DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and STAB2

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_060034.9	Gene:	STAB2 / 55576	HGNCID:	18629	Length:	2551	Species:	Homo sapiens

Alignment Length:	1714	Identity:	325/1714 - (18%)
Similarity:	462/1714 - (26%)	Gaps:	874/1714 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IYSLLLGLVS---AQICTVNVTRNIKGTAVNVQTRDCCKGYKKVRSSALRCLAQCKVNC-GSGFC 68
            :||...|.:.   |:.|  |.|         |:...||||:  ......:|.......| |:|.|
Human   703 VYSGRFGSLKSGCARYC--NAT---------VKIPKCCKGF--YGPDCNQCPGGFSNPCSGNGQC 754

  Fly    69 TKP----NVCTCKKGY----VNLNNDPSN---RCVPYCKGCSRGTC----QSPGRCI---C---S 112
            ...    ..|.|::|:    ....:||:.   ||...|. |..|||    .|.|.|:   |   |
Human   755 ADSLGGNGTCICEEGFQGSQCQFCSDPNKYGPRCNKKCL-CVHGTCNNRIDSDGACLTGTCRDGS 818

  Fly   113 ARHLLDKTTNNCIPQCASGCPNGTCITPN---NCSCNKGY--------KLNPTTQV--------- 157
            |..|.||.|:.|.|.......:.||...|   :|.|..||        :::|.|.:
Human   819 AGRLCDKQTSACGPYVQFCHIHATCEYSNGTASCICKAGYEGDGTLCSEMDPCTGLTPGGCSRNA 883

  Fly   158 -CLPT--------CKD-------NCAAVNGFCAAP------------------NRCECNPGFIPK 188
             |:.|        |:.       :|:.:|. |..|                  |.|||..||
Human   884 ECIKTGTGTHTCVCQQGWTGNGRDCSEINN-CLLPSAGGCHDNASCLYVGPGQNECECKKGF--- 944

  Fly   189 PKSKSFECQP---------KCK-----NGCSNGVCRAPDKCECNKFYEKD--------------- 224
             :....:|:|         ||.     ...|:||.    .|.|.:.||.|
Human   945 -RGNGIDCEPITSCLEQTGKCHPLASCQSTSSGVW----SCVCQEGYEGDGFLCYGNAAVELSFL 1004

  Fly   225 ----------------------------------------------------------------- 224

Human  1005 SEAAIFNRWINNASLQPTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPALIKYHMLLGTY 1069

  Fly   225 -----------------IDGNCVPICENGCVNGNCT----------------------------- 243
                             :.||.:.:.:   |:||.|
Human  1070 RVADLQTLSSSDMLATSLQGNFLHLAK---VDGNITIEGASIVDGDNAATNGVIHIINKVLVPQR 1131

  Fly   244 ---------------APDVCQCLTGYTKIGHNVCLAVCPEGCQNGVCVAPNECSCNA--GYTKLE 291
                           .||. ....||. |.:|:..|:  |........|||.   ||  .|.:.:
Human  1132 RLTGSLPNLLMRLEQMPDY-SIFRGYI-IQYNLANAI--EAADAYTVFAPNN---NAIENYIREK 1189

  Fly   292 GVCT--------------PVCKDGCVNG--------------FCASPEKCSCND----------- 317
            .|.:              .:.|:...||              |....::...|:
Human  1190 KVLSLEEDVLRYHVVLEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATD 1254

  Fly   318 -------GYEMD-SENRCSPVCSGGCKNGFCVAPGKC-------SCDEGYIKGTGN--------- 358
                   |..:: .:|||.       .|...:..|:|       :|..| .|..||
Human  1255 KGVIHGLGKVLEIQKNRCD-------NNDTTIIRGRCRTCSSELTCPFG-TKSLGNEKRRCIYTS 1311

  Fly   359 ----------SCKPIC-----SKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCK-----N 403
                      .|:|.|     ::.|..||. .|:               |.| |.|..:     |
Human  1312 YFMGRRTLFIGCQPKCVRTVITRECCAGFF-GPQ---------------CQP-CPGNAQNVCFGN 1359

  Fly   404 GFCV----APGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCS 464
            |.|:    ..|.|.|.||:|   |.:|: .|::|.....||  :.|||..|       ||
Human  1360 GICLDGVNGTGVCECGEGFS---GTACE-TCTEGKYGIHCD--QACSCVHG-------RC----- 1406

  Fly   465 GGCKNGFCVAPGKCSCDEGY------SKETGNSCKPIC--SKGCENGFCDAPEKCSCNDGYEMDG 521
                |...:..|.|.||.|:      :..|.::|...|  |..|... .|....|.|..|::.:|
Human  1407 ----NQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTN-SDGTASCKCAAGFQGNG 1466

  Fly   522 E-----NRCSPVCSGGCK-NGFC--VAPEK--CSCDEGYSKETGNSCKPICSNGC-EN-GFCD-- 572
            .     |.|. :.:|||. ...|  ..|.:  |:|..||:.: |..|..|  |.| || |.||
Human  1467 TICTAINACE-ISNGGCSAKADCKRTTPGRRVCTCKAGYTGD-GIVCLEI--NPCLENHGGCDKN 1527

