	CDD:317114	12/38 (32%)
		FXa_inhibition	198..233	CDD:317114	11/35 (31%)
		vWFA	<233..272	CDD:320736	14/42 (33%)
		FXa_inhibition	285..320	CDD:317114	10/40 (25%)
		vWFA	<312..358	CDD:320736	9/45 (20%)
		FXa_inhibition	367..402	CDD:317114	4/34 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	227	1.000	Inparanoid score	I3454
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050