DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and Megf10

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001094127.1	Gene:	Megf10 / 291445	RGDID:	735084	Length:	1145	Species:	Rattus norvegicus

Alignment Length:	1019	Identity:	256/1019 - (25%)
Similarity:	359/1019 - (35%)	Gaps:	332/1019 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 CIPQCASGCPNGTCITPNNCSCNKGYKLNPTTQVC-----LPTCKDNCAAVNGFCAAP--NRCEC 181
            |:|.||..|.:|.||.||.|.|..|:.....:..|     .|.|...|...|.....|  ..|.|
  Rat   105 CVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQCKNRALCNPITGACHC 169

  Fly   182 NPGFIPKPKSKSFECQPKCKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPD 246
            ..|:      :.:.|:.:|:.|.....|.  .:|:                |:||....:.|..
  Rat   170 AAGY------RGWRCEDRCEQGTYGNDCH--QRCQ----------------CQNGATCDHITGE- 209

  Fly   247 VCQCLTGYTKIGHNVCLAVCPEG-----------CQN-GVC-VAPNECSCNAGYTKLEGVCTPVC 298
             |:|..|||..   .|..:||.|           ||| ||| ....||||.:|:  :..||...|
  Rat   210 -CRCSPGYTGA---FCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGW--MGTVCGQPC 268

  Fly   299 KDGCVNGFCASPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYIKGTGNSCKPI 363
            .:|.....|:  ::|.|::|              |.|.    .|.|:|.|..||   ||..|:..
  Rat   269 PEGRFGKNCS--QECQCHNG--------------GACD----AATGQCHCSPGY---TGERCQDE 310

  Fly   364 CSKGCENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKP 428
            |..|.....|  .|.|.|.:|              |.|.:    ..|.|.|:.|:|   |..|:.
  Rat   311 CPVGTYGVRC--AETCRCVNG--------------GKCYH----VSGTCLCEAGFS---GEFCEA 352

  Fly   429 -ICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSC 492
             :|.:|.....||  ::|.|:    :|:.:.|.|:            .|:|.|..|:|   |..|
  Rat   353 RLCPEGLYGIKCD--KRCPCH----LDNTHSCHPM------------SGECGCKPGWS---GLYC 396

  Fly   493 KPICSKGCENGFCDAPEKCSCNDGYEMDG-ENRCSPVCSGGCKNGFCVAPEKCSCDEGYSKETGN 556
            ...||.|.....|.  :.|||.:|.:.|. ..||:  |:.|.|...|..|    |..|   ..|.
  Rat   397 NETCSPGFYGEACQ--QICSCQNGADCDSVSGRCA--CAPGFKGTDCSTP----CPLG---RYGI 450

  Fly   557 SCKPICSNGCENGFCDAP--EKCSCNDGYE-MDGENRCSPVCSGG-----------CKNGFCVAP 607
            :|...|  ||:|....:|  ..|.|..|:. :|    ||..|..|           |.||
  Rat   451 NCSSRC--GCKNDAVCSPVDGSCICKAGWHGVD----CSISCPSGTWGFGCNLTCQCLNG----- 504

  Fly   608 GKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDG-YEMDSENRCSPVCSGGCKNGFCI 671
            |.|:..:|       :|  .|:.|.....|:.|    |.|| |.::...||....:.||..
  Rat   505 GACNTLDG-------TC--TCAPGWRGEKCEFP----CQDGTYGLNCAERCDCSHADGCHP---- 552

  Fly   672 APGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFC 736
            ..|.|.|..|:|   |..|..:|::|.....|..|  |.|.:|..      |||
  Rat   553 TTGHCRCLPGWS---GVHCDSVCAEGRWGPNCSLP--CYCKNGAS------CSP----------- 595

  Fly   737 VAPGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDGENRCSPVC------SG 795
             ..|.|.|..|:   .|.:|:.|||.|...                    :|||..|      ||
  Rat   596 -DDGICECAPGF---RGTTCQRICSPGFYG--------------------HRCSQTCPQCVHSSG 636

  Fly   796 GCKNGFCIAPGKCSCDEGYSRETGNSCKPICSKG-----------C-ENGFCDAPEK-CSCNDGY 847
            .|.:    ..|.|.|..|:   ||..|..:|..|           | .||.|:..:: |.|..|:
  Rat   637 PCHH----ITGLCDCLPGF---TGALCNEVCPSGRFGKNCAGVCTCTNNGTCNPIDRSCQCYPGW 694

  Fly   848 -EMDSENRCSPVCSG-------GCKNG-FCVA-PGKCSCDEGYSKETEISCAPFCKDGCVNGLCV 902
             ..|....|.|...|       .|.|| ||.| .|:|.|..|:   |.:.|...|..|.....|.
  Rat   695 IGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGW---TGLYCTQRCPLGFYGKDCA 756

  Fly   903 SPDFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRNGTCVEGICTCSKQYKLHRNEDDNNLI 967
            .  .|:|.:|......|..|......:|.:  |::.|..||...|
  Rat   757 L--VCQCQNGADCDHISGQCTCRTGFMGRH--CEQKCPAGTYGYG-------------------- 797

  Fly   968 CLPICEPECL-NGLCE-FPGSCVC---WDGES----------------------PIDGYSCQSMD 1005
            |..||  :|| |..|: ..|:|.|   |.|..                      |.|.|
  Rat   798 CRQIC--DCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSY------ 854

  Fly  1006 SLGSLTGHEKSERHLKWVFITIVSMAFILAIITTMLIIYIFRKR 1049
            .:|::.|          :.:.::.:.|:||    :.:||..:::
  Rat   855 QIGAIAG----------IVVLLLVVLFLLA----LFVIYRHKQK 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Megf10	NP_001094127.1	EMI	32..99	CDD:400092
		EGF_Lam	281..318	CDD:214543	16/57 (28%)
		EGF_CA	542..587	CDD:419698	15/53 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810