DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and drpr

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	1013	Identity:	264/1013 - (26%)
Similarity:	355/1013 - (35%)	Gaps:	342/1013 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 CIT-PNNCSCNKGYKL-----NPTTQVCLPTCKDNCAAVNGFCAAPNRC--ECNPGFIPKPKSKS 193
            |:| |..||.   |::     |.|..:                 |.||.  :|..|:|    :.:
  Fly    55 CVTFPPRCST---YRIKHRVVNKTKTI-----------------AKNRIVRDCCDGYI----ASA 95

  Fly   194 FECQPKCKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICENGCVNG----NCTAPDVCQCLTGY 254
            .||.|.|...|.:|.|.:|:||:|:..|     |.  |.|:..|..|    ||:..  |.||
  Fly    96 GECVPHCSEPCQHGRCISPEKCKCDHGY-----GG--PACDINCPPGWYGRNCSMQ--CDCL--- 148

  Fly   255 TKIGHNVCLAVCPEGCQNGVCVA-PNECSCNAGYTKLEGVCTPVCKDGCVNGFCASPEKCSCNDG 318
                            .|.||.. ..:|.|..|||...  |..:|.:|.....|:  |||.|.:|
  Fly   149 ----------------NNAVCEPFSGDCECAKGYTGAR--CADICPEGFFGANCS--EKCRCENG 193

  Fly   319 YEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYIKGTGNSCKPICSKGCENGFCDAPEKCSC-N 382
                          |.|.:    ..|:|.|..|:   ||..|...|..|.....|.  :.|.| |
  Fly   194 --------------GKCHH----VSGECQCAPGF---TGPLCDMRCPDGKHGAQCQ--QDCPCQN 235

  Fly   383 DGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSC 447
            ||       :|.|            ..|.|.|:.|:   ||:.|...|..|.....|.  |.|.|
  Fly   236 DG-------KCQP------------ETGACMCNPGW---TGDVCANKCPVGSYGPGCQ--ESCEC 276

  Fly   448 NDGYEMDSENRCSPVCSGGCKNGFCVAP-----GKCSCDEGYSKET----------GNSCKPICS 497
            ..|                       ||     |:|.|..||..|.          |.:|...|.
  Fly   277 YKG-----------------------APCHHITGQCECPPGYRGERCFDECQLNTYGFNCSMTCD 318

  Fly   498 KGCEN-GFCD-APEKCSCNDGYEMDGENRCSPVCSGGCKNGF-CVAPEKCSCDEGYS----KETG 555
              |.| ..|| |...|.||.|:  .|......:|... |.|. |  ...|.||..::    .|||
  Fly   319 --CANDAMCDRANGTCICNPGW--TGAKCAERICEAN-KYGLDC--NRTCECDMEHTDLCHPETG 376

  Fly   556 NSCKPICSNGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAP--GKCSCDEGYSK 618
            | |:  ||.|..:..|..|  |:    :...|.| |...|:  ||||...:|  |.|.|..|:.
  Fly   377 N-CQ--CSIGWSSAQCTRP--CT----FLRYGPN-CELTCN--CKNGAKCSPVNGTCLCAPGWR- 428

  Fly   619 ETGNSCKPICSKGCENGFC--DAPEKCSCNDGYEMDSE-NRCSPVCSGGCKNGFCIAPGKCSCDE 680
                  .|.|.:.||.|..  |...:|.|.:|.:.:.| .:|  :|:.|.||..|..|    ||.
  Fly   429 ------GPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQC--LCTAGWKNIKCDRP----CDL 481

  Fly   681 GYSKETGNSCKPICSKGCENGFCDAPE--KCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCS 743
            .:   .|..|..:|.  |.|.....|:  .|:|..|:   :..||...|..|.....|..  ||.
  Fly   482 NH---FGQDCAKVCD--CHNNAACNPQNGSCTCAAGW---TGERCERKCDTGKFGHDCAQ--KCQ 536

  Fly   744 CDEGYS---KETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCIAP 805
            ||...|   ..|...|  :|.:......||.    :|..||.  ||| |..||.  |.|.....|
  Fly   537 CDFNNSLACDATNGRC--VCKQDWGGVHCET----NCRSGYY--GEN-CDKVCR--CLNNSSCDP 590

  Fly   806 --GKCSCDEGYSRETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGG------ 862
              |.|.|..|:   ||..    |::.|..||            |.|:.:.||..:..|.
  Fly   591 DSGNCICSAGW---TGAD----CAEPCPPGF------------YGMECKERCPEILHGNKSCDHI 636

  Fly   863 -----CKNGF--------CVA----PG---KCSCDEGYSKETEISCAPFCKDGCVNGLC--VSPD 905
                 |:.|:        |.|    ||   ||:|:.|                   |.|  |:..
  Fly   637 TGEILCRTGYIGLTCEHPCPAGLYGPGCKLKCNCEHG-------------------GECNHVTGQ 682

  Fly   906 FCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRNGTCV--------EGICTCSKQYKLHRNED 962
             |:|..|:.....::||..|....|    |.:.||   ||        :|:|.|...:...|
  Fly   683 -CQCLPGWTGSNCNESCPTDTYGQG----CAQRCR---CVHHKVCRKADGMCICETGWSGTR--- 736

  Fly   963 DNNLICLPICEPE------CLNGLCEFPGS---------CVCWDGESPIDGYSCQSMDSLGSLTG 1012
                 |..:| ||      |:| .|..|.:         |||..|.:   |.:|..:  :.|...
  Fly   737 -----CDEVC-PEGFYGEHCMN-TCACPSANFQCHAAHGCVCRSGYT---GDNCDEL--IASQRI 789

  Fly  1013 HEKSERHLK-WVFITIVSMAFILAIITTMLIIYIFRKR 1049
            .::||...: .|.:|:|.|.....||..:.|.|  |:|
  Fly   790 ADQSENSSRASVALTLVLMTLFACIIFAVFIYY--RRR 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
drpr	NP_001261276.1	EMI	27..92	CDD:284877	13/56 (23%)
		EGF_CA	274..319	CDD:304395	14/69 (20%)
		DSL	<479..518	CDD:302925	11/46 (24%)
		DSL	<567..606	CDD:302925	18/50 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810