  Fly   573 ------APEK--CSCNDGYEMDGENRCSPVC---------SGGCKN-GFCVAPGK----CSCDEG 615
                  .|.:  |:|...|..||:     ||         :|||.. ..|...|:    |:|...
Human  1528 AECTQTGPNQAACNCLPAYTGDGK-----VCTLINVCLTKNGGCSEFAICNHTGQVERTCTCKPN 1587

  Fly   616 YSKETGNSCK--------------------------------------PICSK------------ 630
            |..: |.:|:                                      |:.:.
Human  1588 YIGD-GFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEARVKDWDK 1651

  Fly   631 -------------GCE----------------------------------------------NGF 636
                         .|.                                              ||.
Human  1652 YGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGI 1716

  Fly   637 CDAPEK------------------------CSCNDGY---------------------------- 649
            ....:|                        .:.|:||
Human  1717 VHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFW 1781

  Fly   650 ------------------EMDSENR---------------------------------CSPVCSG 663
                              ..|::::                                 .|..|..
Human  1782 PTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGA 1846

  Fly   664 G------------CK-------------------------NGFC------IAPGKC-------SC 678
            |            |:                         .|.|      .|.|:|       ||
Human  1847 GRDIGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSC 1911

  Fly   679 DEGYSKETGNSCKPICS-------KGCENGFCDAPEKCS-------CNDGYEMDSENRCSPVCSG 729
            .. :||..|...|.:.:       :||.       |:||       |..||    ..|....|.|
Human  1912 PR-WSKPKGVKQKCLYNLPFKRNLEGCR-------ERCSLVIQIPRCCKGY----FGRDCQACPG 1964

  Fly   730 G----CKN-GFCV----APGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDG 785
            |    |.| |.|:    |.|:|.|:.|::   |.:|: :|..|.....| .|  |.|:|
Human  1965 GPDAPCNNRGVCLDQYSATGECKCNTGFN---GTACE-MCWPGRFGPDC-LP--CGCSD------ 2016

  Fly   786 ENRCSPVCSGGCKNGFCIAPGKCSCDEGYSRETGNSC------KPICSKGCE-NGFCDAPEKCSC 843
                    .|.|.:|. ...|:|.|:.|:   ||.||      ..:|:..|. :..|.....|.|
Human  2017 --------HGQCDDGI-TGSGQCLCETGW---TGPSCDTQAVLPAVCTPPCSAHATCKENNTCEC 2069

  Fly   844 NDGYEMDSENRCSPV--C---SGGC-KNGFCVAPG---KCSCDEGYSKETEISCAPF--CKDGCV 897
            |..||.|... |:.|  |   :||| |...|...|   .|||.:||..:.. ||...  |.|| :
Human  2070 NLDYEGDGIT-CTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGH-SCTEIDPCADG-L 2131

  Fly   898 NGLCVSPDFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRNGTCVEGICTCSKQYKLHRNED 962
            ||.|               .|..:|::...  |.:.               |.|    |.|...|
Human  2132 NGGC---------------HEHATCKMTGP--GKHK---------------CEC----KSHYVGD 2160

  Fly   963 DNNLICLPICEPE------CL--NGLCEFPGSCV----------CWDGESPIDGY---------S 1000
            ..|      ||||      ||  ||.|.....||          .:...||:..|         :
Human  2161 GLN------CEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREA 2219

  Fly  1001 C----QSMDSLGSLTGHEKSERHL 1020
            |    .:|.:...|:..:|::.||
Human  2220 CANEAATMATYNQLSYAQKAKYHL 2243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
STAB2	NP_060034.9	EGF_3	246..275	CDD:289699
		EGF_3	326..361	CDD:289699
		Fasciclin	382..505	CDD:280607
		Fasciclin	526..654	CDD:280607
		EGF_3	837..865	CDD:289699	7/27 (26%)
		EGF_3	920..951	CDD:289699	6/34 (18%)
		EGF_3	957..993	CDD:289699	10/39 (26%)
		Fasciclin	1009..1129	CDD:280607	6/122 (5%)
		Fasciclin	1148..1265	CDD:280607	21/123 (17%)
		EGF_3	1437..1469	CDD:289699	8/32 (25%)
		EGF_3	1475..1511	CDD:289699	11/37 (30%)
		EGF_3	1517..1553	CDD:289699	12/40 (30%)
		EGF_3	1559..1595	CDD:289699	9/36 (25%)
		Fasciclin	1617..1726	CDD:280607	5/108 (5%)
		Fasciclin	1752..1882	CDD:280607	7/129 (5%)
		EGF_3	2086..2121	CDD:289699	12/35 (34%)
		EGF_3	2127..2164	CDD:289699	15/79 (19%)
		Link_domain_TSG_6_like	2198..2290	CDD:239592	9/46 (20%)
		FAS1	2356..2449	CDD:214719
		Interaction with TMSB4X. /evidence=ECO:0000269\|PubMed:18519035	2504..2514
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2512..2551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810